Results 81 to 90 of about 1,792,929 (311)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Effectiveness of sensorimotor training in different social conditions of men’s and women’s activities in mono-gender dyads

RUDN Journal of Medicine
Relevance. Investigation the features of human achievement of the results of purposeful activity in different conditions of social interactions is relevant and of high significance.
Elena P. Murtazina, Ekaterina S. Galushka, Olga I. Ermakova, Oksana M. Zotova, Maria. A. Markovtseva, Natalia Yu. Trifonova, Sergey S. Pertsov   +6 more
doaj   +1 more source

Wetting transitions in droplet drying on soft materials

Nature Communications, 2019
It has been shown previously that substrate viscoelasticity affects surface wettability. Here the authors observe a wetting transition during drying of droplets on such substrates and elucidate it with high resolution force field measurements thereby ...
Julia Gerber, Tobias Lendenmann, Hadi Eghlidi, Thomas M. Schutzius, Dimos Poulikakos   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A promising biological model of gestational diabetes mellitus with specific impairments of carbohydrate and lipid metabolism in rats

Фармакокинетика и Фармакодинамика
Relevance. Gestational diabetes mellitus (GDM) is the most common complication of pregnancy. The lack of a biological model of GDM complicates the search for a suitable pharmacotherapy and presents the challenge of developing a valid model of this ...
K. S. Kachalov, A. S. Solomina, A. V. Rodina, A. D. Durnev   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Codon-optimization in gene therapy: promises, prospects and challenges

Frontiers in Bioengineering and Biotechnology
Codon optimization has evolved to enhance protein expression efficiency by exploiting the genetic code’s redundancy, allowing for multiple codon options for a single amino acid. Initially observed in E. coli, optimal codon usage correlates with high gene
Anastasiia Iu Paremskaia, Anna A. Kogan, Anastasiia Murashkina, Daria A. Naumova, Anakha Satish, Ivan S. Abramov, Ivan S. Abramov, Sofya G. Feoktistova, Olga N. Mityaeva, Andrei A. Deviatkin, Pavel Yu Volchkov, Pavel Yu Volchkov   +11 more
doaj   +1 more source

Robots, drugs, reality and education: how the future will change how we think [PDF]

, 2009
Emerging technologies for learning report - Article exploring various future trends and their potential impact on ...
Sandford, Richard
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