Results 91 to 100 of about 7,314,464 (305)

Enhancing South Africa’s Emerging Digital Technologies’ Innovation Ecosystem

, 2023
South Africa is ranked the top innovating mainland country on the African continent in the 2022 Global Innovation Index (GII) (WIPO, 2023). It has the second highest level of funding towards research and development on the continent (currently at 62 ...
Hanlin, Rebecca, Mlilo, Wandile
core   +1 more source

Development and assessment of an organisational readiness framework for emerging technologies : an investigation of antecedents for South African organisations' readiness for server virtualisation [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 112-125).To determine, holistically, factors that contribute to organisational readiness for these emerging technologies on one part, and the factors that influence organisational preparedness
Ogunyemi, Abiodun Afolayan
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Abundant Intra-Subtype Reassortment Revealed in H13N8 Influenza Viruses

Viruses
Influenza A viruses (IAVs) pose a serious threat to global health. On the one hand, these viruses cause seasonal flu outbreaks in humans. On the other hand, they are a zoonotic infection that has the potential to cause a pandemic.
Sofia Feoktistova, Marya Sayganova, Kseniya Trutneva, Olga Glazova, Artem S. Blagodatski, Liudmila Shevkova, Anna Navoikova, Yuriy Anisimov, Eugene Albert, Olga Mityaeva, Pavel Volchkov, Andrey Deviatkin   +11 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

MoRAine - A web server for fast computational transcription factor binding motif re-annotation

Journal of Integrative Bioinformatics, 2008
Background: A precise experimental identification of transcription factor binding motifs (TFBMs), accurate to a single base pair, is time-consuming and difficult.
Baumbach Jan, Wittkop Tobias, Weile Jochen, Kohl Thomas, Rahmann Sven   +4 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source