Results 121 to 130 of about 13,811 (304)

Effect of rofecoxib on platelet aggregation and blood loss in gynaecological and breast surgery compared with diclofenac [PDF]

, 2017
Background. Non‐selective cyclooxygenase (COX) inhibitors or non‐steroidal anti‐ inflammatory drugs (NSAIDs) are frequently omitted for perioperative pain relief because of potential side‐effects.
Baumann, P. C., Bombeli, T., Haller, U., Hegi, T. R., Pasch, T., Seifert, B., Spahn, D. R., Zalunardo, M. P.   +7 more
core  

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Does perioperative intravenous dextrose reduce postoperative nausea and vomiting? A systematic review and meta-analysis

Therapeutics and Clinical Risk Management, 2018
Seung Hyun Kim,1 Do-Hyeong Kim,2 Eungjin Kim,1 Hyun Jung Kim,3,* Yong Seon Choi2,* 1Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; 2Department of Anesthesiology and Pain Medicine,
Kim SH, Kim DH, Kim EJ, HJ Kim, Choi YS
doaj  

Cultural Replication Theory and Law [PDF]

Does law itself evolve? It has been widely suggested that culturally transmitted behavioral information exhibits a Darwinian evolutionary dynamic. The argument is straightforward. Darwinian evolution has three basic elements: (i) replicative descent with
Oliver Goodenough
core   +1 more source

Safety and efficacy of endoscopic submucosal dissection for rectal neoplasia: a multicenter North American experience. [PDF]

, 2019
Background and aims  Rectal lesions traditionally represent the first lesions approached during endoscopic submucosal dissection (ESD) training in the West. We evaluated the safety and efficacy of rectal ESD in North America.
Aadam, Abdul Aziz, Aihara, Hiroyuki, Andrawes, Sherif, Benias, Petros, Chang, Kenneth, Diehl, David L, Draganov, Peter V, Hashimoto, Rintaro, Hwang, Joo Ha, Inamdar, Sumant, Khara, Harshit S, Khashab, Mouen A, Khoshknab, Milad Pourmousavi, Kim, Raymond E, Kumta, Nikhil A, Lan, Gloria, Maniere, Thibaut, Natov, Nikola S, Ngamruengphong, Saowanee, Nosler, Michael J, Othman, Mohamed O, Perbtani, Yaseen B, Ramay, Fariha, Samarasena, Jason, Sethi, Amrita, Siegel, Amanda, Tabash, Abdalaziz, Tharian, Benjamin, Tomizawa, Yutaka, Wang, Andrew Y, Yang, Dennis, Zou, Baiming   +31 more
core   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Use of antiemetics in early pregnancy 2012–2022: A cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aim Nausea and vomiting in pregnancy impact quality of life, yet many pregnant women feel dismissed by healthcare professionals, despite the safety of first‐line antiemetic treatments for both mother and fetus. Therefore, this study aims to describe the prevalence of patient‐reported antiemetic use in early pregnancy in Copenhagen, Denmark, the changes
Katrine Bak Wraae, Nanna Roed Ballegaard, Mie Lærkeholm Hede, Line Buchgreitz, Ane Lilleøre Rom, Hanne Kristine Hegaard, Nina Olsén Nathan   +6 more
wiley   +1 more source

An Analysis of the Demarcation Problem in Philosophy of Science and Its Application to Homeopathy [PDF]

, 2018
This paper presents a preliminary analysis of homeopathy from the perspective of the demarcation problem in the philosophy of science. In this context, Popper, Kuhn and Feyerabend’s solution to the problem will be given respectively and their criteria ...
Yardımcı, Alper Bilgehan
core  

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source