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Chemical and Pharmacologic Studies on Emetine and Quaternary Emetine Derivatives
Journal of the American Pharmaceutical Association (Scientific ed.), 1950Quaternary derivatives of emetine were synthesized and tested for their pharmacologic activity. These compounds showed curarelike action and marked decrease in toxicity. Structure-activity-relationships (SAR) were noted in the three quaternary derivatives.
Kazuo K. Kimura, Andrew Lasslo
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Assay of Emetine Hydrochloride Injection
Journal of Pharmaceutical Sciences, 1970Abstract Data are presented for the DAB 7 assay of emetine hydrochloride and for quantitative assay of emetine hydrochloride injection by a method previously reported for injections of aminsalts. The method involves nonaqueous titration of a chloroform, eluted sample from a magnesium oxide‐siliceous earth mixture Thermogravimetric data show that ...
Katalin Acel, Murray M. Tuckerman
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Physical stress and emetine cardiotoxicity [PDF]
Experientia, 1961 Nous rapportons ici des experiences sur le cobaye se rapportant a la toxicite de l'emetine pour le cœur, en particulier apres potentialisations par de exercices de nage.
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JAMA: The Journal of the American Medical Association, 1933
To the Editor: —In the review on amebic dysentery in the November 18 issue ofThe Journal, in discussing the treatment, the statement is made: "In the chronic cases Craig recommends continuous treatment with emetine bismuth iodide or chiniofon." It is apparent that the writer quoted from my article in Musser's "Practice of Medicine," but in that ...
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To the Editor: —In the review on amebic dysentery in the November 18 issue ofThe Journal, in discussing the treatment, the statement is made: "In the chronic cases Craig recommends continuous treatment with emetine bismuth iodide or chiniofon." It is apparent that the writer quoted from my article in Musser's "Practice of Medicine," but in that ...
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Wirkungsmechanismus des Emetins
Zeitschrift für die gesamte experimentelle Medizin, 19301. Die subcutane Einverleibung des Emetins erzeugt eine Verringerung der CO2-Spannung der Alveolarluft und eine Vermehrung der Ausscheidung des Ammoniaks im Harn, anzeigend eine Verschiebung des Saurenbasengleichgewichtes im Organismus, welche auf die Anhaufung der sauren Ionen im Blute und die Verminderung der Alkalireserve gerichtet ist.
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1975
Emetine, the active principle of ipecac, is isolated from the roots of Cephaelis ipecacuanha, a small plant indigenous to the tropical rain forests of Brazil and countries immediately to the north. The medicinal properties of ipecac in the treatment of dysentery have long been known to the natives of Brazil (Purchas, 1625). The drug was introduced into
Arthur P. Grollman, Zelda Jarkovsky
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Emetine, the active principle of ipecac, is isolated from the roots of Cephaelis ipecacuanha, a small plant indigenous to the tropical rain forests of Brazil and countries immediately to the north. The medicinal properties of ipecac in the treatment of dysentery have long been known to the natives of Brazil (Purchas, 1625). The drug was introduced into
Arthur P. Grollman, Zelda Jarkovsky
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Effects of emetine on neuromuscular transmission
European Journal of Pharmacology, 1970Abstract Chronic administration of emitine to rats in the usual human therapeutic doses produced muscular weakness and impaired neuromuscular transmission. Recovery occurred about three weeks after its withdrawal. Intravenous injection of emetine into anaesthetised rats and cats produced a neuromuscular block which was more pronounced on tetanus ...
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