Results 101 to 110 of about 3,807,656 (336)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Perfusion CT and PET with 18F–FDG and 18F–FCh in the complex diagnosis of hepatocellular carcinoma

European Journal of Hybrid Imaging, 2017
Background The purpose of the study to evaluate possibilities of CT-perfusion and PET methods with 18F–FDG and 18F–fluorocholine in the complex diagnosis of hepatocellular carcinoma.
P. E. Tulin, M. B. Dolgushin, A. A. Odzharova, A. I. Mikhaylov, B. M. Medvedeva, S. V. Shiryaev, B. I. Dolgushin   +6 more
doaj   +1 more source

On the Apparent Nulls and Extreme Variability of PSR J1107-5907

, 2014
We present an analysis of the emission behaviour of PSR J1107-5907, a source known to exhibit separate modes of emission, using observations obtained over approximately 10 yr. We find that the object exhibits two distinct modes of emission; a strong mode
Stappers, Benjamin, {Kramer}, M, {Lyne}, A G, {Stappers}, B W, {Weltevrede}, P, {Young}, N J   +5 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Results from a Second RXTE Observation of the Coma Cluster

, 2002
The RXTE satellite observed the Coma cluster for 177 ksec during November and December 2000, a second observation motivated by the intriguing results from the first 87 ksec observation in 1996.
Duane Gruber, Ensslin T. A., Kaastra J. S., Yoel Rephaeli   +3 more
core   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Methane slip and other emissions from newbuild LNG engine under real-world operation of a state-of-the art cruise ship

Atmospheric Environment: X
Liquefied natural gas (LNG) use as shipping fuel has increased in recent years. While LNG results in lower carbon dioxide (CO2) emissions as well as benefits in terms of air pollutants, the slip of unburned methane, the main component of LNG, has ...
N. Kuittinen, P. Koponen, H. Vesala, K. Lehtoranta   +3 more
doaj   +1 more source

What Powers the Compact Radio Emission in Nearby Elliptical and S0 Galaxies?

, 1998
Many nearby early-type (elliptical and S0) galaxies contain weak (milli-Jansky level) nuclear radio sources on scales a few hundred parsecs or less. The origin of the radio emission, however, has remained unclear, especially in volume-limited samples ...
Akritas M. G., de Bruyn A. G., Ekers R. D., Fanaroff B. L., Heckman T. M., Heeschen D. S., Hine R. G., Hummel E., Luis C. Ho, Rawlings S., Sadler E. M., Sadler E. M., Slee O. B.   +12 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Improving the estimation of ship emissions using the high‐spatiotemporal resolution wind fields simulated by the Weather Research and Forecast model: A case study in China [PDF]

, 2022
Xinyi Fu, Dongsheng Chen, Xiurui Guo, Jianlei Lang, Ying Zhou   +4 more
openalex   +1 more source