Results 51 to 60 of about 515,895 (317)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Unveiling consumer satisfaction and its driving factors of EVs in China using an explainable artificial intelligence approach

Humanities & Social Sciences Communications
As China’s electric vehicle (EV) industry shifts from policy-driven to market-oriented development, understanding post-purchase satisfaction and its driving factors becomes imperative.
Chaoxi Liang, Qingtao Yang, Hongyuan Sun, Xiaoming Ma   +3 more
doaj   +1 more source

Optimizing Urban Distribution Routes for Perishable Foods Considering Carbon Emission Reduction [PDF]

, 2019
The increasing demand for urban distribution increases the number of transportation vehicles which intensifies the congestion of urban traffic and leads to a lot of carbon emissions.
Soar, Jeffrey, Liu Yang, Yongqiang Shi, Lin, Diansheng, Diansheng Lin, Wang, Jiaxin, Zhiyong Zhang, Shi, Yongqiang, Jeffrey Soar, Yang, Liu, Zhang, Zhiyong, Jiaxin Wang   +11 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Enhancing phenological model accuracy in subtropical forests using data assimilation coupled with deep learning

GIScience & Remote Sensing
Accurate monitoring of forest phenology and its temporal and spatial pattern has significant scientific relevance in revealing the carbon fixation mechanism.
Hongyu Zhu, Xuejian Li, Huaqiang Du, Li Chen, Fangjie Mao, Jie Xuan, Yinyin Zhao, Zihao Huang, Kehan Mo, Yuanqing Zheng   +9 more
doaj   +1 more source

Syngas Generation from Methane Using a Chemical-Looping Concept: A Review of Oxygen Carriers

Journal of Chemistry, 2013
Conversion of methane to syngas using a chemical-looping concept is a novel method for syngas generation. This process is based on the transfer of gaseous oxygen source to fuel (e.g., methane) by means of a cycling process using solid oxides as oxygen ...
Kongzhai Li, Hua Wang, Yonggang Wei
doaj   +1 more source

NOx Emission Prediction Based on Measurement of in-Cylinder Pressure for CI Engine Running with Diesel and Biodiesel [PDF]

, 2014
NOx is one of the major toxic emissions that needs to be regulated stringently in both EU and USA emission regulations. The engine designer is keen to get an accurate, reliable and cost effective NOx measurement system.
Gu, Fengshou, Tesfa, Belachew Chekene, Ball, Andrew, Tesfa, Belachew, Mishra, Rakesh   +4 more
core  

Analysis of the Copenhagen Accord pledges and its global climatic impacts‚ a snapshot of dissonant ambitions [PDF]

, 2010
This analysis of the Copenhagen Accord evaluates emission reduction pledges by individual countries against the Accord's climate-related objectives. Probabilistic estimates of the climatic consequences for a set of resulting multi-gas scenarios over the ...
Nabel, J., Claudine Chen, Kirsten Macey, Markmann, K., Höhne, N., Malte Meinshausen, Rogelj, J., Hare, W., Katrine Krogh Andersen, Schaeffer, M., Kathleen Markmann, William Hare, Krogh Anderson, K., Meinshausen, M., Joeri Rogelj, Andersen, K., Michiel Schaeffer, Julia Nabel, Macey, K., Hoehne, N., Chen, C., Niklas Höhne   +21 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Biochar‐Based Compound Fertilizers Enhances Carbon Sequestration and Mitigates Greenhouse Gas Emissions in Moso Bamboo Forests

GCB Bioenergy
Moso bamboo (Phyllostachys edulis) forests play a significant role in carbon sequestration, but their sustainability is threatened by nutrient depletion and greenhouse gas (GHG) emissions.
Xuekun Cheng, Yufeng Zhou, Guomo Zhou, Yongjun Shi   +3 more
doaj   +1 more source