Results 71 to 80 of about 515,895 (317)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Estimating global evapotranspiration and its components based on a modified Priestley–Taylor jet propulsion laboratory model

GIScience & Remote Sensing
Estimates of evapotranspiration (ET) and its components from satellite-based ET models have large uncertainties that hinder the understanding of the global terrestrial water cycle and its feedback to climate change.
Siyi Yang, Xiaojun Xu, Daodao Pan
doaj   +1 more source

Energy analysis on the reduction of iron from vanadium-extracted waste slag: comparison of biomass and different coals

Metalurgija, 2023
In this paper, lignite, bituminous coal, anthracite, and biomass were used as reducing agents for carbon thermal reduction of vanadium-extracted waste slag.
R. Guo, H. Q. Xie, M. Zhou, Z. Y. Wang
doaj  

MULTI-GAS EMISSION REDUCTION FOR CLIMATE CHANGE POLICY: AN APPLICATION OF FUND [PDF]

The costs of greenhouse gas emission reduction are investigated with abatement of carbon dioxide, methane, and nitrous oxide using the FUND model. The central policy scenario keeps anthropogenic radiative forcing below 4.5 Wm-2. If CO2 emission reduction
Richard S.J. Tol
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Adsorption of lead (Pb2 +) ions in wastewater by steel slag modified via ultrasound-microwave combined field

Desalination and Water Treatment
In this study, steel slag was modified via an ultrasonic-microwave combined field, and its adsorption characteristics toward Pb²⁺ were systematically investigated. The results demonstrated that the phase composition of steel slag showed no obvious change
Shiwei Fang, Zhaojun Xia, Xingmei Shen, Fabin Cao, Qianrou Peng   +4 more
doaj   +1 more source

N2O reduction in soils [PDF]

, 2008
N2O is a known greenhouse gas that increased by 16% over the last 200 years. The main sources are native and agricultural soils where predominantly soil bacteria perform nitrification and denitrification with N2O as side and intermediate product ...
Vieten, Beatrix
core   +1 more source