Results 81 to 90 of about 515,895 (317)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Novel Magnetic Fe3O4/α-FeOOH Nanocomposites and Their Enhanced Mechanism for Tetracycline Hydrochloride Removal in the Visible Photo-Fenton Process

ACS Omega, 2021
Xinyi Huang, Hui Zhou, Xiaojun Yue, Songlin Ran, Jianhua Zhu   +4 more
doaj   +1 more source

Measures to reduce fine dust emission from poultry houses: reduction from broiler houses by ionization

, 2009
In this study the effect was determined of a commercially available air ionization system on the reduction of airborne dust in a broiler house.
Harn, J., van, Winkel, A., Aarnink, A.J.A., Cambra-López, M., Hannink, N.   +4 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Unveiling High‐Resolution CH4 Profiles Over Southeast China: Novel Insights From AirCore Balloon Observations

Geophysical Research Letters
Vertical profiles of methane (CH4) are essential for validating satellite observations and quantifying regional sources and sinks. This study presents the first two high‐resolution CH4 profiles (0–25 km) over southeastern China, an economically developed
Shuo Liu, Kangxuan Wei, Bingjiang Chen, Zeping Jin, Ziyi Chen, Ziyan Wu, Zihan Fan, Shaohui Li, Kunpeng Zang, Chao Zhang, Honghui Xu, Philippe DeMaeyer, Shuangxi Fang   +12 more
doaj   +1 more source

Advanced NiCr/NiSi Thin-Film Thermocouples for Precise Temperature Sensing in Lithium-Ion Battery Systems

Sensors
Efficient thermal management is critical for the performance, safety, and longevity of lithium-ion batteries, particularly in new energy vehicles. This paper presents the development and application of a NiCr/NiSi thin-film thermocouple fabricated via ...
Xiyao Liu, Yanpeng Mao
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Multi-objective optimization of farmland water level and nitrogen fertilization management for winter wheat cultivation under waterlogging conditions based on TOPSIS-Entropy

Agricultural Water Management
Aiming at the problems of reduced winter wheat yield and aggravation of nitrogen leaching pollution caused by the waterlogging in the Middle-Lower Yangtze Plain, China, a two-year field experiment with three farmland water levels (W40, W60, W80) and ...
Pingru He, Shuang’en Yu, Jihui Ding, Tao Ma, Jin’gang Li, Yan Dai, Kaiwen Chen, Suhan Peng, Guangquan Zeng, Shuaishuai Guo   +9 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source