Results 191 to 200 of about 12,583 (231)

ChemInform Abstract: OXIDATION OF EMODIN ANTHRONE AND STEREOCHEMISTRY OF EMODIN BIANTHRONE

Chemischer Informationsdienst, 1976
AbstractSynthetisches Emodin‐bianthron läßt sich in die Diastereomeren (Ia) (meso‐Form) und (Ib) (Racemat) trennen, die sich bei milder Oxidation unterschiedlich verhalten: Beide liefern ‐ bei Zutritt von Licht ‐ Hypericin (II) [im Dunkeln statt dessen jedoch Protohypericin (IV), das entsprechend bei Belichtung in (II) übergeht]; aus (Ia) entsteht ...
D. W. CAMERON, J. S. EDMONDS, W. D. RAVERTY   +2 more
openaire   +1 more source

Emodin-nicotinamide (1:2) cocrystal identified by thermal screening to improve emodin solubility

International Journal of Pharmaceutics, 2019
Emodin (EM), an anthraquinone obtained from natural products, is known for many pharmacological activities. However, further evaluation and interpretation of toxicity or pharmacological activity of emodin are limited due to its poor aqueous solubility. We aimed to identify an emodin cocrystal with improved pharmaceutical properties.
Boosung Park, Woojin Yoon, Jungmin Yun, Eunmi Ban, Hoseop Yun, Aeri Kim   +5 more
openaire   +2 more sources

Bioassay of Cathartics. I. Emodin Type

Journal of the American Pharmaceutical Association (Scientific ed.), 1952
Tests of cathartics on the usual types of laboratory animals were reviewed. The unsatisfactory results obtained with the emodin type of drugs led to the development of a satisfactory method of bioassay on rats. The DD50 was determined by administration to a significant number of animals at several dosage levels; the consistency of the expressed fecal ...
A R, LATVEN, A B, SLOANE, J C, MUNCH
openaire   +2 more sources

Seco‐anthrachinone aus Emodin

Angewandte Chemie, 1975
Emodin (1) ist eine Schlüsselverbindung für die Biosynthese biologisch aktiver Stoffwechselprodukte von Schimmelpilzen. Einige dieser Produkte entstehen durch oxidative Öffnung des mittleren Ringes im Anthrachinongerüst. Es gelang jetzt, in Anlehnung an diese biochemische Reaktion Emodin (1) im Reagensglas mit hohen Ausbeuten in Seco‐anthrachinone (2 ...
Burchard Franck, Bernd Berger‐Lohr
openaire   +1 more source

Emodin O-methyltransferase from Aspergillus terreus

Archives of Microbiology, 1992
Emodin O-methyltransferase, an enzyme catalyzing methylation of the 8-hydroxy group of emodin, was identified in the mould Aspergillus terreus IMI 16043, a (+)-geodin producing strain. The enzyme catalyzed the formation of questin from emodin and S-adenosyl-L-methionine. By chromatography on DEAE-cellulose, Phenyl Sepharose, Q-Sepharose, Hydroxyapatite,
Z G, Chen, I, Fujii, Y, Ebizuka, U, Sankawa   +3 more
openaire   +2 more sources

Photochemistry and Phototoxicity of Aloe Emodin¶

Photochemistry and Photobiology, 2002
Photochemical pathways leading to the phototoxicity of the aloe vera constituent aloe emodin were studied. The results indicate a photochemical mechanism involving singlet oxygen to be the most likely pathway responsible for the observed phototoxicity. Aloe emodin was found to efficiently generate singlet oxygen when irradiated with UV light (phidelta =
Peter, Vath, Wayne G, Wamer, Daniel E, Falvey   +2 more
openaire   +2 more sources

Emodin: Anticancer Agent

Cancer is a serious health issue that remains a significant cause of mortality around the world. Psychosocial support, surgery, radiation, and chemotherapy are common cancer treatments. However, because of the rising rate of cancer-related mortality and the adverse or toxic side effects of cancer chemotherapy and radiation therapy, new anticancer ...
Mohd Aftab Siddiqui, Mohammad Saidur Rahman, Anas Islam, Afreen Usmani, Usama Ahmad   +4 more
openaire   +1 more source

Isotonic sodium bicarbonate-triggered emodin release from borate stabilized emodin nanoparticles-loaded polymeric microgel films

International Journal of Pharmaceutics, 2014
Hydrosoluble emodin-borate (EmB) nanoparticles (NPs) were fabricated by a simple solvent exchange method to address emodin's poor water solubility. As the result, negative charges were introduced in the surface of EmB NPs. In addition, layer-by-layer assembled multilayer films containing cation-rich polymeric microgels (named PAHD) and sodium ...
Lin Wang, Xiaohan Wang, Xiaozhou Li
openaire   +2 more sources

Synthesis of emodin methyl ethers

Australian Journal of Chemistry, 1977
Procedures are summarized for the conversion of emodin (1) into all possible mono- and di-methyl ethers. The 1-methyl ether (2) is characterized for the first time. The 1- and 8-methyl ethers are differentiated by small differences in the chemical shifts of appropriate aromatic protons of their respective 6-benzoates.
DW Cameron, MJ Crossley
openaire   +1 more source

[Emodin and organ fibrosis].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2007
The aim of this article was to investigate the mechanisms of emodin in antagonizing against organ fibrosis, and to illustrate that emodin can be an effective Chinese herbal preparation for treatment of organ fibrosis.
Zhi-qiang, Gao, Cai-hua, Wang
openaire   +1 more source