Results 61 to 70 of about 17,285 (329)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
A Novel, Multifunctional, Natural-Based Emollient: An Exhaustive Characterization of Sharofeel DS
CosmeticsEmollients are multifunctional, water-insoluble ingredients used in cosmetic products. This study aims to define the chemical and physical characteristics and test the activities of a new ester-based emollient, Sharofeel DS (DS), in comparison with other
Francesco Puzzo +5 more
doaj +1 more source
Медицинский совет, 2018 Atopic dermatitis is a disease of early childhood and the first manifestation of an atopic march. Therapy of patients with atopic dermatitis does not affect the cause of the desease and has mainly a pathogenetic or symptomatic character, which proves ...
O. В. Tamrazova
doaj +1 more source
Patients’ preferences of leave-on emollients: a survey on patients with atopic dermatitis
Journal of dermatological treatment (Print), 2020 Introduction: Atopic dermatitis is a chronic disease affecting up to 20% of children. The growing concern relating to the skin barrier dysfunction resulted in development of dermo-cosmetics market.
K. Kunkiel +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Reduced skin permeation and penetration of clobetasol propionate when Dermovate cream is applied at short time intervals with emollients [PDF]
, 2023 Background: Dermovate cream containing 0.05% clobetasol propionate is a very potent topical corticosteroid (TCS) used in the treatment of severe inflammatory dermatoses. Regular emollient therapy should continue alongside clobetasol propionate treatment,
Beebeejaun, M. T. +9 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Quality of life, emollients and hydrating agents. [PDF]
, 2006 peer reviewedSo-called dry skin is a quite common and annoying condition. This skin may affect individuals that are otherwise healthy. It may be particularly severe and unpleasant in cases of ichthyosis, atopic dermatitis or psoriasis.
Xhauflaire, Emmanuelle +3 more
core +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
ATOPIC DERMATITIS: NEW ASPECTS OF TREATMENT
Вопросы современной педиатрии, 2013 Atopic dermatitis is a chronic inflammatory cutaneous disease, which demands a prolonged treatment. A modern views on the main approaches to treatment of atopic dermatitis in children and adults are analyzed in this article. The treatment is based on the
D. Sh. Macharadze
doaj +1 more source