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Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties

Cells, 2023
An intact barrier function of the skin is important in maintaining skin health. The regulation of the skin barrier depends on a multitude of molecular and immunological signaling pathways.
Paola Baker, Christina Huang, Rakan Radi, Samara B. Moll, Emmanuela Jules, Jack L. Arbiser   +5 more
doaj   +3 more sources

Feeding the Skin Barrier: The Impact of Macro‐ and Micronutrients on Skin Barrier Function [PDF]

Clinical and Translational Allergy
Background Skin is the largest organ of the human body, and acts as a fundamental barrier. Beyond its protective role, it serves as a key immune organ, mediating immune surveillance and regulation.
Klaudia Ryczaj, Burcin Beken, Cezmi Akdis   +2 more
doaj   +2 more sources

SERPINB7 maintains skin barrier by regulating protein O-GalNAc glycosylation [PDF]

Cell Death Discovery
The skin barrier is crucial for protecting against environmental challenges, preventing water loss, and regulating immune responses. This study aims to investigate the roles and mechanisms of SERPINB7 in skin barrier maintenance.
Rui Ma, Chen Peng, Wenjuan Chen, Yizhen Zhang, Yangfeng Ding, Xin Wang, Yuling Shi   +6 more
doaj   +2 more sources

Chronic kidney disease-associated pruritus: a perspective on skin barrier damage [PDF]

Renal Failure
Chronic kidney disease-associated pruritus (CKD-aP) is a common complication in patients with end-stage kidney disease (ESKD) that seriously affects quality of life.
Fanzhou Zeng, Changhao Zhu, Lingling Ding, Bo Yang, Nanmei Liu   +4 more
doaj   +2 more sources

THE SKIN BARRIER IN SENSITIVE SKIN SYNDROME [PDF]

Journal of IMAB, 2021
Background: Sensitive Skin Syndrome (SSS) is predominantly a self-defined condition without objective pathological findings. The syndrome presents with sudden and easily provoked flushes accompanied by unpleasant sensations like itching, pain or ...
Filka Georgieva
doaj   +1 more source

Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability

Journal of Lipid Research, 2022
Desulfation of cholesterol sulfate (CholS) to cholesterol (Chol) is an important event in epidermal homeostasis and necessary for stratum corneum (SC) barrier function.
Ferdinand Fandrei, Oskar Engberg, Lukáš Opálka, Pavla Jančálková, Petra Pullmannová, Miloš Steinhart, Andrej Kováčik, Kateřina Vávrová, Daniel Huster   +8 more
doaj   +1 more source

Phospholipid-Based Microemulsions for Cutaneous Imiquimod Delivery

Pharmaceuticals, 2022
Imiquimod (IMQ) is a potent immune response modifier with antiviral and antitumor properties. IMQ’s low aqueous solubility and unsatisfactory cutaneous permeability limit its formulation into effective dosage forms.
Eleni Panoutsopoulou, Jarmila Zbytovská, Kateřina Vávrová, Georgios Paraskevopoulos   +3 more
doaj   +1 more source

The effect of long-term cigarette smoking on selected skin barrier proteins and lipids

Scientific Reports, 2023
The negative impact of cigarette smoking on the skin includes accelerated aging, pigmentation disorders, and impaired wound healing, but its effect on the skin barrier is not completely understood.
Kristýna Hergesell, Anna Paraskevopoulou, Lukáš Opálka, Vladimír Velebný, Kateřina Vávrová, Iva Dolečková   +5 more
doaj   +1 more source

The intriguing molecular dynamics of Cer[EOS] in rigid skin barrier lipid layers requires improvement of the model

Journal of Lipid Research, 2023
Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer[EOS]) are essential components of the lipid skin barrier, which protects our body from excessive water loss and the penetration of unwanted substances.
Ferdinand Fandrei, Tomáš Havrišák, Lukáš Opálka, Oskar Engberg, Albert A. Smith, Petra Pullmannová, Norbert Kučerka, Veronika Ondrejčeková, Bruno Demé, Lucie Nováková, Miloš Steinhart, Kateřina Vávrová, Daniel Huster   +12 more
doaj   +1 more source

Proline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers

Scientific Reports, 2022
Overcoming the skin barrier properties efficiently, temporarily, and safely for successful transdermal drug delivery remains a challenge. We synthesized three series of potential skin permeation enhancers derived from natural amino acid derivatives ...
Monika Kopečná, Miloslav Macháček, Jaroslav Roh, Kateřina Vávrová   +3 more
doaj   +1 more source