The pH of the skin surface and its impact on the barrier function [PDF]
, 2006 The `acid mantle' of the stratum corneum seems to be important for both permeability barrier formation and cutaneous antimicrobial defense. However, the origin of the acidic pH, measurable on the skin surface, remains conjectural.
Abeck D +41 more
core +1 more source
The Epidermal Barrier Structure and Function of Re-Harvested Skin from Non-Scalp Donor Sites
Journal of Investigative Surgery, 2023 Aim The aim of this study was to explore the epidermal barrier structure and function of re-harvested skin from non-scalp donor sites. Methods Six patients with large-area deep burns who met the inclusion and exclusion criteria were subjected to split ...
Bohan Zhang +10 more
doaj +1 more source
The Importance of Hydration in Wound Healing: Reinvigorating the clinical perspective [PDF]
, 2016 Balancing skin hydration levels is important as any disruption in skin integrity will result in disturbance of the dermal water balance. The discovery that a moist wound healing environment actively supports the healing response when compared to a dry ...
Atiyeh B.S. +14 more
core +1 more source
Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy. [PDF]
, 2016 Rosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and
Detmar, Michael +6 more
core +2 more sources
Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption-ionization-mass spectrometry imaging (MALDI-MSI). [PDF]
, 2018 Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to identify lipids directly involved as potential biomarkers ...
Amen +23 more
core +2 more sources
Skin Microbiome Composition and Key Factors of its Barrier Function
Вопросы современной педиатрии, 2023 The skin is the largest organ of the human body, it creates protective barrier between the internal and external environment. Skin barrier damage may result in homeostasis imbalance, inflammation, or bacterial infection.
Nikolay N. Murashkin +7 more
doaj +1 more source
Physiological and Molecular Effects of in vivo and ex vivo Mild Skin Barrier Disruption [PDF]
, 2018 The success of topically applied treatments on skin relies on the efficacy of skin penetration. In order to increase particle or product penetration, mild skin barrier disruption methods can be used.
Blume-Peytavi, Ulrike +6 more
core +1 more source
Molecular organization and in situ assembly of the human skin barrier [PDF]
, 2016 A deficient skin barrier function is a characteristic feature of skin diseases such as eczema, psoriasis and the ichtyoses. A malformation of the lipid matrix might be a major factor in barrier deficient skin disease.
Hollander, Lianne den
core +1 more source
Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes [PDF]
, 2020 Fibroblast growth factors (FGFs) are key regulators of tissue development, homeostasis and repair, and abnormal FGF signalling is associated with various human diseases.
Ben-Yehuda Greenwald, Maya +9 more
core +2 more sources
The epidthelial sodium channel ENaC and its regulators in the epidermal permeability barrier function [PDF]
, 2010 The highly amiloride-sensitive epithelial sodium channel ENaC is well known to be involved in controlling whole body sodium homeostasis and lung liquid clearance. ENaC expression has also been detected in the skin of amphibians and mammals.
Charles, R-P. +2 more
core +1 more source