Results 11 to 20 of about 244,453 (253)

Barrier dysfunction in the skin allergy

open access: yesAllergology International, 2018
The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic ...
Gyohei Egawa, Kenji Kabashima
doaj   +3 more sources

Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review

open access: yesFrontiers in Physiology
The interplay between the microbes and the skin barrier holds pivotal significance in skin health and aging. The skin and gut, both of which are critical immune and neuroendocrine system, harbor microbes that are kept in balance.
Yu Ri Woo, Hei Sung Kim
doaj   +3 more sources

Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin

open access: yesCosmetics, 2019
Human skin is the largest organ of the body and is an effective physical barrier keeping it from environmental conditions. This barrier function of the skin is based on stratum corneum, located in the uppermost skin.
Emine Kahraman   +3 more
doaj   +3 more sources

Skin barrier in atopic dermatitis

open access: yesFrontiers in Bioscience - Landmark, 2014
The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in ...
Natalija Novak   +2 more
exaly   +3 more sources

THE SKIN BARRIER IN SENSITIVE SKIN SYNDROME [PDF]

open access: yesJournal of IMAB, 2021
Background: Sensitive Skin Syndrome (SSS) is predominantly a self-defined condition without objective pathological findings. The syndrome presents with sudden and easily provoked flushes accompanied by unpleasant sensations like itching, pain or ...
Filka Georgieva
doaj   +1 more source

Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability

open access: yesJournal of Lipid Research, 2022
Desulfation of cholesterol sulfate (CholS) to cholesterol (Chol) is an important event in epidermal homeostasis and necessary for stratum corneum (SC) barrier function.
Ferdinand Fandrei   +8 more
doaj   +1 more source

Phospholipid-Based Microemulsions for Cutaneous Imiquimod Delivery

open access: yesPharmaceuticals, 2022
Imiquimod (IMQ) is a potent immune response modifier with antiviral and antitumor properties. IMQ’s low aqueous solubility and unsatisfactory cutaneous permeability limit its formulation into effective dosage forms.
Eleni Panoutsopoulou   +3 more
doaj   +1 more source

The effect of long-term cigarette smoking on selected skin barrier proteins and lipids

open access: yesScientific Reports, 2023
The negative impact of cigarette smoking on the skin includes accelerated aging, pigmentation disorders, and impaired wound healing, but its effect on the skin barrier is not completely understood.
Kristýna Hergesell   +5 more
doaj   +1 more source

The intriguing molecular dynamics of Cer[EOS] in rigid skin barrier lipid layers requires improvement of the model

open access: yesJournal of Lipid Research, 2023
Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer[EOS]) are essential components of the lipid skin barrier, which protects our body from excessive water loss and the penetration of unwanted substances.
Ferdinand Fandrei   +12 more
doaj   +1 more source

Proline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers

open access: yesScientific Reports, 2022
Overcoming the skin barrier properties efficiently, temporarily, and safely for successful transdermal drug delivery remains a challenge. We synthesized three series of potential skin permeation enhancers derived from natural amino acid derivatives ...
Monika Kopečná   +3 more
doaj   +1 more source

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