Results 1 to 10 of about 67,708 (303)

Astrocytic ceramide as possible indicator of neuroinflammation [PDF]

Journal of Neuroinflammation, 2019
Background Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease dementia (PDD), and frontotemporal lobar dementia (FTLD) are characterized by progressive neuronal loss but differ in their underlying pathological mechanisms ...
Nienke M. de Wit, Sandra den Hoedt, Pilar Martinez-Martinez, Annemieke J. Rozemuller, Monique T. Mulder, Helga E. de Vries   +5 more
doaj   +2 more sources

Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I

Journal of Lipid Research, 2006
Ceramide is a component of the sphingomyelin cycle and a well-established lipid signaling molecule. We recently reported that ceramide specifically increased ABCA1-mediated cholesterol efflux to apolipoprotein A-I (apoA-I), a critical process that leads ...
Amy B. Ghering, W. Sean Davidson
doaj   +1 more source

Quantitative analysis of ceramide molecular species by high performance liquid chromatography

Journal of Lipid Research, 1998
A method was developed for quantitative analysis of molecular species of ceramide (N-acyl-sphingosine) and dihydroceramide (N-acyl sphinganine) by high performance liquid chromatography (HPLC).
Midori Yano, Etsu Kishida, Yuka Muneyuki, Yasuo Masuzawa   +3 more
doaj   +1 more source

LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia

Journal of Lipid Research, 2005
Ceramide is a key bioactive mediator that inhibits surfactant phosphatidylcholine (PtdCho) synthesis in lung epithelia. Ceramide availability is governed by sphingomyelin (SM) hydrolysis, but less is known regarding its de novo synthesis.
Zhiwei Xu, Jiming Zhou, Diann M. McCoy, Rama K. Mallampalli   +3 more
doaj   +1 more source

Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

iScience
Summary: Mechanisms by which Porphyromonas gingivalis (P. gingivalis) infection enhances oral tumor growth or resistance to cell death remain elusive. Here, we determined that P.
Megan Sheridan, Nityananda Chowdhury, Bridgette Wellslager, Natalia Oleinik, Mohamed Faisal Kassir, Han G. Lee, Mindy Engevik, Yuri Peterson, Subramanya Pandruvada, Zdzislaw M. Szulc, Özlem Yilmaz, Besim Ogretmen   +11 more
doaj   +1 more source

Coupling In vitro and In vivo Paradigm Reveals a Dose Dependent Inhibition of Angiogenesis Followed by Initiation of Autophagy by C6-Ceramide

International Journal of Biological Sciences, 2011
The activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also determined.
Rishipal R. Bansode, Mohamed Ahmedna, Kurt R. Svoboda, Jack N. Losso
doaj  

Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances

Metabolites
Background/Objectives: Ceramide, a sphingolipid metabolite, has emerged as a key player in various physiological and pathological processes. Changes in ceramide levels are associated with the occurrence and development of various diseases, highlighting ...
Xueping Shen, Rui Feng, Rui Zhou, Zhaoyang Zhang, Kaiyong Liu, Sheng Wang   +5 more
doaj   +1 more source

Ceramide Initiates NFκB-Mediated Caspase Activation in Neuronal Apoptosis

Neurobiology of Disease, 2000
The objective of the present study was to evaluate the role of ceramide in mediating apoptosis of dorsal root ganglion neurons induced by either nerve growth factor withdrawal or treatment with the chemotherapeutic agents suramin and cisplatin ...
Jagjit S. Gill, Anthony J. Windebank
doaj   +1 more source

Unravelling neuronal and glial differences in ceramide composition, synthesis, and sensitivity to toxicity

Communications Biology
Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several neurologic diseases.
John J. McInnis, Disha Sood, Lilu Guo, Michael R. Dufault, Mariana Garcia, Rachel Passaro, Grace Gao, Bailin Zhang, James C. Dodge   +8 more
doaj   +1 more source

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence. [PDF]

J Cachexia Sarcopenia Muscle
Park SJ, Baek JY, Wei S, Lee JY, Lee Y, Lee SH, Jang IY, Sakong H, Yoo HJ, Jung HW, Lee E, Kim SJ, Jo Y, Kim K, Ryu D, Kim BJ.   +15 more
europepmc   +1 more source