Results 1 to 10 of about 100,682 (159)
The structural requirements for ceramide activation of serine-threonine protein phosphatases
Journal of Lipid Research, 2004 The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E Chalfant, Yusuf Awni Hannun
exaly +3 more sources
Journal of Lipid Research, 2008 Increased mitochondrial ceramide levels are associated with the initiation of apoptosis. There is evidence that ceramide is causal. Thus, the conversion of the precursor, dihydroceramide, to ceramide by the enzyme dihydroceramide desaturase may be ...
Johnny Stiban, Marco Colombini
exaly +3 more sources
Development and characterization of a novel anti-ceramide antibody
Journal of Lipid Research, 2007 Ceramide is emerging as a key sphingolipid that regulates a variety of cellular processes. To facilitate the study of ceramide localization and its interaction with cellular proteins, we have developed a novel antibody against ceramide.
Somsankar Dasgupta, Erhard Bieberich
exaly +3 more sources
Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. [PDF]
PLoS ONE, 2016 Here, we studied the underlying mechanism of aldosterone (Aldo)-induced vascular endothelial cell damages by focusing on ceramide. We confirmed that Aldo (at nmol/L) inhibited human umbilical vein endothelial cells (HUVEC) survival, and induced ...
Yumei Zhang +7 more
doaj +1 more source
Cells, 2022 Since ceramide is a key epidermal barrier constituent and its deficiency causes barrier-compromised skin, several molecular types of ceramides are formulated in commercial topical agents to improve barrier function. Topical ceramide localizes on the skin
Kyong-Oh Shin +4 more
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Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif
PLoS ONE, 2022 The important membrane lipid, ceramide, is generated by a family of homologous enzymes, the ceramide synthases (CerSs), multi-spanning membrane proteins located in the endoplasmic reticulum.
Jiyoon Kim +4 more
doaj +2 more sources
The targeting of plasmalemmal ceramide to mitochondria during apoptosis. [PDF]
PLoS ONE, 2011 Ceramide is a key lipid mediator of cellular processes such as differentiation, proliferation, growth arrest and apoptosis. During apoptosis, ceramide is produced within the plasma membrane.
Eduard B Babiychuk +6 more
doaj +1 more source
Fermentation, 2019 Koji, which is used for manufacturing Japanese traditional fermented foods, has long been safely used as a cosmetic product. Although its cosmetic effect has been empirically established, the underlying mechanism has not been reported.
Miyuki Miyagawa +6 more
doaj +1 more source
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]
, 2015 Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C +9 more
core +2 more sources
Brain ceramide hexosides in Tay-Sachs disease and generalized gangliosidosis (GM1-gangliosidosis)
Journal of Lipid Research, 1967 The carbohydrate composition was determined for ceramide hexosides isolated from brains of patients with Tay-Sachs disease and generalized gangliosidosis (hereby named GM1-gangliosidosis).Gray matter of patients with each disease showed a characteristic ...
Kunihiko Suzuki, Gloria C. Chen
doaj +1 more source