Results 41 to 50 of about 100,829 (298)

Detergent-Resistant, Ceramide-Enriched Domains in Sphingomyelin/Ceramide Bilayers [PDF]

Biophysical Journal, 2006
When cell membranes are treated with Triton X-100 or other detergents at 4 degrees C, a nonsolubilized fraction can often be recovered, the "detergent-resistant membranes", that is not found when detergent treatment takes place at 37 degrees C. Detergent-resistant membranes may be related in some cases to membrane "rafts".
Sot, Jesus, Bagatolli, Luis, Goñi, Felix Maria, Alonso, Alicia   +3 more
openaire   +5 more sources

Synthesis and biological evaluation of novel PDMP analogues [PDF]

, 2006
A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward ...
Boldin-Adamsky, Swetlana, Busson, Roger, Futerman, Anthony H, Hillaert, Ulrik, Rozenski, Jef, Van Calenbergh, Serge   +5 more
core   +1 more source

Developmental Comparison of Ceramide in Wild-Type and Cln3Δex7/8 Mouse Brains and Sera

Frontiers in Neurology, 2019
CLN3 disease is a neurodevelopmental disease leading to early visual failure, motor decline, and death. CLN3 pathogenesis has been linked to dysregulation of ceramide, a key intracellular messenger impacting various biological functions.
Sally El-Sitt, Jihane Soueid, Jamal Al Ali, Joelle Makoukji, Nadine J. Makhoul, Hayat Harati, Rose-Mary Boustany   +6 more
doaj   +1 more source

Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells. [PDF]

, 2019
FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans. Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer ...
Chang, Nai-Chuan, Chen, I-Ju, Ho, Ching-Liang, Lai, Tai-Yu, Lee, Andy Chi-Lung, Liao, Guo-Shiou, Lin, Ruey-Jen, Wu, Jen-Chine, Yeo, Hui-Ling, Yu, Alice L   +9 more
core   +2 more sources

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Separation of neutral glycosphingolipids and sulfatides by thin-layer chromatography

Journal of Lipid Research, 1967
Two one-dimensional systems for separation of glycolipids from total lipid extracts of tissues by thin-layer chromatography are described. System I used, as adsorbent, an alkaline mixture of silica gel without CaSO4 binder (75%) and magnesium silicate ...
Vladimir P. Skipski, Anson F. Smolowe, Marion Barclay   +2 more
doaj   +1 more source

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

Cell Reports, 2021
Summary: We lack a mechanistic understanding of aging-mediated changes in mitochondrial bioenergetics and lipid metabolism that affect T cell function.
Silvia Vaena, Paramita Chakraborty, Han Gyul Lee, Alhaji H. Janneh, Mohamed Faisal Kassir, Gyda Beeson, Zachariah Hedley, Ahmet Yalcinkaya, M. Hanief Sofi, Hong Li, Monica L. Husby, Robert V. Stahelin, Xue-Zhong Yu, Shikhar Mehrotra, Besim Ogretmen   +14 more
doaj   +1 more source

Porcine intestinal glycosphingolipids recognized by F6-fimbriated enterotoxigenic Escherichia coli [PDF]

, 2014
One important virulence factor of enterotoxigenic Escherichia coli is their ability to adhere via fimbrial adhesins to specific receptors located on the intestinal mucosa. Here, the potential glycosphingolipid receptors of enterotoxigenic F6-fimbriated E.
Benktander, John, Coddens, Annelies, Cox, Eric, Johansson, Miralda Madar, Teneberg, Susann   +4 more
core   +2 more sources

Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis [PDF]

Journal of Lipid Research, 2007
Ceramide kinase (CERK) is a critical mediator of eicosanoid synthesis, and its product, ceramide-1-phosphate (C1P), is required for the production of prostaglandins in response to several inflammatory agonists. In this study, mass spectrometry analysis disclosed that the main forms of C1P in cells were C(16:0) C1P and C(18:0) C1P, suggesting that CERK ...
Nadia F. Lamour, Robert V. Stahelin, Dayanjan S. Wijesinghe, Michael Maceyka, Elaine Wang, Jeremy C. Allegood, Alfred H. Merrill, Jr., Wonhwa Cho, Charles E. Chalfant   +8 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source