Results 41 to 50 of about 67,708 (303)

Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia [PDF]

, 2023
Acute myelogenous leukemia (AML), the most prevalent acute and aggressive leukemia diagnosed in adults, often recurs as a difficult-to-treat, chemotherapy-resistant disease.
Johnson Ung, Gemma Fabrias, Fisher-Wellman, Kelsey H., Todd E. Fox, Debajit Bhowmick, Cabot, Myles C., Chalfant, Charles E., Golla, Upendarrao, Kelsey H. Fisher-Wellman, Sharma, Arati, Upendarrao Golla, Shaw, Jeremy J. P., Fox, Todd E., Jose’ Luis Abad, David F. Claxton, Neufer, P Darrell, Ung, Johnson, Arati Sharma, Bhowmick, Debajit, James T. Hagen, Tan, Su-Fern, Mark Kester, Myles C. Cabot, Kassai, Miki, Miki Kassai, Su-Fern Tan, Jeremy J. P. Shaw, Feith, David J., Fabriàs, Gemma, Loughran, Thomas P., Fox, Todd E, Claxton, David F., P. Darrell Neufer, Kester, Mark, Hagen, James T., David J. Feith, Abad, José Luis, Thomas P. Loughran, Charles E. Chalfant   +38 more
core   +1 more source

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody

Frontiers in Cell and Developmental Biology, 2019
Ceramide-rich platforms (CRPs) mediate association of proteins with the sphingolipid ceramide and may regulate protein interaction in membrane contact sites to the cytoskeleton, organelles, and infectious pathogens.
Xue Jiang, Xue Jiang, Zhihui Zhu, Haiyan Qin, Priyanka Tripathi, Liansheng Zhong, Liansheng Zhong, Ahmed Elsherbini, Sanjib Karki, Simone M. Crivelli, Wenbo Zhi, Guanghu Wang, Stefanka D. Spassieva, Erhard Bieberich   +13 more
doaj   +1 more source

Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy

European Journal of Cell Biology, 2023
Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their ...
Javad Alizadeh, Simone C. da Silva Rosa, Xiaohui Weng, Joadi Jacobs, Shahrokh Lorzadeh, Amir Ravandi, Rui Vitorino, Stevan Pecic, Aleksandra Zivkovic, Holger Stark, Shahla Shojaei, Saeid Ghavami   +11 more
openaire   +3 more sources

Ceramide is More Effective than Shea Butter in Maintaining Skin Acidity

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2022
Background: Skin is the largest organ that functions as a physical barrier. Stable skin pH can maximize its function. Ceramide and shea butter cream have components that maintain the skin pH in the stratum corneum. Purpose: The aim is to compare ceramide
Zilpa Widyastuti, Suci Widhiati
doaj   +1 more source

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

, 2005
Current understanding of IGF-I-mediated neuroprotection implies the activation of phosphatidylinositol-3-kinase (PI-3K), which leads to the activation of Akt/Protein Kinase B.
Brugg, B., Arbez, N., Willaime-Morawek, S., Mariani, J.   +3 more
core   +1 more source

Synthesis of Cyclopropene‐Modified Fatty Acids Allows Single‐Cell Quantification of Uptake by Immune Cells

Angewandte Chemie, EarlyView.
Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda, Graham A. Heieis, Laura Bogue Edgerton, Kristine Bertheussen, Diana Torres‐García, Marouane el Boujadayni, Kas Steuten, Jeroen M. Punt, Wouter P. F. Driever, Connor Corrigan, Xinyuan Wang, Bart Everts, David Finlay, Mario van der Stelt, Sander I. van Kasteren   +14 more
wiley   +2 more sources

A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane

Journal of Lipid Research, 2023
The role of ceramide in biological functions is typically based on the elevation of cellular ceramide, measured by LC-MS in the total cell lysate. However, it has become increasingly appreciated that ceramide in different subcellular organelles regulates
Meaghan Greene, Maria Jose Hernandez-Corbacho, Anne G. Ostermeyer-Fay, Yusuf A. Hannun, Daniel Canals   +4 more
doaj   +1 more source

Lipids of the spleen in Gaucher's disease

Journal of Lipid Research, 1965
Thin-layer chromatography (TLC) was used to analyze lipids of eight spleens of patients with Gaucher's disease. Four non-Gaucher spleens were also analyzed.
William D. Suomi, Bernard W. Agranoff
doaj   +1 more source

Ceramide Metabolism as a Potential Target for Treatment of Parkinson’s Disease

, 2023
This thesis explores the role of ceramide metabolism in Parkinson’s disease (PD), highlighting its potential as a therapeutic target. Ceramides, crucial for various cellular processes and cell signaling, may contribute to PD progression when their ...
Maigari, Maryam Bello
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source