Results 41 to 50 of about 72,817 (297)

Characterization of neutral sphingolipids from chicken erythrocytes.

Journal of Lipid Research, 1985
The neutral sphingolipids from chicken erythrocytes were characterized. The total concentration of neutral sphingolipids was found to be 480 nmol/g of dry stroma.
T Shiraishi, Y Uda
doaj   +1 more source

A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane

Journal of Lipid Research, 2023
The role of ceramide in biological functions is typically based on the elevation of cellular ceramide, measured by LC-MS in the total cell lysate. However, it has become increasingly appreciated that ceramide in different subcellular organelles regulates
Meaghan Greene, Maria Jose Hernandez-Corbacho, Anne G. Ostermeyer-Fay, Yusuf A. Hannun, Daniel Canals   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

Cell Reports, 2021
Summary: We lack a mechanistic understanding of aging-mediated changes in mitochondrial bioenergetics and lipid metabolism that affect T cell function.
Silvia Vaena, Paramita Chakraborty, Han Gyul Lee, Alhaji H. Janneh, Mohamed Faisal Kassir, Gyda Beeson, Zachariah Hedley, Ahmet Yalcinkaya, M. Hanief Sofi, Hong Li, Monica L. Husby, Robert V. Stahelin, Xue-Zhong Yu, Shikhar Mehrotra, Besim Ogretmen   +14 more
doaj   +1 more source

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations [PDF]

, 2009
Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences.
S. Campbell, Aulchenko, Y.S. (Yurii), Igl, Wilmar,, Zaboli, Ghazal, Polasek, O. (Ozren), A. Wright, J. F. Wilson, Gyllensten, U, Hicks, Andrew A, Schwienbacher, C, Hengstenberg, Christian, I. R. König, Peter Ugocsai, A. Demirkan, C. Pattaro, Wichmann, H.-E., G. Liebisch, Peters, Annette, Kirichenko, Anatoly V, Liebisch, G, Peters, A. (Annette), Witteman, Jacqueline C. M., Wright, Alan, C. Hengstenberg, O. Polasek, König, Inke R, P. Ugocsai, Janssens, A. Cecilej W., Hayward, C., Campbell, Harry, Campbell, H, Pichler, I. (Irene), Pichler, I., Gerhard Liebisch, Demirkan, A., Campbell, S, Biloglav, Z. (Zrinka), P. P. Pramstaller, Kolcic, I, Johansson, Asa, Liebisch, Gerhard, C. M. van, Wichmann, H.E. (Heinz Erich), Janssens, A Cecilej W, Meitinger, T., Wild, SH, Ozren Polasek, Igl, W., Jeanette Erdmann, Schmitz, G, Franklin, CS, S. Schreiber, Jonasson, I, Wichmann, H-Erich, Ugocsai, P, Polsek, Ozren, Wichmann, H.-Erich, Cornelia M van Duijn, Hengstenberg, C, Erdmann, J. (Jeanette), H. Campbell, König, I.R. (Inke), Axenovich,T.I., G. Schmitz, Y. Aulchenko, S. H. Wild, Schreiber, Stefan, Gyllensten, Ulf,, Campbell, Harry; id_orcid, I. Rudan, G. Zaboli, Schreiber, S., Ivana Kolcic, Johansson, A, Wright, A, Franklin, Christopher S, Kolcic, I., Zorkoltseva, I.V. (Irina), Wilson, J.F., Rudan, I. (Igor), Johansson, A. (Åsa), Zorkoltseva, I.V., Schwienbacher, Christine, Duijn, Cornelia, Marroni, Fabio, Witteman, Jacqueline C M, Fabio Marroni, Zaboli, Ghazal,, Jonasson, Inger, Hicks, A.A. (Andrew), Irene Pichler, Gyllensten, U., Campbell, H., Wichmann, HE, A Cecilej W Janssens, Pramstaller, P.P. (Peter Paul), Janssens, A.C., Peters, A., Wild, S.H., Isaacs, A., Pichler, Irene, Vitart, Veronique, N. Hastie, Tatiana I Axenovich, Johansson, Åsa,, I. Kolcic, Ghazal Zaboli, James F Wilson, Kolcic, I. (Ivana), Wilson, James F; id_orcid, Biloglav, Zrinka, Ugocsai, P. (Peter), Gnewuch, C., A. Johansson, Zaboli, G., Marroni, F, Andrew A Hicks, Pattaro, C., Pichler, I, Christian Hengstenberg, Jacqueline C M Witteman, Schunkert, H, Biloglav, Z, Caroline Hayward, Pattaro, Cristian, C. Hayward, Koenig, Inke R., Zrinka Biloglav, Demirkan, A. (Ayşe), Liebisch, G., J. Erdmann, Franklin, C.S. (Christopher), I. V. Zorkoltseva, U. Gyllensten, Alan Wright, Pattaro, C, Franklin, Christopher S., Hengstenberg, C. (Christian), A. V. Kirichenko, Harry Campbell, Schunkert, H., W. Igl, Hastie, N., Ulf Gyllensten, C. Schwienbacher, Kirichenko, AV, Demirkan, Ayse, Janssens, A. CecileJ.W., Schreiber, S, Wild, S.H. (Sarah), Zorkoltseva, IV, Schwienbacher, C. (Christine), Erdmann, Jeanette, Yurii Aulchenko, Asa Johansson, Ben A Oostra, Aulchenko, Y., Veronique Vitart, Liebisch, G. (Gerhard), B. A. Oostra, Janssens, Cecile, Christine Schwienbacher, Hastie, N, A. C. W, Rudan, Igor, Igl, W. (Wilmar), I. Pichler, Erdmann, J., C. Gnewuch, Konig, IR, Anatoly V Kirichenko, Schwienbacher, C., van Duijn, C.M., Jonasson, I., Kirichenko, A.V. (Anatoly), Schmitz, G., Hicks, Andrew A., A. A. Hicks, Susan Campbell, Annette Peters, Gerd Schmitz, Hayward, Caroline, Zorkoltseva, Irina V, Witteman, JCM, T. I. Axenovich, Gnewuch, C, König, I.R., Carsten Gnewuch, H. Wichmann, Gyllensten, Ulf, Igl, Wilmar, Meitinger, T, Kirichenko, Anatoly V., H-Erich Wichmann, Cristian Pattaro, C. S. Franklin, Gnewuch, Carsten, König, Inke R., Isaacs, A.J. (Aaron), Erdmann, J, Zaboli, G. (Ghazal), Christopher S Franklin, Campbell, S., Irina V Zorkoltseva, Zorkoltseva, Irina V., Hengstenberg, C., Zaboli, G, Hicks, A.A., Peter P Pramstaller, Marroni, F. (Fabio), Sarah H Wild, Ayse Demirkan, Johansson, A., Wright, A., Hicks, AA, Wichmann, Heinz-Erich, Nick Hastie, Hastie, Nick, H. Schunkert, Polasek, Ozren, Janssens, A. Cecile J. W., Inger Jonasson, Axenovich, TI, Polasek, O., Peters, A, Oostra, Ben A., Oostra, B.A., Wright, A.F. (Alan), Axenovich, T.I. (Tatiana), van Duijn, Cornelia M., Heribert Schunkert, Vitart, V. (Veronique), Hastie, N. (Nick), Wild, Sarah H; id_orcid, Schmitz, Gerd, Hayward, C. (Caroline), Biloglav, Z., Schunkert, H. (Heribert), Campbell, S. (Susan), A. Peters, Ugocsai, Peter, T. Meitinger, Oostra, Ben, Inke R König, Kolcic, Ivana, Stefan Schreiber, Gibson, Greg, Schunkert, Heribert, Z. Biloglav, Rudan, I., Isaacs, Aaron, V. Vitart, Tikka-Kleemola, P. (Päivi), Wilson, JF, Oostra, B.A. (Ben), Franklin, C.S., Jonasson, I. (Inger), Wilson, James F., Schreiber, S. (Stefan), Pramstaller, Peter P, Rudan, I, Wild, Sarah H., Schmitz, G. (Gerd), Janssens, A.C.J.W. (Cécile), Oostra, Ben A, Vitart, V, Meitinger, Thomas, Vitart, V., Aulchenko, Yurii, Pramstaller, PP, Gnewuch, C. (Carsten), Marroni, F., Campbell, Susan, Axenovich, Tatiana I., Hayward, C, Witteman, J.C.M. (Jacqueline), J. C. M, Wilmar Igl, Igl, W, Axenovich, Tatiana I, Kirichenko, A.V., Aulchenko, Yuriy, Wilson, J.F. (James), Gyllensten, U. (Ulf), van Duijn, Cornelia M, Meitinger, T. (Thomas), Hayward, Caroline; id_orcid, Thomas Meitinger, Ugocsai, P., Pattaro, C. (Cristian), Polasek, O, I. Jonasson, Pramstaller, Peter P., Aaron Isaacs, Igor Rudan, Witteman, J.C., Jonasson, Inger,, A. Isaacs, Pramstaller, P.P., Wild S. H., Schmitz G., Hastie Nick, Schreiber S., Campbell Susan, Peters Annette, Erdmann Jeanette, Wright A., Oostra B. A., Vitart Veronique, Zorkoltseva I. V, Witteman J. C., Johansson A, Zaboli Ghazal, Schreiber Stefan, Ugocsai P, König I. R., Pichler I., Liebisch Gerhard, Aulchenko Y, Hastie N., Pattaro C, Wild Sarah H., Zaboli G., Aulchenko Yurii, Isaacs A., Wichmann H. E., Hicks, AA;Pramstaller, PP;Johansson, Å;Vitart, V;Rudan, I;Ugocsai, P;Aulchenko, Y;Franklin, CS;Liebisch, G;Erdmann, J;Jonasson, I;Zorkoltseva, IV;Pattaro, C;Hayward, C;Isaacs, A;Hengstenberg, C;Campbell, S;Gnewuch, C;Janssens, AC;Kirichenko, AV;König, IR;Marroni, F;Polasek, O;Demirkan, A;Kolcic, I;Schwienbacher, C;Igl, W;Biloglav, Z;Witteman, JC;Pichler, I;Zaboli, G;Axenovich, TI;Peters, A;Schreiber, S;Wichmann, HE;Schunkert, H;Hastie, N;Oostra, BA;Wild, SH;Meitinger, T;Gyllensten, U;van Duijn, CM;Wilson, JF;Wright, A;Schmitz, G;Campbell, H, Schmitz Gerd, Kolcic Ivana, Campbell S., Schunkert H., Gyllensten U., Franklin Christopher S., Demirkan A., Liebisch G, Axenovich T. I., Rudan Igor, Witteman Jacqueline C. M., Wichmann H.-Erich, Hengstenberg Christian, Pramstaller PP, van Duijn Cornelia M., Oostra Ben A., Rudan I, Vitart V, Kolcic I., Ugocsai Peter, Gnewuch C., Franklin CS, Gyllensten Ulf, Biloglav Zrinka, Wilson James F., Igl Wilmar, Marroni F., Schunkert Heribert, van Duijn C. M., Zorkoltseva Irina V., Meitinger T., Meitinger Thomas, Kirichenko Anatoly V., Pichler Irene, Janssens A. C., Campbell H., Jonasson Inger, Biloglav Z., Peters A., Johansson Åsa, Hicks Andrew A., Demirkan Ayse, Isaacs Aaron, Hayward C., Hayward Caroline, Jonasson I, Kirichenko A. V., Erdmann J, Igl W., Schwienbacher Christine, Axenovich Tatiana I., Marroni Fabio, Polasek O., Pramstaller Peter P., Janssens A. CecileJ.W., Hicks AA, Pattaro Cristian, Polasek Ozren, Wilson J. F., Wright Alan, Gnewuch Carsten, Campbell Harry, Hengstenberg C., König Inke R.   +390 more
core   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis [PDF]

Journal of Lipid Research, 2007
Ceramide kinase (CERK) is a critical mediator of eicosanoid synthesis, and its product, ceramide-1-phosphate (C1P), is required for the production of prostaglandins in response to several inflammatory agonists. In this study, mass spectrometry analysis disclosed that the main forms of C1P in cells were C(16:0) C1P and C(18:0) C1P, suggesting that CERK ...
Nadia F. Lamour, Robert V. Stahelin, Dayanjan S. Wijesinghe, Michael Maceyka, Elaine Wang, Jeremy C. Allegood, Alfred H. Merrill, Jr., Wonhwa Cho, Charles E. Chalfant   +8 more
openaire   +3 more sources

Modeling SMS driven conversion of ceramide to sphingomyelin reveals the existence of a positive feedback mechanism [PDF]

, 2012
In questa tesi presentiamo un modello matematico minimo per la conversione di un ceramide in sfingomielina catalizzata dall'enzima sfingomielina sintasi 1 (SMS1) basato sulle leggi della cinetica chimica.
Thomaseth, Caterina
core  

Ceramide Metabolism as a Potential Target for Treatment of Parkinson’s Disease

, 2023
This thesis explores the role of ceramide metabolism in Parkinson’s disease (PD), highlighting its potential as a therapeutic target. Ceramides, crucial for various cellular processes and cell signaling, may contribute to PD progression when their ...
Maigari, Maryam Bello
core  

Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia [PDF]

, 2023
Acute myelogenous leukemia (AML), the most prevalent acute and aggressive leukemia diagnosed in adults, often recurs as a difficult-to-treat, chemotherapy-resistant disease.
Johnson Ung, Gemma Fabrias, Fisher-Wellman, Kelsey H., Todd E. Fox, Debajit Bhowmick, Cabot, Myles C., Chalfant, Charles E., Golla, Upendarrao, Kelsey H. Fisher-Wellman, Sharma, Arati, Upendarrao Golla, Shaw, Jeremy J. P., Fox, Todd E., Jose’ Luis Abad, David F. Claxton, Neufer, P Darrell, Ung, Johnson, Arati Sharma, Bhowmick, Debajit, James T. Hagen, Tan, Su-Fern, Mark Kester, Myles C. Cabot, Kassai, Miki, Miki Kassai, Su-Fern Tan, Jeremy J. P. Shaw, Feith, David J., Fabriàs, Gemma, Loughran, Thomas P., Fox, Todd E, Claxton, David F., P. Darrell Neufer, Kester, Mark, Hagen, James T., David J. Feith, Abad, José Luis, Thomas P. Loughran, Charles E. Chalfant   +38 more
core   +1 more source