Results 61 to 70 of about 67,929 (292)
Regulation of neutral ceramidase in glomerular messangial cells [PDF]
, 2009 During the past several years, ceramide has emerged as an important second messenger triggering cell responses including proliferation, differentiation, growth arrest and apoptosis.
Franzen, Rochus
core
Identification and characterization of protein phosphatase 2C activation by ceramide[S]
Journal of Lipid Research, 2012 Ceramide is a bioactive sphingolipid with many associated biological outcomes, yet there is a significant gap in our current understanding of how ceramide mediates these processes.
David M. Perry +4 more
doaj +1 more source
Inimitable Impacts of Ceramides on Lipid Rafts Formed in Artificial and Natural Cell Membranes
Membranes, 2022 Ceramide is the simplest precursor of sphingolipids and is involved in a variety of biological functions ranging from apoptosis to the immune responses. Although ceramide is a minor constituent of plasma membranes, it drastically increases upon cellular ...
Masanao Kinoshita, Nobuaki Matsumori
doaj +1 more source
Advanced Materials, EarlyView.Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi +3 more
wiley +1 more source
Presentation_1_Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody.pptx [PDF]
, 2019 Ceramide-rich platforms (CRPs) mediate association of proteins with the sphingolipid ceramide and may regulate protein interaction in membrane contact sites to the cytoskeleton, organelles, and infectious pathogens.
Xue Jiang (411020) +11 more
core +1 more source
Advanced Science, EarlyView.This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu +5 more
wiley +1 more source
Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization Mechanism [PDF]
, 2017 Ceramide is a sphingolipid involved in several cellular processes, including apoptosis. It has been proposed that ceramide forms large and stable channels in the mitochondrial outer membrane that induce cell death through direct release of cytochrome c ...
David Gil +13 more
core +1 more source
Ceramide in cerebrovascular diseases [PDF]
, 2023 Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway.
Huiqi Yuan +3 more
core +1 more source
Advanced Science, EarlyView.Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang +6 more
wiley +1 more source
Roles and therapeutic targeting of ceramide metabolism in cancer
Molecular MetabolismBackground: Ceramides are sphingolipids that act as signaling molecules involved in regulating cellular processes including apoptosis, proliferation, and metabolism.
Narendra Wajapeyee +2 more
doaj +1 more source