Results 81 to 90 of about 67,708 (303)
Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. [PDF]
PLoS ONE, 2011 BACKGROUND:Evidence indicates that Bax functions as a "lipidic" pore to regulate mitochondrial outer membrane permeabilization (MOMP), the apoptosis commitment step, through unknown membrane elements.
Hyunmi Lee +14 more
doaj +1 more source
Marine silicon for biomedical sustainability
BMEMat, EarlyView.Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han +3 more
wiley +1 more source
Fluorescent annexin A1 reveals dynamics of ceramide platforms in living cells
, 2008 Upon its genesis during apoptosis, ceramide promotes gross reorganization of the plasma membrane structure involving clustering of signalling molecules and an amplification of vesicle formation, fusion and trafficking.
Katia Monastyrskaya +5 more
core +1 more source
BMEMat, EarlyView.A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie +12 more
wiley +1 more source
Glucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cells. [PDF]
PLoS ONE, 2014 Accumulating evidence suggests that glucolipotoxicity, arising from the combined actions of elevated glucose and free fatty acid levels, acts as a key pathogenic component in type II diabetes, contributing to β-cell dysfunction and death.
Enida Gjoni +11 more
doaj +1 more source
Eczema and ceramides: an update [PDF]
Contact Dermatitis, 2013 SummaryAlthough normal epidermal barrier function depends on numerous factors, including corneocytes, lipids, enzymes, pH, and calcium gradient, the key players are lipids and proteins in the stratum corneum. Atopic dermatitis is characterized by barrier abnormalities, such as the presence of filaggrin mutations in almost 50% of patients with moderate ...
Jungersted, Jakob Mutanu, Agner, Tove
openaire +3 more sources
Tackling cancer stemness with nanotechnology in the era of precision medicine
BMEMat, EarlyView.Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
wiley +1 more source
The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609
Journal of Lipid Research, 2004 The cytotoxic effects of several chemotherapeutic drugs have been linked to elevated de novo ceramide biosynthesis. However, the relationship between the intracellular site(s) of ceramide accumulation and cytotoxicity is poorly understood.
Ryan J. Perry, Neale D. Ridgway
doaj +1 more source
Ceramide in Plasma Membrane Repair
, 2013 The perforation of the plasmalemma by pore-forming toxins causes an influx of Ca2+ and an efflux of cytoplasmic proteins. In order to ensure cellular survival, lesions have to be identified, plugged and removed from the membrane.
Babiychuk, Eduard B. +3 more
core +1 more source
Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release
Chemistry – A European Journal, EarlyView.Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka +6 more
wiley +1 more source