Results 101 to 110 of about 72,817 (297)

Quantitative analysis of ceramide molecular species by high performance liquid chromatography

Journal of Lipid Research, 1998
A method was developed for quantitative analysis of molecular species of ceramide (N-acyl-sphingosine) and dihydroceramide (N-acyl sphinganine) by high performance liquid chromatography (HPLC).
Midori Yano, Etsu Kishida, Yuka Muneyuki, Yasuo Masuzawa   +3 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia

Journal of Lipid Research, 2005
Ceramide is a key bioactive mediator that inhibits surfactant phosphatidylcholine (PtdCho) synthesis in lung epithelia. Ceramide availability is governed by sphingomyelin (SM) hydrolysis, but less is known regarding its de novo synthesis.
Zhiwei Xu, Jiming Zhou, Diann M. McCoy, Rama K. Mallampalli   +3 more
doaj   +1 more source

Ceramide in Stress Response [PDF]

, 2010
Evidence has consistently indicated that activation of sphingomyelinases and/or ceramide synthases and the resulting accumulation of ceramide mediate cellular responses to stressors such as lipopolysaccharide, interleukin 1beta, tumor necrosis factor alpha, serum deprivation, irradiation and various antitumor treatments.
Nikolova-Karakashian, Mariana N., Rozenova, Krassimira A.   +1 more
openaire   +2 more sources

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan   +2 more
core   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

The long and the short of ceramides [PDF]

Journal of Biological Chemistry, 2018
The sphingolipid ceramide is not only a precursor of more complex sphingolipids, but also a potent signaling molecule. Specific ceramide species have distinct cellular functions, and each ceramide synthase therefore has particular roles in cells and organisms.
openaire   +2 more sources

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls

, 2016
Simon R Lea,1,* Hannah J Metcalfe,1,* Jonathan Plumb,1 Christian Beerli,2 Chris Poll,3 Dave Singh,1 Katharine H Abbott-Banner3 1Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre,
Poll C, Beerli C, Abbott-Banner KH, Plumb J, Lea SR, Metcalfe HJ, Singh D   +6 more
core  

Chemical structure of ceramide species.

, 2018
In this study, we evaluated the effect of SSE and its major component, tiliroside, on ceramide content in the SC and the expression of ceramide synthesis-related enzymes in a new reconstructed human epidermal keratinization model (3DHEEs), which we ...
Hiroshi Shimoda (461473), Shogo Takeda (482327), Toru Takarada (5832503), Genji Imokawa (747870)   +3 more
core   +1 more source