Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release
Chemistry – A European Journal, EarlyView.Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka +6 more
wiley +1 more source
Synthesis of threitol ceramide and [C-14]threitol ceramide, non-glycosidic analogues of the potent CD1d antigen alpha-galactosyl ceramide [PDF]
, 2009 The synthesis of threitol ceramide, which is a non-glycosidic analogue of the potent CD1d antigen alpha-galactosyl ceramide, is described. The synthesis of a C-14-labelled threitol ceramide analogue is also presented.
Cox, Liam; id_orcid +3 more
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]
, 2010 Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K. +2 more
core +1 more source
Grassland Research, EarlyView.Seed lipid profiles from three ryegrass cultivars infected with AR501 show distinct changes in the medium‐chain diacylglycerols, triacylglycerols and sphingolipids. The differential peal LN745.5052_5.78 can be identified as PG 16:0_18:2 with the supporting ms2 fragmentation spectrum. Abstract Background Forage perennial ryegrass (Lolium perenne L.) has
Mingshu Cao +6 more
wiley +1 more source
Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria [PDF]
, 2017 Certain fatty acids and sphingoid bases found at mucosal surfaces are known to have antibacterial activity and are thought to play a more direct role in innate immunity against bacterial infections.
Schlegel, Jan +13 more
core +1 more source
The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin [PDF]
, 2018 Yutaka Takagi,1 Xuanhe Ning,1 Akihiko Takahashi,1 Chiaki Ishizaki,2 Takahiro Nishizaka,1 Kazuhiro Kaizu,1 Masahiro Miyaki,1 Hotaka Yamamuro,1 Makoto Kawashima3 1Skin Care Product Research, Kao Corporation, Tokyo, Japan; 2Ebisu Skin Research Center ...
Yamamuro H +8 more
core
De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity [PDF]
, 2007 Previous studies could demonstrate, that the naturally occuring polyphenol resveratrol inhibits cell growth of colon carcinoma cells at least in part by inhibition of protooncogene ornithine decarboxylase (ODC). The objective of this study was to provide
Ulrich, Sandra +4 more
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Quantitative analysis of ceramide molecular species by high performance liquid chromatography
Journal of Lipid Research, 1998 A method was developed for quantitative analysis of molecular species of ceramide (N-acyl-sphingosine) and dihydroceramide (N-acyl sphinganine) by high performance liquid chromatography (HPLC).
Midori Yano +3 more
doaj +1 more source
The ART of Lowering Ceramides [PDF]
Cell Metabolism, 2015 Ceramides are lipid metabolites implicated in the metabolic dysregulation that accompanies dyslipidaemia and obesity. Using a genetic mouse model to acutely degrade ceramides in adipose tissue or the liver (i.e., by conditionally expressing acid ceramidase), in this issue of Cell MetabolismXia et al. (2015) identify roles for these molecules in insulin
openaire +2 more sources