Results 111 to 120 of about 72,817 (297)

Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. [PDF]

, 2012
Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause is the failure of an adequate acute inflammatory response as a result of impaired secretion of pro-inflammatory cytokines by ...
Walker, Ann P., Hannun, Y.A., Bloom, SL, Walker, A.P., Sewell, GW, Segal, A.W., Koster, Grielof, Sewell, Gavin W., Hannun, Yusuf A., Koster, G, Vega, R., Bielawski, Jacek, Segal, Anthony W., Koster, G., Smith, P.J., Han, X., Rahman, FZ, Postle, AD, Goss, V., Vega, R, Hannun, YA, Postle, Anthony D., Rahman, Farooq Z., Bloom, Stuart L., Walker, AP, Han, X, Vega, Roser, Smith, Philip J., Smith, PJ, Rahman, F.Z., Bielawski, J, Bloom, S.L., Bielawski, J., Goss, V, Goss, Victoria, Han, Xianlin, Sewell, G.W., Segal, AW   +37 more
core   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Coupling In vitro and In vivo Paradigm Reveals a Dose Dependent Inhibition of Angiogenesis Followed by Initiation of Autophagy by C6-Ceramide

International Journal of Biological Sciences, 2011
The activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also determined.
Rishipal R. Bansode, Mohamed Ahmedna, Kurt R. Svoboda, Jack N. Losso
doaj  

Glycolipid abnormalities in a myoclonic variant of late infantile amaurotic idiocy

Journal of Lipid Research, 1970
Glycolipids were isolated from the brain of a patient with a myoclonic variant of late infantile amaurotic idiocy. There was an abnormal glycolipid pattern in gray and white matter.
Guenter G. Bartsch
doaj   +1 more source

Impact of Albuminuria-Lowering Treatments on Cardiovascular Predictive Ceramides in Diabetes: Post Hoc Analysis of the ROTATE Trials. [PDF]

Diabetes Obes Metab
ABSTRACT Aim Cardiovascular disease (CVD) is the leading cause of mortality in individuals with diabetes. Diabetic kidney disease, closely related to CVD risk, is prevalent in up to 40% of this population. Emerging evidence suggests ceramide lipids as accurate biomarkers for CVD.
Pigsborg K, Kienle SM, Wretlind A, Rotbain Curovic V, Blond MB, Heerspink HJL, Hansen TW, Persson F, Sulek K, Legido-Quigley C, Rossing P.   +10 more
europepmc   +2 more sources

Ceramide induces apoptosis in PC12 cells [PDF]

, 1997
The novel lipid second messenger, ceramide, induced apoptosis in PC12 cells as determined morphologically by nuclear appearance and internucleosomal DNA fragmentation.
Perry J Hartfield, George C Mayne, Murray, Andrew W, Andrew W Murray, Mayne, George C, Hartfield, Perry J   +5 more
core   +1 more source

Seed lipid profiles of perennial ryegrass: Global patterns and differentiation of ryegrass cultivars and Epichloë endophytes

Grassland Research, EarlyView.
Seed lipid profiles from three ryegrass cultivars infected with AR501 show distinct changes in the medium‐chain diacylglycerols, triacylglycerols and sphingolipids. The differential peal LN745.5052_5.78 can be identified as PG 16:0_18:2 with the supporting ms2 fragmentation spectrum. Abstract Background Forage perennial ryegrass (Lolium perenne L.) has
Mingshu Cao, Wei Zhang, Wade J. Mace, Christine R. Voisey, David E. Hume, Richard D. Johnson, Sushma Prakash   +6 more
wiley   +1 more source

Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide

Cellular Physiology and Biochemistry, 2016
Background/Aims: Major depressive disorder is one of the most common diseases in western countries. The disease is mainly defined by its psychiatric symptoms.
Anne Gulbins, Heike Grassmé, Richard Hoehn, Barbara Wilker, Matthias Soddemann, Marcus Kohnen, Michael J. Edwards, Johannes Kornhuber, Erich Gulbins   +8 more
doaj   +1 more source

Biophysical studies of lipid membranes by solid state NMR and molecular dynamics simulations [PDF]

, 2013
Biological membranes separate the cell interior from the outside and have diverse functions from signal transduction, apoptosis to transportations of ions and small molecules in and out of the cell.
Dutagaci, Bercem
core  

Sphingosine, a Product of Ceramide Hydrolysis, Influences the Formation of Ceramide Channels [PDF]

, 2006
Ceramides are known to have a regulatory function in apoptosis, including the release of cytochrome c and other proapoptotic factors from the mitochondrial intermembrane space. Ceramides can form large, stable channels in the outer mitochondrial membrane,
Fluss, Sharon, Elrick, Matthew J., Colombini, Marco   +2 more
core   +1 more source