Results 111 to 120 of about 67,929 (292)

Ceramide biosynthesis and metabolism in trophoblast syncytialization [PDF]

, 2012
Sphingolipid mediators such as ceramide are pleiotropic regulators of cellular growth, differentiation and apoptosis. We investigated the role of ceramide biosynthesis, metabolism and actions in term human cytotrophoblasts syncytialized over 7 days in ...
Singh, A., Keelan, J., Aye, I., Dharmarajan, Arunasalam   +3 more
core   +1 more source

Ceramide as a Promising Tool for Diagnosis and Treatment of Clinical Diseases: A Review of Recent Advances

Metabolites
Background/Objectives: Ceramide, a sphingolipid metabolite, has emerged as a key player in various physiological and pathological processes. Changes in ceramide levels are associated with the occurrence and development of various diseases, highlighting ...
Xueping Shen, Rui Feng, Rui Zhou, Zhaoyang Zhang, Kaiyong Liu, Sheng Wang   +5 more
doaj   +1 more source

Metabolic Messengers: ceramides

Nature Metabolism, 2019
Ceramides are products of metabolism that accumulate in individuals with obesity or dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when prolonged, elicit the tissue dysfunction that underlies diabetes and heart disease.
Scott A. Summers, Bhagirath Chaurasia, William L. Holland   +2 more
openaire   +3 more sources

Ceramide induces apoptosis in PC12 cells [PDF]

, 1997
The novel lipid second messenger, ceramide, induced apoptosis in PC12 cells as determined morphologically by nuclear appearance and internucleosomal DNA fragmentation.
Perry J Hartfield, George C Mayne, Murray, Andrew W, Andrew W Murray, Mayne, George C, Hartfield, Perry J   +5 more
core   +1 more source

LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia

Journal of Lipid Research, 2005
Ceramide is a key bioactive mediator that inhibits surfactant phosphatidylcholine (PtdCho) synthesis in lung epithelia. Ceramide availability is governed by sphingomyelin (SM) hydrolysis, but less is known regarding its de novo synthesis.
Zhiwei Xu, Jiming Zhou, Diann M. McCoy, Rama K. Mallampalli   +3 more
doaj   +1 more source

Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects

iMeta, EarlyView.
Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni, Jiaojiao Xie, Zhichun Zhang, Keming Zhang, Jie Ding, Mingyang Chang, Ying Su, Yunan Zhang, Mingfei Yao, Chengyuan Wang, Yan Yan, Wenjie Fang, Hainv Gao, Xuecong Tian, Yangshuo Li, Xinlin Zhu, Wen Zhang, Wanqing Liao, Gaoyuan Xu, Guojing Chen, Xiaoyi Lv, Chaoqin Yu, Weihua Pan, Vadim Molodtsov, Lanjuan Li, Yue Gao, Wei Zhou   +26 more
wiley   +1 more source

Sphingosine, a Product of Ceramide Hydrolysis, Influences the Formation of Ceramide Channels [PDF]

, 2006
Ceramides are known to have a regulatory function in apoptosis, including the release of cytochrome c and other proapoptotic factors from the mitochondrial intermembrane space. Ceramides can form large, stable channels in the outer mitochondrial membrane,
Fluss, Sharon, Elrick, Matthew J., Colombini, Marco   +2 more
core   +1 more source

Chemotherapy with ceramide in TNBC

Oncoscience, 2015
Metastasis remains the major cause of cancer-related mortality, and currently there is a lack of therapies to eliminate this risk. Therefore, it is of crucial interest to better understand this multi-step cellular process and find the best markers to identify patients who will develop early and distant relapse.
Legembre, Patrick, Micheau, Olivier, Ségui, Bruno   +2 more
openaire   +3 more sources

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Molecular Mechanisms of Ceramide-Mediated CD95 Clustering [PDF]

, 2001
The pattern of peptidoglycan (murein) segregation in Receptor clustering has been suggested as a crucial mechanism to initiate receptor signaling. Here we show that ceramide in sphingolipid-rich membrane rafts mediates clustering of CD95.
Schwarz, H., Grassmé , H., Gulbins, E.
core   +1 more source