Results 121 to 130 of about 67,929 (292)

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

iNew Medicine, EarlyView.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng, Wenhui Zhao, Min Wang, Xianwen Wang   +3 more
wiley   +1 more source

Coupling In vitro and In vivo Paradigm Reveals a Dose Dependent Inhibition of Angiogenesis Followed by Initiation of Autophagy by C6-Ceramide

International Journal of Biological Sciences, 2011
The activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also determined.
Rishipal R. Bansode, Mohamed Ahmedna, Kurt R. Svoboda, Jack N. Losso
doaj  

Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

iScience
Summary: Mechanisms by which Porphyromonas gingivalis (P. gingivalis) infection enhances oral tumor growth or resistance to cell death remain elusive. Here, we determined that P.
Megan Sheridan, Nityananda Chowdhury, Bridgette Wellslager, Natalia Oleinik, Mohamed Faisal Kassir, Han G. Lee, Mindy Engevik, Yuri Peterson, Subramanya Pandruvada, Zdzislaw M. Szulc, Özlem Yilmaz, Besim Ogretmen   +11 more
doaj   +1 more source

Glycolipid abnormalities in a myoclonic variant of late infantile amaurotic idiocy

Journal of Lipid Research, 1970
Glycolipids were isolated from the brain of a patient with a myoclonic variant of late infantile amaurotic idiocy. There was an abnormal glycolipid pattern in gray and white matter.
Guenter G. Bartsch
doaj   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells. [PDF]

, 2007
We evaluated how increased levels of ceramide kinase (CerK) would impact the growth of COS-1 fibroblasts and RBL-2H3 basophils. The low CerK activity in these cells was strongly up-regulated upon recombinant expression of CerK.
Schanzer, Andrea, Bornancin, Frederic, Graf, Christine, Tauzin, Loic, Rovina, Philipp   +4 more
core  

Ceramide 1-phosphate/ceramide, a switch between life and death [PDF]

, 2006
Ceramide is a well-characterized sphingolipid metabolite and second messenger that participates in numerous biological processes. In addition to serving as a precursor to complex sphingolipids, ceramide is a potent signaling molecule capable of ...
Gómez-Muñoz, Antonio
core   +1 more source

Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide

Cellular Physiology and Biochemistry, 2016
Background/Aims: Major depressive disorder is one of the most common diseases in western countries. The disease is mainly defined by its psychiatric symptoms.
Anne Gulbins, Heike Grassmé, Richard Hoehn, Barbara Wilker, Matthias Soddemann, Marcus Kohnen, Michael J. Edwards, Johannes Kornhuber, Erich Gulbins   +8 more
doaj   +1 more source

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Astrocytic ceramide as possible indicator of neuroinflammation [PDF]

, 2019
frontotemporal lobar dementia (FTLD) are characterized by progressive neuronal loss but differ in their underlying pathological mechanisms. However, neuroinflammation is commonly observed within these different forms of dementia.
de Wit, N.M., Vries, H.E. (Helga) de, de Wit, NM, Mulder, M.T. (Monique), Martínez-Martínez, P. (Pilar), Rozemuller, AJ, Monique T. Mulder, Helga E. de Vries, Mulder, Monique, Rozemuller, Annemieke J., de Vries, HE, Martinez-Martinez, Pilar, Sandra den Hoedt, de Vries, Helga E., Martinez-Martinez, P, de Wit, Nienke M., Mulder, Monique T., Pilar Martinez-Martinez, Rozemuller, A.J.M. (Annemieke), Nienke M. de Wit, Annemieke J. Rozemuller, Hoedt, S.M. (S.) den, den Hoedt, Sandra   +22 more
core   +1 more source