Results 121 to 130 of about 67,708 (303)

Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis

Allergy, EarlyView.
ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki, Kazunari Sugita, Zenas Yiu, Sandra Díez‐Ribas, Irene Garcia‐Jimenez, Emma Guttman‐Yassky, Luis F. Santamaria‐Babí   +6 more
wiley   +1 more source

lifs-tools/ils-ceramide-ring-trial: Release 1.0

<h1>ILS Ceramide Ring Trial Results Evaluation Pipeline</h1> <p>This is the release 1.0 of the ILS Ceramide Ring Trial Results Evaluation Pipeline.</p> <h2>Prerequisites</h2> <p>The evaluation code requires R 4.3
Bo Burla, Nils Hoffmann
core   +1 more source

Mouse anti-ceramide antiserum: A specific tool for the detection of endogenous ceramide

, 2001
Ceramide is a pivotal molecule in signal transduction and an essential structural component of the epidermal permeability barrier. The epidermis is marked by a high concentration of ceramide and by a unique spectrum of ceramide species: Besides the two ...
Wepf, Roger, R. Wepf, Brade, Lore, Wittern, Klaus-Peter, Pfeiffer, Stephan, Lindner, Buko, G. Vielhaber, B. Lindner, Brade, Helmut, U. Hintze, Hintze, Ulrich, Vielhaber, Gabriele, S. Pfeiffer, K.-P. Wittern, H. Brade, L. Brade   +15 more
core   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Synthesis of threitol ceramide and [C-14]threitol ceramide, non-glycosidic analogues of the potent CD1d antigen alpha-galactosyl ceramide

, 2009
The synthesis of threitol ceramide, which is a non-glycosidic analogue of the potent CD1d antigen alpha-galactosyl ceramide, is described. The synthesis of a C-14-labelled threitol ceramide analogue is also presented.
Cox, Liam; id_orcid, Besra, Gurdyal; id_orcid, Diaz, YRG, Wojno, J   +3 more
core   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan   +2 more
core   +1 more source

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

Cancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah, Mackenzie M. Mayhew, Jacob Sellers, Russell G. Witt   +3 more
wiley   +1 more source

Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria

, 2017
Certain fatty acids and sphingoid bases found at mucosal surfaces are known to have antibacterial activity and are thought to play a more direct role in innate immunity against bacterial infections.
Schlegel, Jan, Sauer, Markus, Seibel, Jürgen, Jan Schlegel, Walter, Tim, Markus Sauer, Becam, Jérôme, Anne Burgert, Jürgen Seibel, Alexandra Schubert-Unkmeir, Jérôme Becam, Schubert-Unkmeir, Alexandra, Tim Walter, Burgert, Anne   +13 more
core   +1 more source

Absorption and Effects of Patch Test Preparations of Hydroperoxides of Limonene and Hydroperoxides of Linalool in Human Ex Vivo Skin

Contact Dermatitis, EarlyView.
This study mimics clinical patch testing for the diagnosis of allergic contact dermatitis, by application of patch test preparations of fragrance terpenes to ex vivo human skin samples. The study investigates the penetration of linalool hydroperoxide and limonene hydroperoxide in skin, alongside an analysis of the lipid‐modifying effects of the patch ...
Aoife Clancy, Lina Hagvall, Per Malmberg, Niamh M. O'Boyle   +3 more
wiley   +1 more source