Results 91 to 100 of about 67,708 (303)

Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

Journal of Lipid Research, 2013
Light-induced retinal degeneration (LIRD) in albino rats causes apoptotic photoreceptor cell death. Ceramide is a second messenger for apoptosis. We tested whether increases in ceramide mediate photoreceptor apoptosis in LIRD and if inhibition of ...
Hui Chen, Julie-Thu A. Tran, Annette Eckerd, Tuan-Phat Huynh, Michael H. Elliott, Richard S. Brush, Nawajes A. Mandal   +6 more
doaj   +1 more source

Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans

BMJ Open Diabetes Research & Care, 2020
Introduction Sphingolipid accumulation has been linked to obesity, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). A recent study showed that depletion of dihydroceramide desaturase-1 (DES-1) in adipose and/or liver tissue decreases ...
Irene Esposito, Michael Roden, Christian Herder, Maria Apostolopoulou, Ruth Gordillo, Sofiya Gancheva, Klaus Strassburger, Matthias Schlensak, Philipp E Scherer   +8 more
doaj   +1 more source

Plasma ceramide profile.

, 2016
Plasma ceramide species were measured by LC/ESI/MS/MS analysis. (A) Ceramide profiles are shown as a heat map similar to above. Ceramide concentrations were log-transformed prior to computing z-scores.
Atif A. Khan (3159315), Sanjay B. Maggirwar (244853), Juilee Thakar (31567), Norman J. Haughey (193998), Michael C. Keefer (102279), Bo Zheng (170888), Diane Morse (3159306), William Valenti (3159309), James J. Kobie (170879), Brittany Carter (3159312), Alexander F. Rosenberg (170904), Memorie Samuel (3159318), Christopher Fucile (847327), Catherine Bunce (254194), Michael S. Piepenbrink (754729), Michelle Kiebala (244844)   +15 more
core   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism[S]

Journal of Lipid Research, 2017
Macrophages use an extracellular, hydrolytic compartment formed by local actin polymerization to digest aggregated LDL (agLDL). Catabolism of agLDL promotes foam cell formation and creates an environment rich in LDL catabolites, including cholesterol and
Rajesh K. Singh, Abigail S. Haka, Alexandria Brumfield, Inna Grosheva, Priya Bhardwaj, Harvey F. Chin, Yuquan Xiong, Timothy Hla, Frederick R. Maxfield   +8 more
doaj   +1 more source

Regulation of neutral ceramidase in glomerular messangial cells

, 2009
During the past several years, ceramide has emerged as an important second messenger triggering cell responses including proliferation, differentiation, growth arrest and apoptosis.
Franzen, Rochus
core  

Presentation_1_Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody.pptx

, 2019
Ceramide-rich platforms (CRPs) mediate association of proteins with the sphingolipid ceramide and may regulate protein interaction in membrane contact sites to the cytoskeleton, organelles, and infectious pathogens.
Xue Jiang (411020), Stefanka D. Spassieva (7254386), Guanghu Wang (647233), Zhihui Zhu (210406), Liansheng Zhong (7254374), Erhard Bieberich (491171), Haiyan Qin (1371060), Priyanka Tripathi (806983), Simone M. Crivelli (7254383), Wenbo Zhi (482439), Sanjib Karki (7254380), Ahmed Elsherbini (7254377)   +11 more
core   +1 more source

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization Mechanism

, 2017
Ceramide is a sphingolipid involved in several cellular processes, including apoptosis. It has been proposed that ceramide forms large and stable channels in the mitochondrial outer membrane that induce cell death through direct release of cytochrome c ...
David Gil, Artetxe, I., Gil, D., Alonso, A., García-Sáez, A. ; https://orcid.org/, Félix M. Goñi, Ibai Artetxe, Mikel Valle, Alicia Alonso, Ugarte-Uribe, B., Valle, M., Ana J. García-Sáez, Begoña Ugarte-Uribe, Goñi, F.   +13 more
core   +1 more source