Results 91 to 100 of about 67,929 (292)

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Characterization of genes involved in ceramide metabolism in the Pacific oyster (Crassostrea gigas)

BMC Research Notes, 2012
Background The lipid signaling molecule, ceramide, is a key component of the vertebrate stress response, however, there is limited information concerning its role in invertebrate species.
Timmins-Schiffman Emma, Roberts Steven
doaj   +1 more source

Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans

BMJ Open Diabetes Research & Care, 2020
Introduction Sphingolipid accumulation has been linked to obesity, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). A recent study showed that depletion of dihydroceramide desaturase-1 (DES-1) in adipose and/or liver tissue decreases ...
Irene Esposito, Michael Roden, Christian Herder, Maria Apostolopoulou, Ruth Gordillo, Sofiya Gancheva, Klaus Strassburger, Matthias Schlensak, Philipp E Scherer   +8 more
doaj   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. [PDF]

, 2012
Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause is the failure of an adequate acute inflammatory response as a result of impaired secretion of pro-inflammatory cytokines by ...
Walker, Ann P., Hannun, Y.A., Bloom, SL, Walker, A.P., Sewell, GW, Segal, A.W., Koster, Grielof, Sewell, Gavin W., Hannun, Yusuf A., Koster, G, Vega, R., Bielawski, Jacek, Segal, Anthony W., Koster, G., Smith, P.J., Han, X., Rahman, FZ, Postle, AD, Goss, V., Vega, R, Hannun, YA, Postle, Anthony D., Rahman, Farooq Z., Bloom, Stuart L., Walker, AP, Han, X, Vega, Roser, Smith, Philip J., Smith, PJ, Rahman, F.Z., Bielawski, J, Bloom, S.L., Bielawski, J., Goss, V, Goss, Victoria, Han, Xianlin, Sewell, G.W., Segal, AW   +37 more
core   +1 more source

Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I

Journal of Lipid Research, 2006
Ceramide is a component of the sphingomyelin cycle and a well-established lipid signaling molecule. We recently reported that ceramide specifically increased ABCA1-mediated cholesterol efflux to apolipoprotein A-I (apoA-I), a critical process that leads ...
Amy B. Ghering, W. Sean Davidson
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

lifs-tools/ils-ceramide-ring-trial: Release 1.0 [PDF]

<h1>ILS Ceramide Ring Trial Results Evaluation Pipeline</h1> <p>This is the release 1.0 of the ILS Ceramide Ring Trial Results Evaluation Pipeline.</p> <h2>Prerequisites</h2> <p>The evaluation code requires R 4.3
Bo Burla, Nils Hoffmann
core   +1 more source

Mouse anti-ceramide antiserum: A specific tool for the detection of endogenous ceramide [PDF]

, 2001
Ceramide is a pivotal molecule in signal transduction and an essential structural component of the epidermal permeability barrier. The epidermis is marked by a high concentration of ceramide and by a unique spectrum of ceramide species: Besides the two ...
Wepf, Roger, R. Wepf, Brade, Lore, Wittern, Klaus-Peter, Pfeiffer, Stephan, Lindner, Buko, G. Vielhaber, B. Lindner, Brade, Helmut, U. Hintze, Hintze, Ulrich, Vielhaber, Gabriele, S. Pfeiffer, K.-P. Wittern, H. Brade, L. Brade   +15 more
core   +1 more source

The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609

Journal of Lipid Research, 2004
The cytotoxic effects of several chemotherapeutic drugs have been linked to elevated de novo ceramide biosynthesis. However, the relationship between the intracellular site(s) of ceramide accumulation and cytotoxicity is poorly understood.
Ryan J. Perry, Neale D. Ridgway
doaj   +1 more source