Results 71 to 80 of about 67,708 (303)
Ceramide in cerebrovascular diseases [PDF]
, 2023 Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway.
Huiqi Yuan +3 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley +1 more source
Concise synthesis of α-galactosyl ceramide from d-galactosyl iodide and d-lyxose
, 2013 α-Galactosyl ceramide is synthesized from d-lyxose in 32% overall yield in five steps. The short and efficient protocol involves a one-pot protection and glycosidation of d-lyxose with d-galactosyl iodide as a key step. The α-linked disaccharide obtained
LUO, SY +7 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.ErZhi formula (EZF) is composed of Ligustri Lucidi Fructus (LLF) and Ecliptae herba (EH). Ovariectomized (OVX) and sham rats received 12‐week intragastric treatment with EZF, alendronate, and vehicle saline. Gastrocnemius tissues were harvested to systematically evaluate pharmacodynamic changes in skeletal muscle morphology, mitochondrial ...
Yuqing Pang +7 more
wiley +1 more source
Roles and therapeutic targeting of ceramide metabolism in cancer
Molecular MetabolismBackground: Ceramides are sphingolipids that act as signaling molecules involved in regulating cellular processes including apoptosis, proliferation, and metabolism.
Narendra Wajapeyee +2 more
doaj +1 more source
Journal of Lipid Research, 1972 Methylation analysis of ceramide tetrasaccharide isolated from human erythrocytes gave acetates of 2,3,6-tri-O-methylgalactitol and 2,4,6-tri-O-methylgalactitol in a ratio of 1 : 1, and about 50% of the galactose was oxidized by periodate.
Bader Siddiqui +3 more
doaj +1 more source
C6-ceramide Inhibits the Motility of Anaplastic Thyroid Carcinoma Cells [PDF]
Background: Anaplastic thyroid carcinoma (ATC) is an aggressive type of thyroid cancer, and its metastasis requires cell motility. Ceramide is involved in a variety of biological processes, including inflammation, cell signaling, cell motility, and ...
Kataoka, Hideyuki +26 more
core +1 more source
Ceramide-1-phosphate protection of cochlear hair cells against cisplatin ototoxicity
Toxicology Reports, 2016 Background: Ceramide-1-phosphate (C1P) is a phosphorylated form of ceramide. While ceramide is known to be an inducer of apoptosis of cochlear hair cells in cisplatin ototoxicity, little is known about the function of C1P in cochlear diseases.
Quang Le, Keiji Tabuchi, Akira Hara
doaj +1 more source
Animal Research and One Health, EarlyView.Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar +8 more
wiley +1 more source
Characterization of genes involved in ceramide metabolism in the Pacific oyster (
BMC Research Notes, 2012 Background The lipid signaling molecule, ceramide, is a key component of the vertebrate stress response, however, there is limited information concerning its role in invertebrate species.
Timmins-Schiffman Emma, Roberts Steven
doaj +1 more source