Results 31 to 40 of about 74,862 (301)

Turnover of endogenous ceramide in cultured normal and Farber fibroblasts

Journal of Lipid Research, 1997
De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine.
G van Echten-Deckert, A Klein, T Linke, T Heinemann, J Weisgerber, K Sandhoff   +5 more
doaj   +1 more source

Ceramide is More Effective than Shea Butter in Maintaining Skin Acidity

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2022
Background: Skin is the largest organ that functions as a physical barrier. Stable skin pH can maximize its function. Ceramide and shea butter cream have components that maintain the skin pH in the stratum corneum. Purpose: The aim is to compare ceramide
Zilpa Widyastuti, Suci Widhiati
doaj   +1 more source

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody

Frontiers in Cell and Developmental Biology, 2019
Ceramide-rich platforms (CRPs) mediate association of proteins with the sphingolipid ceramide and may regulate protein interaction in membrane contact sites to the cytoskeleton, organelles, and infectious pathogens.
Xue Jiang, Xue Jiang, Zhihui Zhu, Haiyan Qin, Priyanka Tripathi, Liansheng Zhong, Liansheng Zhong, Ahmed Elsherbini, Sanjib Karki, Simone M. Crivelli, Wenbo Zhi, Guanghu Wang, Stefanka D. Spassieva, Erhard Bieberich   +13 more
doaj   +1 more source

Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy

European Journal of Cell Biology, 2023
Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their ...
Javad Alizadeh, Simone C. da Silva Rosa, Xiaohui Weng, Joadi Jacobs, Shahrokh Lorzadeh, Amir Ravandi, Rui Vitorino, Stevan Pecic, Aleksandra Zivkovic, Holger Stark, Shahla Shojaei, Saeid Ghavami   +11 more
openaire   +3 more sources

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

, 2005
Current understanding of IGF-I-mediated neuroprotection implies the activation of phosphatidylinositol-3-kinase (PI-3K), which leads to the activation of Akt/Protein Kinase B.
Brugg, B., Arbez, N., Willaime-Morawek, S., Mariani, J.   +3 more
core   +1 more source

Developmental Comparison of Ceramide in Wild-Type and Cln3Δex7/8 Mouse Brains and Sera

Frontiers in Neurology, 2019
CLN3 disease is a neurodevelopmental disease leading to early visual failure, motor decline, and death. CLN3 pathogenesis has been linked to dysregulation of ceramide, a key intracellular messenger impacting various biological functions.
Sally El-Sitt, Jihane Soueid, Jamal Al Ali, Joelle Makoukji, Nadine J. Makhoul, Hayat Harati, Rose-Mary Boustany   +6 more
doaj   +1 more source

Separation of neutral glycosphingolipids and sulfatides by thin-layer chromatography

Journal of Lipid Research, 1967
Two one-dimensional systems for separation of glycolipids from total lipid extracts of tissues by thin-layer chromatography are described. System I used, as adsorbent, an alkaline mixture of silica gel without CaSO4 binder (75%) and magnesium silicate ...
Vladimir P. Skipski, Anson F. Smolowe, Marion Barclay   +2 more
doaj   +1 more source

Ceramide mediates radiation-induced germ cell apoptosis via regulating mitochondria function and MAPK factors in Caenorhabditis elegans

Ecotoxicology and Environmental Safety, 2021
Studies about radiation damage in vivo are very significant for healthy risk assessment as well as cancer radiotherapy. Ceramide as a second messenger has been found to be related to radiation-induced apoptosis. However, the detailed mechanisms in living
Yaning Yang, Guangmin Xu, Yun Xu, Xiaowen Cheng, Shengmin Xu, Shaopeng Chen, Lijun Wu   +6 more
doaj   +1 more source

Ceramide and Ischemia/Reperfusion Injury [PDF]

, 2018
Ceramide, a bioactive membrane sphingolipid, functions as an important second messenger in apoptosis and cell signaling. In response to stresses, it may be generated by de novo synthesis, sphingomyelin hydrolysis, and/or recycling of complex ...
Xingxuan He, Edward H. Schuchman
core   +1 more source

Characterization of neutral sphingolipids from chicken erythrocytes.

Journal of Lipid Research, 1985
The neutral sphingolipids from chicken erythrocytes were characterized. The total concentration of neutral sphingolipids was found to be 480 nmol/g of dry stroma.
T Shiraishi, Y Uda
doaj   +1 more source