Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes
Journal of Lipid Research, 2018 We reported that amyloid β peptide (Aβ42) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes.
Ji-Na Kong +13 more
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Ceramide Kinase and Ceramide‐1‐Phosphate
, 2007 It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK).
Dayanjan S, Wijesinghe +3 more
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Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties [PDF]
, 2015 This work was supported by National Institute of Mental Health grants: P30 MH075673-06 to BSS, CR, NJH and JCM; R01 MH096636 and R01 MH077542 to NJH (http://projectreporter.nih.gov/reporter.cfm); and The Johns Hopkins Brain Science Institute to BSS ...
Justin C. McArthur (66539) +35 more
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C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia. [PDF]
PLoS ONE, 2013 Ceramide is a sphingolipid metabolite that induces cancer cell death. When C6-ceramide is encapsulated in a nanoliposome bilayer formulation, cell death is selectively induced in tumor models. However, the mechanism underlying this selectivity is unknown.
Lindsay K Ryland +16 more
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Turnover of endogenous ceramide in cultured normal and Farber fibroblasts
Journal of Lipid Research, 1997 De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine.
G van Echten-Deckert +5 more
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Concise synthesis of α-galactosyl ceramide from d-galactosyl iodide and d-lyxose [PDF]
, 2013 α-Galactosyl ceramide is synthesized from d-lyxose in 32% overall yield in five steps. The short and efficient protocol involves a one-pot protection and glycosidation of d-lyxose with d-galactosyl iodide as a key step. The α-linked disaccharide obtained
LUO, SY +7 more
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Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia [PDF]
, 2023 Acute myelogenous leukemia (AML), the most prevalent acute and aggressive leukemia diagnosed in adults, often recurs as a difficult-to-treat, chemotherapy-resistant disease.
Johnson Ung +38 more
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Ceramide is More Effective than Shea Butter in Maintaining Skin Acidity
Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2022 Background: Skin is the largest organ that functions as a physical barrier. Stable skin pH can maximize its function. Ceramide and shea butter cream have components that maintain the skin pH in the stratum corneum. Purpose: The aim is to compare ceramide
Zilpa Widyastuti, Suci Widhiati
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Frontiers in Cell and Developmental Biology, 2019 Ceramide-rich platforms (CRPs) mediate association of proteins with the sphingolipid ceramide and may regulate protein interaction in membrane contact sites to the cytoskeleton, organelles, and infectious pathogens.
Xue Jiang +13 more
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Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
European Journal of Cell Biology, 2023 Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These mechanisms of regulation, however, appear to be context dependent in terms of ceramides' fatty acid chain length, subcellular localization, and the presence or absence of their ...
Javad Alizadeh +11 more
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