Results 31 to 40 of about 67,708 (303)
Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury
JCI Insight, 2023 The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear.
Irina Petrache +13 more
doaj +1 more source
, 2021 Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive sphingomyelinases is a hallmark of adaptive responses and cellular repair.
Martin S. Winkler (3545657) +9 more
core +1 more source
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
Ceramide in the prostate [PDF]
Cancer Biology & Therapy, 2013 The nomenclature for the serine/threonine protein phosphatases was established by Professor Sir Philip Cohen over 30 years ago. (1) At that time protein phosphatase 1 was known to have two small inhibitory proteins (I-1 and I-2) and be regulated by sub-cellular location whereas no protein inhibitor had yet been discovered for the related multi-subunit ...
openaire +2 more sources
Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway
Journal of Pharmacological Sciences, 2010 .: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromatography using
Eiko Tada +7 more
doaj +1 more source
Advances in determining signaling mechanisms of ceramide and role in disease
Journal of Lipid Research, 2019 Ceramide is a critical bioactive lipid involved in diverse cellular processes. It has been proposed to regulate cellular processes by influencing membrane properties and by directly interacting with effector proteins.
Jeffrey L. Stith +2 more
doaj +1 more source
Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes
Journal of Lipid Research, 2018 We reported that amyloid β peptide (Aβ42) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes.
Ji-Na Kong +13 more
doaj +1 more source
C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia. [PDF]
PLoS ONE, 2013 Ceramide is a sphingolipid metabolite that induces cancer cell death. When C6-ceramide is encapsulated in a nanoliposome bilayer formulation, cell death is selectively induced in tumor models. However, the mechanism underlying this selectivity is unknown.
Lindsay K Ryland +16 more
doaj +1 more source
Ceramide Kinase and Ceramide‐1‐Phosphate
, 2007 It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK).
Dayanjan S, Wijesinghe +3 more
openaire +3 more sources
Turnover of endogenous ceramide in cultured normal and Farber fibroblasts
Journal of Lipid Research, 1997 De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine.
G van Echten-Deckert +5 more
doaj +1 more source