Results 11 to 20 of about 67,708 (303)
The targeting of plasmalemmal ceramide to mitochondria during apoptosis. [PDF]
PLoS ONE, 2011 Ceramide is a key lipid mediator of cellular processes such as differentiation, proliferation, growth arrest and apoptosis. During apoptosis, ceramide is produced within the plasma membrane.
Eduard B Babiychuk +6 more
doaj +3 more sources
Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy
Cell Reports, 2018 Summary: Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is unclear.
Stanley M. Walls +5 more
doaj +2 more sources
The structural requirements for ceramide activation of serine-threonine protein phosphatases
Journal of Lipid Research, 2004 The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E Chalfant +2 more
exaly +3 more sources
Journal of Lipid Research, 2008 Increased mitochondrial ceramide levels are associated with the initiation of apoptosis. There is evidence that ceramide is causal. Thus, the conversion of the precursor, dihydroceramide, to ceramide by the enzyme dihydroceramide desaturase may be ...
Johnny Stiban, Marco Colombini
exaly +3 more sources
Trends in Biochemical Sciences, 1999 Ceramide is a sphingosine-based lipid second messeger molecule that is involved in regulation of differentiation, proliferation, apoptosis, or growth arrest.
Centi, C, Cifone, MG, DI MARZIO, Luisa
core +5 more sources
Development and characterization of a novel anti-ceramide antibody
Journal of Lipid Research, 2007 Ceramide is emerging as a key sphingolipid that regulates a variety of cellular processes. To facilitate the study of ceramide localization and its interaction with cellular proteins, we have developed a novel antibody against ceramide.
Kannan Krishnamurthy +2 more
exaly +3 more sources
Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. [PDF]
PLoS ONE, 2016 Here, we studied the underlying mechanism of aldosterone (Aldo)-induced vascular endothelial cell damages by focusing on ceramide. We confirmed that Aldo (at nmol/L) inhibited human umbilical vein endothelial cells (HUVEC) survival, and induced ...
Yumei Zhang +7 more
doaj +1 more source
Cells, 2022 Since ceramide is a key epidermal barrier constituent and its deficiency causes barrier-compromised skin, several molecular types of ceramides are formulated in commercial topical agents to improve barrier function. Topical ceramide localizes on the skin
Kyong-Oh Shin +4 more
doaj +1 more source
Journal of Biological Chemistry, 2011 Intensive research over the past 2 decades has implicated ceramide in the regulation of several cell responses. However, emerging evidence points to dramatic complexities in ceramide metabolism and structure that defy the prevailing unifying hypothesis on ceramide function that is based on the understanding of ceramide as a single entity.
Yusuf A, Hannun, Lina M, Obeid
openaire +2 more sources
Ceramide and ceramide 1-phosphate in health and disease [PDF]
Lipids in Health and Disease, 2010 AbstractSphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction of apoptosis.
Gómez-Muñoz Antonio +4 more
openaire +4 more sources