Results 11 to 20 of about 74,862 (301)

Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy

Cell Reports, 2018
Summary: Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is unclear.
Stanley M. Walls, Anthony Cammarato, Dale A. Chatfield, Karen Ocorr, Greg L. Harris, Rolf Bodmer   +5 more
doaj   +2 more sources

Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway

Journal of Pharmacological Sciences, 2010
.: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromatography using
Eiko Tada, Kaori Toyomura, Hiroyuki Nakamura, Hirotsune Sasaki, Takeshi Saito, Masayuki Kaneko, Yasunobu Okuma, Toshihiko Murayama   +7 more
doaj   +2 more sources

Ceramide and apoptosis

Biochemical Society Transactions, 1999
Ceramide is a sphingosine-based lipid second messeger molecule that is involved in regulation of differentiation, proliferation, apoptosis, or growth arrest.
R, Kolesnick, Y A, Hannun
core   +5 more sources

Ceramide and ceramide 1-phosphate in health and disease [PDF]

Lipids in Health and Disease, 2010
AbstractSphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction of apoptosis.
Gómez-Muñoz Antonio, Trueba Miguel, Ouro Alberto, Gangoiti Patricia, Arana Lide   +4 more
openaire   +4 more sources

Ceramide-1-Phosphate Is Involved in Therapy-Induced Senescence

, 2022
Sphingolipids are key signaling lipids and their dysregulation has been associated with various cellular processes. We have previously shown significant changes in sphingolipids in therapy-induced senescence, a state of cell cycle arrest as a response to
Jonna Frasor (841097), G. Ekin Atilla-Gokcumen (1646659), Nicole Colon-Rosa, Alec Millner (12323222), Logan Running (12323225), Alec Millner, G. Ekin Atilla-Gokcumen, Logan Running, Diana S. Aga, Nicole Colon-Rosa (12323228), Diana S. Aga (1616572), Jonna Frasor   +11 more
core   +1 more source

C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]

, 2003
Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B., Caboche, J., Willaime-Morawek, S., Brami-Cherrier, K., Mariani, J.   +4 more
core   +1 more source

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure [PDF]

, 2012
Contains fulltext : 107961.pdf (Publisher’s version ) (Open Access)Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Dinkla, S., Brock, R.E., Dinkla, S, Cluitmans, JC, Fuchs, B, Joosten, I, Fransen, J., Tomelleri, C, Verdurmen, W.P.R., Bosman, G.J.C.G.M., Wessels, K, Schiller, J., Wessels, K., Brock, R, Fuchs, B., Verdurmen, WP, Joosten, I., Bosman, GJ, Cluitmans, J.C.A., Schiller, J, Tomelleri, C., Fransen, J   +21 more
core   +1 more source

DataSheet_1_Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies.docx

, 2021
Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive sphingomyelinases is a hallmark of adaptive responses and cellular repair.
Martin S. Winkler (3545657), Heike Hofmann-Winkler (797086), Markus H. Gräler (11855987), Stefan Pöhlmann (142445), Michael Bauer (115390), Murad Abusukhun (11855984), Konrad Meissner (64927), Björn Tampe (790842), Onnen Moerer (4991669), Ralf A. Claus (124228)   +9 more
core   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source