Results 11 to 20 of about 67,929 (292)
Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy [PDF]
Cell Reports, 2018 Summary: Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is unclear.
Stanley M. Walls +5 more
doaj +2 more sources
Trends in Biochemical Sciences, 1999 Ceramide is a sphingosine-based lipid second messeger molecule that is involved in regulation of differentiation, proliferation, apoptosis, or growth arrest.
R, Kolesnick, Y A, Hannun
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Ceramide-1-Phosphate Is Involved in Therapy-Induced Senescence [PDF]
, 2022 Sphingolipids are key signaling lipids and their dysregulation has been associated with various cellular processes. We have previously shown significant changes in sphingolipids in therapy-induced senescence, a state of cell cycle arrest as a response to
Jonna Frasor (841097) +11 more
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DataSheet_1_Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies.docx [PDF]
, 2021 Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive sphingomyelinases is a hallmark of adaptive responses and cellular repair.
Martin S. Winkler (3545657) +9 more
core +1 more source
Journal of Biological Chemistry, 2011 Intensive research over the past 2 decades has implicated ceramide in the regulation of several cell responses. However, emerging evidence points to dramatic complexities in ceramide metabolism and structure that defy the prevailing unifying hypothesis on ceramide function that is based on the understanding of ceramide as a single entity.
Yusuf A, Hannun, Lina M, Obeid
openaire +2 more sources
Ceramide and ceramide 1-phosphate in health and disease [PDF]
Lipids in Health and Disease, 2010 AbstractSphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction of apoptosis.
Gómez-Muñoz Antonio +4 more
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C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]
, 2003 Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B. +4 more
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IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2? [PDF]
, 2005 Current understanding of IGF-I-mediated neuroprotection implies the activation of phosphatidylinositol-3-kinase (PI-3K), which leads to the activation of Akt/Protein Kinase B.
Brugg, B. +3 more
core +1 more source
ROLE OF CERAMIDE IN TRANSFERRIN RECEPTOR MOVEMENT IN THE PLANE OF THE PLASMA MEMBRANE [PDF]
Assiut Veterinary Medical Journal, 2010 After ligation with transferrin (Tf), transferrin receptor (TfR) is aggregated on cell surface in clathrin coated pits and then internalized into the cell.
RANA ALAWADHI, A-B.M. ABDEL-SHAKOR
doaj +1 more source
Ceramide in the prostate [PDF]
Cancer Biology & Therapy, 2013 The nomenclature for the serine/threonine protein phosphatases was established by Professor Sir Philip Cohen over 30 years ago. (1) At that time protein phosphatase 1 was known to have two small inhibitory proteins (I-1 and I-2) and be regulated by sub-cellular location whereas no protein inhibitor had yet been discovered for the related multi-subunit ...
openaire +2 more sources