Results 21 to 30 of about 74,862 (301)
Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury
JCI Insight, 2023 The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear.
Irina Petrache +13 more
doaj +1 more source
Development and characterization of a novel anti-ceramide antibody
Journal of Lipid Research, 2007 Ceramide is emerging as a key sphingolipid that regulates a variety of cellular processes. To facilitate the study of ceramide localization and its interaction with cellular proteins, we have developed a novel antibody against ceramide.
Kannan Krishnamurthy +2 more
doaj +1 more source
Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress
International Journal of Oral Science, 2021 C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our
Wen Chen +11 more
doaj +1 more source
Hepatology, EarlyView., 2022 NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger +7 more
wiley +1 more source
Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties [PDF]
, 2015 This work was supported by National Institute of Mental Health grants: P30 MH075673-06 to BSS, CR, NJH and JCM; R01 MH096636 and R01 MH077542 to NJH (http://projectreporter.nih.gov/reporter.cfm); and The Johns Hopkins Brain Science Institute to BSS ...
Justin C. McArthur (66539) +48 more
core +2 more sources
Advances in determining signaling mechanisms of ceramide and role in disease
Journal of Lipid Research, 2019 Ceramide is a critical bioactive lipid involved in diverse cellular processes. It has been proposed to regulate cellular processes by influencing membrane properties and by directly interacting with effector proteins.
Jeffrey L. Stith +2 more
doaj +1 more source
Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes
Journal of Lipid Research, 2018 We reported that amyloid β peptide (Aβ42) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes.
Ji-Na Kong +13 more
doaj +1 more source
Ceramide in the prostate [PDF]
Cancer Biology & Therapy, 2013 The nomenclature for the serine/threonine protein phosphatases was established by Professor Sir Philip Cohen over 30 years ago. (1) At that time protein phosphatase 1 was known to have two small inhibitory proteins (I-1 and I-2) and be regulated by sub-cellular location whereas no protein inhibitor had yet been discovered for the related multi-subunit ...
openaire +2 more sources
C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia. [PDF]
PLoS ONE, 2013 Ceramide is a sphingolipid metabolite that induces cancer cell death. When C6-ceramide is encapsulated in a nanoliposome bilayer formulation, cell death is selectively induced in tumor models. However, the mechanism underlying this selectivity is unknown.
Lindsay K Ryland +16 more
doaj +1 more source
Ceramide Kinase and Ceramide‐1‐Phosphate
, 2007 It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK).
Dayanjan S, Wijesinghe +3 more
openaire +3 more sources