Results 21 to 30 of about 72,817 (297)

Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress

International Journal of Oral Science, 2021
C18 ceramide plays an important role in the occurrence and development of oral squamous cell carcinoma. However, the function of ceramide synthase 1, a key enzyme in C18 ceramide synthesis, in oral squamous cell carcinoma is still unclear. The aim of our
Wen Chen, Chenzhou Wu, Yafei Chen, Yuhao Guo, Ling Qiu, Zhe Liu, Haibin Sun, Siyu Chen, Zijian An, Zhuoyuan Zhang, Yi Li, Longjiang Li   +11 more
doaj   +1 more source

Sphingolipid and ceramide homeostasis : potential therapeutic targets [PDF]

, 2012
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction.
Smith, Terry, Simon A. Young, Denny, Paul, Young, Simon, Denny, Paul W., Mina, J.G., Mina, John, Denny, P.W., Smith, Terry K., Mina, John G., John G. Mina, Young, S.A., Smith, T.K., Paul W. Denny, Young, Simon A., Terry K. Smith   +15 more
core   +1 more source

Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway

Journal of Pharmacological Sciences, 2010
.: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromatography using
Eiko Tada, Kaori Toyomura, Hiroyuki Nakamura, Hirotsune Sasaki, Takeshi Saito, Masayuki Kaneko, Yasunobu Okuma, Toshihiko Murayama   +7 more
doaj   +1 more source

Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes

Journal of Lipid Research, 2018
We reported that amyloid β peptide (Aβ42) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes.
Ji-Na Kong, Zhihui Zhu, Yutaka Itokazu, Guanghu Wang, Michael B. Dinkins, Liansheng Zhong, Hsuan-Pei Lin, Ahmed Elsherbini, Silvia Leanhart, Xue Jiang, Haiyan Qin, Wenbo Zhi, Stefka D. Spassieva, Erhard Bieberich   +13 more
doaj   +1 more source

Advances in determining signaling mechanisms of ceramide and role in disease

Journal of Lipid Research, 2019
Ceramide is a critical bioactive lipid involved in diverse cellular processes. It has been proposed to regulate cellular processes by influencing membrane properties and by directly interacting with effector proteins.
Jeffrey L. Stith, Fabiola N. Velazquez, Lina M. Obeid   +2 more
doaj   +1 more source

Ceramide in the prostate [PDF]

Cancer Biology & Therapy, 2013
The nomenclature for the serine/threonine protein phosphatases was established by Professor Sir Philip Cohen over 30 years ago. (1) At that time protein phosphatase 1 was known to have two small inhibitory proteins (I-1 and I-2) and be regulated by sub-cellular location whereas no protein inhibitor had yet been discovered for the related multi-subunit ...
openaire   +2 more sources

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties [PDF]

, 2015
This work was supported by National Institute of Mental Health grants: P30 MH075673-06 to BSS, CR, NJH and JCM; R01 MH096636 and R01 MH077542 to NJH (http://projectreporter.nih.gov/reporter.​cfm); and The Johns Hopkins Brain Science Institute to BSS ...
Justin C. McArthur (66539), Bandaru, Veera Venkata Ratnam, Graeme W. Rogers (744791), Yoo, Seung-Wan, Seung-Wan Yoo (744790), McArthur, Justin C., Justin C McArthur, Veera Venkata Ratnam Bandaru (193990), Haughey, Norman J., Marigo Stathis, Graeme W Rogers, Figuera-Losada, Mariana, Veera Venkata Ratnam Bandaru, Stathis, Marigo, Norman J Haughey, Slusher, Barbara S., Barbara S Slusher, Barbara S. Slusher (634276), Joelle M Dorskind, Nicholas J Westwood, Seung-Wan Yoo, Norman J. Haughey (193998), Mariana Figuera-Losada (744786), Marigo Stathis (744787), Camilo Rojas (744792), Ajit G. Thomas (744789), Westwood, Nicholas James, Rojas, Camilo, Nicholas J. Westwood (254891), Thomas, Ajit G., Rogers, Graeme Wayne, Mariana Figuera-Losada, Joelle M. Dorskind (744788), Ajit G Thomas, Dorskind, Joelle M., Camilo Rojas   +35 more
core   +2 more sources

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia. [PDF]

PLoS ONE, 2013
Ceramide is a sphingolipid metabolite that induces cancer cell death. When C6-ceramide is encapsulated in a nanoliposome bilayer formulation, cell death is selectively induced in tumor models. However, the mechanism underlying this selectivity is unknown.
Lindsay K Ryland, Ushma A Doshi, Sriram S Shanmugavelandy, Todd E Fox, Cesar Aliaga, Kathleen Broeg, Kendall Thomas Baab, Megan Young, Osman Khan, Jeremy K Haakenson, Nancy Ruth Jarbadan, Jason Liao, Hong-Gang Wang, David J Feith, Thomas P Loughran, Xin Liu, Mark Kester   +16 more
doaj   +1 more source

Ceramide Kinase and Ceramide‐1‐Phosphate

, 2007
It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK).
Dayanjan S, Wijesinghe, Nadia F, Lamour, Antonio, Gomez-Munoz, Charles E, Chalfant   +3 more
openaire   +3 more sources

Turnover of endogenous ceramide in cultured normal and Farber fibroblasts

Journal of Lipid Research, 1997
De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine.
G van Echten-Deckert, A Klein, T Linke, T Heinemann, J Weisgerber, K Sandhoff   +5 more
doaj   +1 more source