Results 41 to 50 of about 602,436 (300)

Lysosphingolipids in ceramide-deficient skin lipid models

Journal of Lipid Research
Ceramides are key components of the skin's permeability barrier. In atopic dermatitis, pathological hydrolysis of ceramide precursors - glucosylceramides and sphingomyelin - into lysosphingolipids, specifically glucosylsphingosine (GS) and sphingosine ...
Georgios Paraskevopoulos, Lukáš Opálka, Andrej Kováčik, Anna Paraskevopoulou, Eleni Panoutsopoulou, Irene Sagrafena, Petra Pullmannová, Robert Čáp, Kateřina Vávrová   +8 more
doaj   +1 more source

Revealing the Correlation between Altered Skin Lipids Composition and Skin Disorders

Cosmetics, 2021
Human skin layers serve as a barrier between the body and the environment, by preventing water loss and blocking the entry of chemicals, allergens, and microbes.
Katerina Drakou, Andrea Tsianni, Faye Vrani, Valia Kefala, Efstathios Rallis   +4 more
doaj   +1 more source

Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]

, 2020
Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M, Cau, Laura, Dupont, Christopher L, Gallo, Richard L, Horswill, Alexander R, Hovnanian, Alain, Kaul, Drishti, Khalil, Shadi, Sanford, James A, Wang, Yichen, Williams, Michael R, Zaramela, Livia S, Zengler, Karsten   +12 more
core  

Localization of dexamethasone within dendritic core-multishell (CMS) nanoparticles and skin penetration properties studied by multi-frequency electron paramagnetic resonance (EPR) spectroscopy [PDF]

, 2016
The skin and especially the stratum corneum (SC) act as a barrier and protect epidermal cells and thus the whole body against xenobiotica of the external environment. Topical skin treatment requires an efficient drug delivery system (DDS).
Anske, M., Bittl, R., Fleige, E., Haag, R., Lohan, S.B., Meinke, M.C., Saeidpour, S., Teutloff, C., Unbehauen, M.   +8 more
core   +1 more source

Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles. [PDF]

, 2019
ObjectiveAlmonds are a rich source of fatty acids and antioxidants, and their supplementation is known to significantly modulate serum lipids. The effects of almond on the skin's lipid barrier and the appearance of wrinkles have not yet been elucidated ...
Burney, Waqas A, Chodur, Gwen M, Foolad, Negar, Newman, John W, Rybak, Iryna, Sivamani, Raja K, Steinberg, Francene M, Vaughn, Alexandra R   +7 more
core   +1 more source

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial. [PDF]

, 2020
BACKGROUND: Skin barrier dysfunction precedes eczema development. We tested whether daily use of emollient in the first year could prevent eczema in high-risk children. METHODS: We did a multicentre, pragmatic, parallel-group, randomised controlled trial
BEEP study team, Boyle, RJ, Bradshaw, LE, Brown, SJ, Chalmers, JR, Cork, MJ, Davies-Jones, S, Flohr, C, Haines, RH, Jay, N, Kelleher, MM, Lawton, S, Mitchell, EJ, Montgomery, AA, Perkin, MR, Ridd, MJ, Sach, TH, Simpson, EL, Swinden, R, Tarr, S, Thomas, KS, Williams, HC   +21 more
core   +8 more sources

Impact of Age and Body Site on Adult Female Skin Surface pH [PDF]

, 2012
Background: pH is known as an important parameter in epidermal barrier function and homeostasis. Aim: The impact of age and body site on skin surface pH (pH(SS)) of women was evaluated in vivo.
Barbara Behm, Barland CO, Behne MJ, Behne MJ, Braun-Falco O, Choi EH, Dikstein S, Elias PM, Fluhr JW, Fluhr JW, Ghadially R, Ghadially R, Giusti F, Hachem JP, Hans Christian Korting, Hoeger PH, Kim EJ, Kocinkova AS, Korting HC, Korting HC, Kürner JM, Lambers H, Liebsch G, Mauro T, Michael Landthaler, Philipp Babilas, Posch HE, Robert Johannes Meier, Schmid-Wendtner MH, Schmuth M, Schreml S, Schreml S, Seyfarth F, Stephan Schreml, Takagi Y, Veronika Zeller, Wilhelm KP, Ye J, Yosipovitch G, Yosipovitch G, Zlotogorski A   +40 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

N-alkylamides : from plant to brain [PDF]

, 2014
Background: Plant N-alkylamides (NAAs) are bio-active compounds with a broad functional spectrum. In order to reach their pharmacodynamic targets, they have to overcome several barriers of the body in the absorption phase.
De Spiegeleer, Bart, Joshi, Tanmayee, Taevernier, Lien, Tatke, Pratima, Verbeke, Frederick, Veryser, Lieselotte, Wynendaele, Evelien   +6 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source