Results 1 to 10 of about 41,371 (294)
Stem Cell Reports, 2017 Summary: Ceramides and their metabolites are important for the homeostasis of the epidermis, but much remains unknown about the roles of specific pathways of ceramide metabolism in skin biology.
Chih-Li Lin +14 more
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Lamellar and inverse micellar structures of skin lipids: Effect of templating [PDF]
, 2014 The outermost layer of skin, the stratum corneum (SC), comprises rigid corneocytes in a layered lipid matrix. Using atomistic simulations we find that the equilibrium phase of the SC lipids is inverse micellar.
Das, Chinmay +2 more
core +1 more source
Endoplasmic Reticulum Export of GPI-Anchored Proteins [PDF]
, 2019 Protein export from the endoplasmic reticulum (ER) is an essential process in all eukaryotes driven by the cytosolic coat complex COPII, which forms vesicles at ER exit sites for transport of correctly assembled secretory cargo to the Golgi apparatus ...
López Martín, Sergio +3 more
core +1 more source
JACC: Basic to Translational Science, 2018 Summary: We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery,
Leonardo P. de Carvalho, MD, PhD +17 more
doaj +1 more source
Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy
European Journal of Cell Biology, 2023 Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer.
Javad Alizadeh +11 more
doaj +1 more source
Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
core +1 more source
Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study. [PDF]
, 2019 Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease.
Armirotti, Andrea +9 more
core +1 more source
Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
, 2020 A comprehensive characterization of the lipidome from limited starting material remains very challenging. Here we report a high-sensitivity lipidomics workflow based on nanoflow liquid chromatography and trapped ion mobility spectrometry (TIMS).
Barsch, A. +8 more
core +1 more source
C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. [PDF]
PLoS ONE, 2013 Specific ceramides are key regulators of cell fate, and extensive studies aimed to develop therapies based on ceramide-induced cell death. However, the mechanisms regulating ceramide cytotoxicity are not yet fully elucidated.
Andreia Pacheco +6 more
doaj +1 more source
Gene Expression Signature in Adipose Tissue of Acromegaly Patients. [PDF]
, 2014 To study the effect of chronic excess growth hormone on adipose tissue, we performed RNA sequencing in adipose tissue biopsies from patients with acromegaly (n = 7) or non-functioning pituitary adenomas (n = 11).
Barkan, Ariel L +5 more
core +6 more sources