Results 11 to 20 of about 31,716 (293)

Blood-brain barrier permeability analysis of plant ceramides.

PLoS ONE, 2020
Ceramides, a type of sphingolipid, are cell membrane components and lipid mediators that modulate a variety of cell functions. In plants, ceramides are mostly present in a glucosylated glucosylceramide (GlcCer) form.
Koichi Eguchi, Daisuke Mikami, Hui Sun, Takuya Tsumita, Kaori Takahashi, Katsuyuki Mukai, Kohei Yuyama, Yasuyuki Igarashi   +7 more
doaj   +2 more sources

The ART of Lowering Ceramides [PDF]

Cell Metabolism, 2015
Ceramides are lipid metabolites implicated in the metabolic dysregulation that accompanies dyslipidaemia and obesity. Using a genetic mouse model to acutely degrade ceramides in adipose tissue or the liver (i.e., by conditionally expressing acid ...
Summers, Scott A.
core   +4 more sources

Ceramides: focus on obesity [PDF]

Ожирение и метаболизм, 2020
It is generally known that obesity increases the risk of developing cardiovascular disease. A pathological increase in the mass of adipose tissue leads to a violation of the control of lipid accumulation at the molecular level, abnormal lipid metabolism ...
Yulia A. Dyleva, Olga V. Gruzdeva, Ekaterina V. Belik   +2 more
doaj   +2 more sources

Ceramides and Ceramide Scores: Clinical Applications for Cardiometabolic Risk Stratification

Frontiers in Endocrinology, 2020
Ceramides are bioactive lipids that have an important role in many cellular functions such as apoptosis and inflammation. During the past decade emerging clinical data have shown that ceramides are not only of great biochemical interest but may also have
Mika Hilvo, Vlad C. Vasile, Leslie J. Donato, Reini Hurme, Reijo Laaksonen, Reijo Laaksonen   +5 more
doaj   +2 more sources

Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy

European Journal of Cell Biology, 2023
Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer.
Javad Alizadeh, Simone C. da Silva Rosa, Xiaohui Weng, Joadi Jacobs, Shahrokh Lorzadeh, Amir Ravandi, Rui Vitorino, Stevan Pecic, Aleksandra Zivkovic, Holger Stark, Shahla Shojaei, Saeid Ghavami   +11 more
doaj   +3 more sources

The Role of Ceramides in Metabolic and Cardiovascular Diseases

Journal of Cardiovascular Development and Disease
Ceramides are bioactive sphingolipids increasingly recognized as mediators of cardiometabolic disease and residual cardiovascular risk. Accumulating evidence from experimental and clinical studies indicates that specific ceramide species contribute to ...
Manuel Gonzalez-Plascencia, Idalia Garza-Veloz, Virginia Flores-Morales, Margarita L. Martinez-Fierro   +3 more
doaj   +2 more sources

Serum ceramides in early pregnancy as predictors of gestational diabetes [PDF]

, 2023
Ceramides contribute to the development of type 2 diabetes but it is uncertain whether they predict gestational diabetes (GDM). In this multicentre case–control study including 1040 women with GDM and 958 non-diabetic controls, early pregnancy (mean 10.7
Laivuori, Hannele, Pouta, Anneli, Antti Jylhä, Mustaniemi, Sanna, Laaksonen, Reijo, Hanna Öhman, Tuija Männistö, Kajantie, Eero, Sanna Mustaniemi, Marja Vääräsmäki, The FinnGeDi Study Group, Elina Keikkala, Ohman, Hanna, Anneli Pouta, Eero Kajantie, Eriksson, Johan G., Gissler, Mika, Reijo Laaksonen, Risto Kaaja, Vääräsmäki, Marja, Nurhonen, Markku, Johan G. Eriksson, Laure Morin-Papunen, Morin-Papunen, Laure, Markku Nurhonen, Kaaja, Risto, Männistö, Tuija, Jylhä, Antti, Keikkala, Elina, Hannele Laivuori, Mika Gissler, Kajantie, Eero Olavi   +31 more
core   +1 more source

Many Ceramides [PDF]

Journal of Biological Chemistry, 2011
Intensive research over the past 2 decades has implicated ceramide in the regulation of several cell responses. However, emerging evidence points to dramatic complexities in ceramide metabolism and structure that defy the prevailing unifying hypothesis on ceramide function that is based on the understanding of ceramide as a single entity.
Yusuf A, Hannun, Lina M, Obeid
openaire   +2 more sources

Discovery of Dihydroxy-Ketone-Type Protein-Bound Ceramides as the Dominant Type in Human Stratum Corneum. [PDF]

FASEB J
Protein‐bound ceramides are a specialized subclass of ceramides that are essential for skin barrier function, and their defective formation leads to severe skin disorder ichthyosis. Despite their biological importance, the precise molecular structures of
Kojima A, Sugiyama T, Ito Y, Otsuka K, Ohno Y, Kihara A.   +5 more
europepmc   +2 more sources

Ceramide and ceramide 1-phosphate in health and disease [PDF]

Lipids in Health and Disease, 2010
AbstractSphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction of apoptosis.
Gómez-Muñoz Antonio, Trueba Miguel, Ouro Alberto, Gangoiti Patricia, Arana Lide   +4 more
openaire   +4 more sources