Results 21 to 30 of about 31,716 (293)

Plasma ceramides are associated with MRI-based liver fat content but not with noninvasive scores of liver fibrosis in patients with type 2 diabetes

Cardiovascular Diabetology, 2023
Background There is growing evidence that ceramides play a significant role in the onset and progression of non-alcoholic fatty liver disease (NAFLD), a highly prevalent condition in patients with type 2 diabetes associated with hepatic and ...
Damien Denimal, Sarah Béland-Bonenfant, Jean-Paul Pais-de-Barros, Alexia Rouland, Benjamin Bouillet, Laurence Duvillard, Bruno Vergès, Jean-Michel Petit   +7 more
doaj   +1 more source

Targeting Ceramides and Adiponectin Receptors in the Islet of Langerhans for Treating Diabetes

Molecules, 2022
Ceramides belong to the sphingolipid family and represent the central hub of the sphingolipid network. In obesity, oversupply of saturated fatty acids including palmitate raises ceramide levels which can be detrimental to cells.
Wen-hong Li
doaj   +1 more source

Ceramides: a new player in the inflammation-insulin resistance paradigm? [PDF]

, 2009
No abstract ...
Sattar, N., Gill, J.M.R.
core   +1 more source

Identification and quantitation of free ceramides in human platelets

Journal of Lipid Research, 1972
Free ceramides were isolated from human platelets. Their structures were unequivocally determined by gas–liquid chromatography–mass spectrometry of the trimethylsilyl ether derivatives.
William Krivit, Sven Hammarström
doaj   +1 more source

Ceramides and phospholipids in plasma extracellular vesicles are associated with high risk of major cardiovascular events after carotid endarterectomy

Scientific Reports, 2022
Ceramides and phosphatidylcholines (PCs) are bioactive lipids and lipid bilayer membrane components. Distinct ceramides/PCs (ratios) predict cardiovascular outcome in patients with coronary artery disease.
Nathalie Timmerman, Farahnaz Waissi, Mirthe Dekker, Gert J. de Borst, Joelle van Bennekom, Robbert J. de Winter, Mika Hilvo, Antti Jylhä, Gerard Pasterkamp, Dominique P. V. de Kleijn, Reijo Laaksonen   +10 more
doaj   +1 more source

Ceramides as Novel Disease Biomarkers

, 2022
S.20-32Ceramides are sphingolipids and integral components of the eukaryotic cell membrane. Apart from providing structural integrity, ceramides have also been shown to act as second messengers in cell signaling processes.
Schiffmann, S., Parnham, M.J., Geisslinger, G., Kurz, J.   +3 more
core   +1 more source

Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases

Journal of Lipid Research, 2022
Ceramides are essential lipids for skin permeability barrier function, and a wide variety of ceramide species exist in the stratum corneum (SC). Although ceramides with long-chain bases (LCBs) of various lengths have been identified in the human SC, a ...
Madoka Suzuki, Yusuke Ohno, Akio Kihara
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Ceramide in the prostate [PDF]

Cancer Biology & Therapy, 2013
The nomenclature for the serine/threonine protein phosphatases was established by Professor Sir Philip Cohen over 30 years ago. (1) At that time protein phosphatase 1 was known to have two small inhibitory proteins (I-1 and I-2) and be regulated by sub-cellular location whereas no protein inhibitor had yet been discovered for the related multi-subunit ...
openaire   +2 more sources

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source