Results 31 to 40 of about 29,498 (282)

Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases

Journal of Lipid Research, 2022
Ceramides are essential lipids for skin permeability barrier function, and a wide variety of ceramide species exist in the stratum corneum (SC). Although ceramides with long-chain bases (LCBs) of various lengths have been identified in the human SC, a ...
Madoka Suzuki, Yusuke Ohno, Akio Kihara
doaj   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Roles of Ceramides in Non-Alcoholic Fatty Liver Disease [PDF]

, 2021
International audienceNon-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis.
Ferré, Pascal, Fabienne Foufelle, Foufelle, Fabienne, Floriane Lachkar, Hajduch, Eric, Lachkar, Floriane, Eric Hajduch, Pascal Ferré   +7 more
core   +1 more source

Ceramide Kinase and Ceramide‐1‐Phosphate

, 2007
It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK).
Dayanjan S, Wijesinghe, Nadia F, Lamour, Antonio, Gomez-Munoz, Charles E, Chalfant   +3 more
openaire   +3 more sources

Fuse your mitochondria, lose appetite: an anorexic, anti‐obesity sphingolipid

EMBO Molecular Medicine, 2021
Aberrant production of ceramides, the precursors of complex sphingolipids, is a hallmark of obesity and strongly linked to metabolic dysfunction (Meikle and Summers 2017).
Carolin Muley, Alexander Bartelt
doaj   +1 more source

Lipidomic Analysis to Assess the Correlation between Ceramides, Stress Hyperglycemia, and HbA1c in Acute Myocardial Infarction

Molecules, 2023
Ceramides have been associated with cardiometabolic disease (e.g., acute myocardial infarction (AMI) and type 2 diabetes (T2D)) and adverse outcomes. Acute admission hyperglycemia (AH) is a transient glucose alteration in response to stress.
Melania Gaggini, Elena Michelucci, Rudina Ndreu, Silvia Rocchiccioli, Kyriazoula Chatzianagnostou, Sergio Berti, Cristina Vassalle   +6 more
doaj   +1 more source

Ceramides: A potential therapeutic target in pulmonary emphysema [PDF]

, 2013
Background: The aim of this manuscript was to characterize airway ceramide profiles in a rodent model of elastase-induced emphysema and to examine the effect of pharmacological intervention directed towards ceramide metabolism.Methods: Adult mice were ...
Reiss, I.K.M. (Irwin), Johan C de Jongste, Reiss, Irwin, Jongste, J.C. (Johan) de, Jeroen Tibboel, Irwin Reiss, Jongste, Johan, Post, M.R. (Martin), Verhoef-Post, M, Martin Post, Tibboel, Jeroen   +10 more
core   +4 more sources

Novel ceramides recovered from Porphyromonas gingivalis: relationship to adult periodontitis

Journal of Lipid Research, 1998
The primary purpose of this study was to characterize the major structural features of ceramides recovered from Porphyromonas gingivalis, a suspected periodontal pathogen. Complex lipids extracted from P.
Frank C. Nichols
doaj   +1 more source

Analysis and quantitation of free ceramide containing nonhydroxy and 2-hydroxy fatty acids, and phytosphingosine by high-performance liquid chromatography.

Journal of Lipid Research, 1979
Reaction of ceramides containing nonhydroxy fatty acids with benzoyl chloride in pyridine at 70 degrees C for 1 hr resulted in N-benzoylation to form N,N-acyl,benzoyl derivatives; O-benzoylation also occurred.
M Iwamori, C Costello, H W Moser
doaj   +1 more source