Results 51 to 60 of about 41,371 (294)
Mammalian ceramide synthases [PDF]
IUBMB Life, 2010 AbstractIn mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and ...
Michal, Levy, Anthony H, Futerman
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Lipid changes within the epidermis of living skin equivalents observed across a time-course by MALDI-MS imaging and profiling [PDF]
, 2015 © 2015 Mitchell et al. Abstract Background: Mass spectrometry imaging (MSI) is a powerful tool for the study of intact tissue sections. Here, its application to the study of the distribution of lipids in sections of reconstructed living skin equivalents ...
Clench, Malcolm +4 more
core +2 more sources
Ceramide Kinase and Ceramide‐1‐Phosphate
, 2007 It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK).
Dayanjan S, Wijesinghe +3 more
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Journal of Lipid Research, 1980 Chicken egg yolk phospholipids were subjected to mild alkaline hydrolysis. The resulting alkali-stable phospholipids were characterized by chemical chromatographic, and enzymatic methods.
U H Do, S Ramachandran
doaj +1 more source
Gastroenterologìa, 2020 Background. Ceramides are the fats of the sphingolipid family that are involved in the development of insulin resistance, non-alcoholic fatty liver disease, and type 2 diabetes.
L.L. Pavlovskyi
doaj +1 more source
Untargeted Lipidomic Analysis to Broadly Characterize the Effects of Pathogenic and Non-Pathogenic Staphylococci on Mammalian Lipids [PDF]
, 2018 Modification of the host lipidome via secreted enzymes is an integral, but often overlooked aspect of bacterial pathogenesis. In the current era of prevalent antibiotic resistance, knowledge regarding critical host pathogen lipid interactions has the ...
Baker, Paul RS +5 more
core +4 more sources
A method for the quantitative determination of neutral glycosphingolipids in urine sediment
Journal of Lipid Research, 1970 A method is described for the isolation and quantitation of six neutral glycosyl ceramides from human urinary sediment. Total lipids were extracted from sediments of 24-hr urine collections, and the glycosyl ceramides were isolated by silicic acid column
R.J. Desnick, C.C. Sweeley, W. Krivit
doaj +1 more source
Detergent-Resistant, Ceramide-Enriched Domains in Sphingomyelin/Ceramide Bilayers [PDF]
Biophysical Journal, 2006 When cell membranes are treated with Triton X-100 or other detergents at 4 degrees C, a nonsolubilized fraction can often be recovered, the "detergent-resistant membranes", that is not found when detergent treatment takes place at 37 degrees C. Detergent-resistant membranes may be related in some cases to membrane "rafts".
Sot, Jesus +3 more
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Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis [PDF]
Journal of Lipid Research, 2007 Ceramide kinase (CERK) is a critical mediator of eicosanoid synthesis, and its product, ceramide-1-phosphate (C1P), is required for the production of prostaglandins in response to several inflammatory agonists. In this study, mass spectrometry analysis disclosed that the main forms of C1P in cells were C(16:0) C1P and C(18:0) C1P, suggesting that CERK ...
Nadia F. Lamour +8 more
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source