Results 71 to 80 of about 31,716 (293)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

CERAMIDES AND SKIN FUNCTION

, 2020
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier property of the epidermis.
Parra Juez, José Luis, Coderch Negra, M. Luisa, López Serrano, Olga, Maza, Alfons de la   +3 more
core  

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Ceramides in the Skin Lipid Membranes: Length Matters

, 2016
Ceramides are essential constituents of the skin barrier that allow humans to live on dry land. Reduced levels of ceramides have been associated with skin diseases, e.g., atopic dermatitis. However, the structural requirements and mechanisms of action of
Jarmila Zbytovská (1869982), Pavel Berka (1869973), Karel Palát (1755343), Joke Bouwstra (1869976), Barbora Školová (1755349), Barbora Janůšová (1869964), Kateřina Vávrová (1233546), Jaroslav Roh (1233549), Alexandr Hrabálek (1869970), Petr Slepička (1869979), Gert Gooris (1869967)   +10 more
core   +1 more source

Human Epidermal Glucosylceramides are Major Precursors of Stratum Corneum Ceramides [PDF]

, 2002
Ceramides are the major component of the stratum corneum, accounting for 30%-40% of stratum corneum lipids by weight, and are composed of at least seven molecular groups (designated ceramides 1–7). Stratum corneum ceramides, together with cholesterol and
Hamanaka, Sumiko, Nishio, Hiroyuki, Otsuka, Fujio, Mariko Hara, Hiroyuki Nishio, Hara, Mariko, Yoshikazu Uchida, Fujio Otsuka, Akemi Suzuki, Suzuki, Akemi, Sumiko Hamanaka, Uchida, Yoshikazu   +11 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

EO and O ceramides, TEWL in atopic dermatitis stratum corneum

, 2019
The quantitative amounts of all bound O ceramides and EO ceramides in stratum corneum samples from healthy volunteers and atopic dermatitis patient. Data are quantified by LC/MS and corrected for the SQ-value (amount on tapes used to acquire the sample).
Boiten, W (via Mendeley Data)
core   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology

Nature Communications, 2022
Among lipid classes, ceramides are linked to impaired cardiometabolic health. Here the authors report the association of specific ceramides and dihydroceramides on the risk of developing type 2 diabetes and or cardiovascular disease in a prospective ...
C. Wittenbecher, R. Cuadrat, L. Johnston, F. Eichelmann, S. Jäger, O. Kuxhaus, M. Prada, F. Del Greco M., A. A. Hicks, P. Hoffman, J. Krumsiek, F. B. Hu, M. B. Schulze   +12 more
doaj   +1 more source

Azido-Ceramides, a Tool to Analyse SARS-CoV-2 Replication and Inhibition—SARS-CoV-2 Is Inhibited by Ceramides

, 2023
Recently, we have shown that C6-ceramides efficiently suppress viral replication by trapping the virus in lysosomes. Here, we use antiviral assays to evaluate a synthetic ceramide derivative α-NH2-ω-N3-C6-ceramide (AKS461) and to confirm the ...
Linda Stelz, Schlegel, Jan, Sauer, Markus, Jan Schlegel, Viktoria Diesendorf, Fink, Julian, Stelz, Linda, Seibel, Jürgen, Kersting, Louise, Markus Sauer, Geiger, Nina, Bodem, Jochen, Nina Geiger, Diesendorf, Viktoria, Schneider-Schaulies, Sibylle, Daniela Brenner, Jürgen Seibel, Louise Kersting, Sibylle Schneider-Schaulies, Julian Fink, Brenner, Daniela, Jochen Bodem   +21 more
core   +1 more source