Results 71 to 80 of about 29,498 (282)

Imaging‐Guided Live Single‐Cell Lipid Profiling of Leader and Follower Cells During Collective Migration of Triple‐Negative Breast Cancer Cells

Advanced Science, EarlyView.
Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang, Judit González Riera, Mai Nguyen, Jeremy Broekhuis, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier   +6 more
wiley   +1 more source

Progress in the analysis of stratum corneum ceramides [PDF]

, 2004
The stratum corneum with its unique structure of corneocytes and intercellular lipid lamellae enables a protection of human and other mammalian skin against transepidermal water loss and harmful substances from the environment.
Neubert, Reinhard HH, Raith, Klaus, Farwanah, Hany, Wartewig, Siegfried   +3 more
core   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides [PDF]

, 2019
Ceramides are central intermediates of sphingolipid metabolism that also function as potent messengers in stress signaling and apoptosis. Progress in understanding how ceramides execute their biological roles is hampered by a lack of methods to ...
Sergei Korneev, Ben Williams, Schwille, Petra, Matthijs Kol, Henry Toombs-Ruane, Korneev, S., Dirk Trauner, Kol, Matthijs, Toombs-Ruane, Henry, Korneev, Sergei, Trauner, Dirk, Williams, B., Holthuis, J., James A Frank, Henri G Franquelim, Franquelim, H., Trauner, D., Christian Schroeer, Schroeer, Christian, Toombs-Ruane, H., Holthuis, Joost C. M., Frank, J., Franquelim, Henri G., Petra Schwille, Frank, James A., Schwille, P., Schroeer, C., Williams, Ben, Kol, M., Joost CM Holthuis   +29 more
core   +2 more sources

Extraction and Quantification of Sphingolipids from Hemiptera Insects by Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry

Bio-Protocol, 2021
Sphingolipids are major structural components of endomembranes and have also been described as an intracellular second messenger involved in various biological functions in all eukaryotes and a few prokaryotes.
Ni Wang, Xiao-Xiao Shi, Chao Zhang, Wen-Wu Zhou, Zeng-Rong Zhu   +4 more
doaj   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology

Nature Communications, 2022
Among lipid classes, ceramides are linked to impaired cardiometabolic health. Here the authors report the association of specific ceramides and dihydroceramides on the risk of developing type 2 diabetes and or cardiovascular disease in a prospective ...
C. Wittenbecher, R. Cuadrat, L. Johnston, F. Eichelmann, S. Jäger, O. Kuxhaus, M. Prada, F. Del Greco M., A. A. Hicks, P. Hoffman, J. Krumsiek, F. B. Hu, M. B. Schulze   +12 more
doaj   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Novel ceramides and a new glucoceramide from the roots of Incarvillea arguta [PDF]

, 2004
Novel ceramides, rel-(3S,4S,5S)-3-[(2R)-2-hydroxycosanoylsimilar tohexacosanoylamino]-4-hydroxy-5-[(4Z)-tetradecane- 4-ene]-2,3,4,5-tetrahydrofuran (1a-g), and a new glucoceramide, 1-O-beta-D-glucopyranosyl-(2S,3S,4R,8E)-2-[(2R)-2-hydroxytetracosanoylam ...
Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, POB 416, Chengdu 610041, Peoples R China., Luo, YG, Yi, JH, Li, BG, Zhang, GL   +4 more
core  

Ceramide signaling in apoptosis [PDF]

British Medical Bulletin, 1997
The sphingomyelin pathway is a ubiquitous, evolutionarily conserved signaling system initiated by hydrolysis of the plasma membrane phospholipid sphingomyelin to generate ceramide. Ceramide acts as a second messenger in activating the apoptotic cascade. Diverse cytokine receptors and environmental stresses utilize ceramide to signal apoptosis.
A, Haimovitz-Friedman, R N, Kolesnick, Z, Fuks   +2 more
openaire   +2 more sources