Results 61 to 70 of about 29,498 (282)

C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. [PDF]

PLoS ONE, 2013
Specific ceramides are key regulators of cell fate, and extensive studies aimed to develop therapies based on ceramide-induced cell death. However, the mechanisms regulating ceramide cytotoxicity are not yet fully elucidated.
Andreia Pacheco, Flávio Azevedo, António Rego, Júlia Santos, Susana R Chaves, Manuela Côrte-Real, Maria João Sousa   +6 more
doaj   +1 more source

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids

Journal of Lipid Research, 2020
The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has ...
Iris D. Zelnik, Giora Volpert, Leena E. Viiri, Dimple Kauhanen, Tamar Arazi, Katriina Aalto-Setälä, Reijo Laaksonen, Anthony H. Futerman   +7 more
doaj   +1 more source

Intracellular trafficking of ceramide by ceramide transfer protein

Proceedings of the Japan Academy, Series B, 2010
The transport and sorting of lipids are fundamental to membrane biogenesis. In the synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the endoplasmic reticulum (ER), and transported from the ER to the trans Golgi regions, where it is converted to sphingomyelin.
openaire   +3 more sources

Lonicera japonica‐Derived Nanovesicles Ameliorate Acute Lung Injury by Suppressing Neutrophil Extracellular Traps Formation in Mice

Advanced Healthcare Materials, EarlyView.
(A) Isolation and purification of LDNVs. (B) Establishment of the ALI model and LDNVs delivery. (C) Therapeutic mechanisms of LDNVs in treating ALI. This scheme figure was drawn by Figdraw, ID: IUIIO21222. ABSTRACT Acute lung injury (ALI) is a lethal respiratory disease.
Xi Lin, Jian Lin, Yezi Zhang, Xinyan Zhang, Xinghua Liu, Hongying Cao, Huan Shen, Jianming Liang, Zhenhua Dai, Siyuan Xu, Xingdong Lin   +10 more
wiley   +1 more source

Ceramides improve accuracy in prediction of preclinical atherosclerosis [PDF]

, 2018
Background: Ceramides are known to predict clinical cardiovascular diseases, but their role in prediction of subclinical atherosclerosis is unknown.
Laaksonen, Reijo (6899744), Lehtimäki, Terho, Lehtimäki, Terho (6899747), Lyytikäinen, Leo-Pekka, Lyytikäinen, Leo-Pekka (6899735), Kähönen, Mika, Raitakari, Olli, Mishra, Pashupati, Mishra, Pashupati (6899732), Laaksonen, Reijo, Kähönen, Mika (6899738), Raitakari, Olli (6899741)   +11 more
core   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity

Canadian Journal of Gastroenterology and Hepatology, 2017
Objective. To assess the association between plasma ceramides and hepatic steatosis (HS) in adolescents, independently of obesity. Materials and Methods. Ninety-four adolescents from two previous studies conducted and published by our crew were included.
Jorge Maldonado-Hernández, Gabriela E. Saldaña-Dávila, Mónica I. Piña-Aguero, Benjamín A. Núñez-García, Mardia G. López-Alarcón   +4 more
doaj   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

Ceramide signaling in immunity: a molecular perspective

Lipids in Health and Disease
Ceramides are bioactive lipids that play a crucial role in cellular signaling and structural integrity (Nat Rev Mol Cell Biol 19:175-191, 2018). As members of the sphingolipid family, ceramides consist of a sphingoid base attached to a fatty acid (Annu ...
Himani Thakkar, Vinnyfred Vincent, Bhagirath Chaurasia   +2 more
doaj   +1 more source