Results 61 to 70 of about 31,716 (293)

Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids

Journal of Lipid Research, 2020
The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has ...
Iris D. Zelnik, Giora Volpert, Leena E. Viiri, Dimple Kauhanen, Tamar Arazi, Katriina Aalto-Setälä, Reijo Laaksonen, Anthony H. Futerman   +7 more
doaj   +1 more source

Impact of Albuminuria-Lowering Treatments on Cardiovascular Predictive Ceramides in Diabetes: Post Hoc Analysis of the ROTATE Trials. [PDF]

Diabetes Obes Metab
ABSTRACT Aim Cardiovascular disease (CVD) is the leading cause of mortality in individuals with diabetes. Diabetic kidney disease, closely related to CVD risk, is prevalent in up to 40% of this population. Emerging evidence suggests ceramide lipids as accurate biomarkers for CVD.
Pigsborg K, Kienle SM, Wretlind A, Rotbain Curovic V, Blond MB, Heerspink HJL, Hansen TW, Persson F, Sulek K, Legido-Quigley C, Rossing P.   +10 more
europepmc   +2 more sources

Intracellular trafficking of ceramide by ceramide transfer protein

Proceedings of the Japan Academy, Series B, 2010
The transport and sorting of lipids are fundamental to membrane biogenesis. In the synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the endoplasmic reticulum (ER), and transported from the ER to the trans Golgi regions, where it is converted to sphingomyelin.
openaire   +3 more sources

Ceramide in cerebrovascular diseases

Frontiers in Cellular Neuroscience, 2023
Ceramide, a bioactive sphingolipid, serves as an important second messenger in cell signal transduction. Under stressful conditions, it can be generated from de novo synthesis, sphingomyelin hydrolysis, and/or the salvage pathway. The brain is rich in lipids, and abnormal lipid levels are associated with a variety of brain disorders.
Huiqi Yuan, Bin Zhu, Cao Li, Zhigang Zhao   +3 more
openaire   +3 more sources

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Ceramide signaling in immunity: a molecular perspective

Lipids in Health and Disease
Ceramides are bioactive lipids that play a crucial role in cellular signaling and structural integrity (Nat Rev Mol Cell Biol 19:175-191, 2018). As members of the sphingolipid family, ceramides consist of a sphingoid base attached to a fatty acid (Annu ...
Himani Thakkar, Vinnyfred Vincent, Bhagirath Chaurasia   +2 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity

Canadian Journal of Gastroenterology and Hepatology, 2017
Objective. To assess the association between plasma ceramides and hepatic steatosis (HS) in adolescents, independently of obesity. Materials and Methods. Ninety-four adolescents from two previous studies conducted and published by our crew were included.
Jorge Maldonado-Hernández, Gabriela E. Saldaña-Dávila, Mónica I. Piña-Aguero, Benjamín A. Núñez-García, Mardia G. López-Alarcón   +4 more
doaj   +1 more source

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides [PDF]

, 2019
Ceramides are central intermediates of sphingolipid metabolism that also function as potent messengers in stress signaling and apoptosis. Progress in understanding how ceramides execute their biological roles is hampered by a lack of methods to ...
Sergei Korneev, Ben Williams, Schwille, Petra, Matthijs Kol, Henry Toombs-Ruane, Korneev, S., Dirk Trauner, Kol, Matthijs, Toombs-Ruane, Henry, Korneev, Sergei, Trauner, Dirk, Williams, B., Holthuis, J., James A Frank, Henri G Franquelim, Franquelim, H., Trauner, D., Christian Schroeer, Schroeer, Christian, Toombs-Ruane, H., Holthuis, Joost C. M., Frank, J., Franquelim, Henri G., Petra Schwille, Frank, James A., Schwille, P., Schroeer, C., Williams, Ben, Kol, M., Joost CM Holthuis   +29 more
core   +1 more source