Results 61 to 70 of about 32,676 (287)

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Structural identification of novel bound 1-O-acylceramides in human stratum corneum and murine epidermis using mass spectrometry

Journal of Analytical Science and Technology
The stratum corneum (SC)—the outermost layer of the skin—serves as a barrier that protects the body from environmental stress and prevents transdermal moisture loss.
Bae-Gon Kang, Zhexue Wu, Doohyeon Lee, Yunhi Cho, Taeho Lee, Kwang-Hyeon Liu   +5 more
doaj   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Ceramides: A potential therapeutic target in pulmonary emphysema [PDF]

, 2013
Background: The aim of this manuscript was to characterize airway ceramide profiles in a rodent model of elastase-induced emphysema and to examine the effect of pharmacological intervention directed towards ceramide metabolism.Methods: Adult mice were ...
Reiss, I.K.M. (Irwin), Johan C de Jongste, Reiss, Irwin, Jongste, J.C. (Johan) de, Jeroen Tibboel, Irwin Reiss, Jongste, Johan, Post, M.R. (Martin), Verhoef-Post, M, Martin Post, Tibboel, Jeroen, de Jongste, Johan C, Post, Martin   +12 more
core   +3 more sources

Intracellular trafficking of ceramide by ceramide transfer protein

Proceedings of the Japan Academy, Series B, 2010
The transport and sorting of lipids are fundamental to membrane biogenesis. In the synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the endoplasmic reticulum (ER), and transported from the ER to the trans Golgi regions, where it is converted to sphingomyelin.
openaire   +3 more sources

Challenging a role for ceramide channels and microdomains in apoptosis induction using a bottom-up approach

Scientific Reports
Ceramides are essential but potentially toxic intermediates of sphingolipid metabolism that can act directly on mitochondria to trigger apoptotic cell death, but the underlying mechanism is unclear.
Milena Wessing, Pia Webersinn, Sophie Klaßen, Britta Fiedler, Katia Cosentino, Joost C. M. Holthuis   +5 more
doaj   +1 more source

C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in a sterol-dependent manner. [PDF]

PLoS ONE, 2013
Specific ceramides are key regulators of cell fate, and extensive studies aimed to develop therapies based on ceramide-induced cell death. However, the mechanisms regulating ceramide cytotoxicity are not yet fully elucidated.
Andreia Pacheco, Flávio Azevedo, António Rego, Júlia Santos, Susana R Chaves, Manuela Côrte-Real, Maria João Sousa   +6 more
doaj   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Scalable Synthesis of Human Ultralong Chain Ceramides

, 2015
Ceramides with ultralong chains (≥30 carbons), also known as acylceramides, play a critical role in the survival of mammals on dry land. An efficient and scalable synthesis of four major classes of ultralong human skin ceramides is reported.
Michaela Sochorová (1233543), Andrej Kováčik (1233540), Kateřina Vávrová (1233546), Jiří Kuneš (1233537), Juraj Lenčo (1233534), Lukáš Opálka (1233552), Jaroslav Roh (1233549)   +6 more
core   +1 more source