Results 81 to 90 of about 32,676 (287)

A Single‐Capillary Open Microfluidic Probe for Robust and Versatile Spatial Multi‐Omics Using Ambient Mass Spectrometry Imaging

Advanced Science, EarlyView.
This study reports a knot‐shaped single‐capillary open microfluidic probe (Knot‐probe) for robust and versatile spatial omics, enabling ambient mass spectrometry imaging with high spatial resolution, throughput, and structure‐resolved capability. Knot‐probe mitigates the trade‐off between analytical performance and operational robustness, providing an ...
Xiangyu Zhu, Yunkai Li, Jianing Wang, Chengyi Xie, Lei Guo, Yanyan Chen, Thomas Ka‐Yam Lam, Shao‐Wen Shi, Kun Wang, Baoliang Chen, Zongwei Cai   +10 more
wiley   +1 more source

Ceramides in the Skin Lipid Membranes: Length Matters

, 2016
Ceramides are essential constituents of the skin barrier that allow humans to live on dry land. Reduced levels of ceramides have been associated with skin diseases, e.g., atopic dermatitis. However, the structural requirements and mechanisms of action of
Jarmila Zbytovská (1869982), Pavel Berka (1869973), Karel Palát (1755343), Joke Bouwstra (1869976), Barbora Školová (1755349), Barbora Janůšová (1869964), Kateřina Vávrová (1233546), Jaroslav Roh (1233549), Alexandr Hrabálek (1869970), Petr Slepička (1869979), Gert Gooris (1869967)   +10 more
core   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence. [PDF]

J Cachexia Sarcopenia Muscle
Background Ceramides have garnered considerable attention as pro‐aging bioactive lipids implicated in both metabolic dysfunction and musculoskeletal decline.
Park SJ, Baek JY, Wei S, Lee JY, Lee Y, Lee SH, Jang IY, Sakong H, Yoo HJ, Jung HW, Lee E, Kim SJ, Jo Y, Kim K, Ryu D, Kim BJ.   +15 more
europepmc   +2 more sources

The Physical Properties of Ceramides in Membranes

, 2018
Ceramides are sphingolipids containing a sphingosine or a related base, to which a fatty acid is linked through an amide bond. When incorporated into a lipid bilayer, ceramides exhibit a number of properties not shared by almost any other membrane lipid:
Alonso, Alicia, Félix M. Goñi, Alicia Alonso, Goñi, Félix M.   +3 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Harnessing bacterial extracellular vesicles for bone and cartilage organoids

BMEMat, EarlyView.
This review presents bacterial extracellular vesicles (BEVs) as programmable bioactive regulators for bone and cartilage organoids by delivering functional cargos that modulate skeletal remodeling. It highlights key engineering strategies and future directions to advance next‐generation organoid models for bone aging related diseases.
Han Liu, Xukun Lv, Ting Cheng, Lei Yan, Yuxiao Lai, Keying Guo, Yingying Jing, Hao Shen, Jiacan Su   +8 more
wiley   +1 more source

Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology

Nature Communications, 2022
Among lipid classes, ceramides are linked to impaired cardiometabolic health. Here the authors report the association of specific ceramides and dihydroceramides on the risk of developing type 2 diabetes and or cardiovascular disease in a prospective ...
C. Wittenbecher, R. Cuadrat, L. Johnston, F. Eichelmann, S. Jäger, O. Kuxhaus, M. Prada, F. Del Greco M., A. A. Hicks, P. Hoffman, J. Krumsiek, F. B. Hu, M. B. Schulze   +12 more
doaj   +1 more source

Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil, Sathej Gopalakrishnan, Jennifer Dong, Karthik Venkatakrishnan, Charlotte Kloft, Wilhelm Huisinga, Lena Klopp‐Schulze   +6 more
wiley   +1 more source