Results 81 to 90 of about 31,716 (293)

Nanostructured Deep Eutectic Systems in Healthcare: From Bioactive Solvents to Intelligent Biointerfaces, Wearables, and AI‐Driven Design

Advanced NanoBiomed Research, EarlyView.
Beyond the green solvent paradigm, this review redefines Deep Eutectic Systems (DES) as programmable supramolecular nanoassemblies. We survey their biomedical convergence: stabilizing thermolabile mRNA to enable cold chain‐free logistics, reshaping transdermal microneedle delivery, enabling long‐term wearables via eutectogels, and utilizing Generative ...
Jeesu Moon, Min Seo Kim, Jae‐Seung Lee
wiley   +1 more source

Ceramides of pig epidermis: structure determination

Journal of Lipid Research, 1983
Seven distinguishable groups of ceramides have been isolated from pig epidermis and identified. In order of increasing polarity there are: 1, N-(omega-acyloxy)acylsphingosines (7.7%); 2, N-acylsphingosines (42.4%); 3, N-acylphytosphingosines (10.2%); 4 ...
P W Wertz, D T Downing
doaj   +1 more source

Scalable Synthesis of Human Ultralong Chain Ceramides

, 2015
Ceramides with ultralong chains (≥30 carbons), also known as acylceramides, play a critical role in the survival of mammals on dry land. An efficient and scalable synthesis of four major classes of ultralong human skin ceramides is reported.
Michaela Sochorová (1233543), Andrej Kováčik (1233540), Kateřina Vávrová (1233546), Jiří Kuneš (1233537), Juraj Lenčo (1233534), Lukáš Opálka (1233552), Jaroslav Roh (1233549)   +6 more
core   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Effect of combined testing of ceramides with high-sensitive troponin T on the detection of acute coronary syndrome in patients with chest pain in China: a prospective observational study

BMJ Open, 2019
Objective Ceramides are associated with coronary plaque vulnerability. We aim to investigate the potential diagnostic value of ceramides for acute coronary syndrome (ACS) in Chinese patients with chest pain.Design Prospective observational survey.Setting
Wei Hu, Junbo Ge, Juying Qian, Zhe Wang, Xuebo Liu, Yanzhong Wang, Demin Xu, Chengxing Shen, Runda Wu, Xianglin Tang, Aijun Sun, Yunzeng Zou, Guangyu Wu, Xiaoliang Cheng   +13 more
doaj   +1 more source

Ceramides improve accuracy in prediction of preclinical atherosclerosis

, 2018
Background: Ceramides are known to predict clinical cardiovascular diseases, but their role in prediction of subclinical atherosclerosis is unknown.
Laaksonen, Reijo (6899744), Lehtimäki, Terho, Lehtimäki, Terho (6899747), Lyytikäinen, Leo-Pekka, Lyytikäinen, Leo-Pekka (6899735), Kähönen, Mika, Raitakari, Olli, Mishra, Pashupati, Mishra, Pashupati (6899732), Laaksonen, Reijo, Kähönen, Mika (6899738), Raitakari, Olli (6899741)   +11 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Role of dietary and nutritional interventions in ceramide-associated diseases

Journal of Lipid Research
Ceramides are important intermediates in sphingolipid metabolism and serve as signaling molecules with independent biological significance. Elevated cellular and circulating ceramide levels are consistently associated with pathological conditions ...
Shengnan Wang, Zihui Jin, Biyu Wu, Andrew J. Morris, Pan Deng   +4 more
doaj   +1 more source