Results 101 to 110 of about 32,676 (287)
Metrnl: A Novel Therapeutic Target in Atherosclerosis
iNew Medicine, EarlyView.ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source
Ceramides stimulate caspase-14 expression in human keratinocytes. [PDF]
, 2013 Caspase-14 is an enzyme that is expressed predominantly in cornifying epithelia and catalyses the degradation of profilaggrin. Additionally, caspase-14 plays an important role in the terminal differentiation of keratinocytes.
Elias, Peter +6 more
core +1 more source
iNew Medicine, EarlyView.This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley +1 more source
Journal of Lipid Research, 2005 Lipid lamellae present in the outermost layer of the skin, the stratum corneum, form the main barrier for the diffusion of molecules through the skin.
Miranda W. de Jager +3 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari +7 more
wiley +1 more source
Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis.
PLoS ONE, 2015 Cardiovascular disease (CVD) is a serious comorbidity in nonalcoholic fatty liver disease (NAFLD). Since plasma ceramides are increased in NAFLD and sphingomyelin, a ceramide metabolite, is an independent risk factor for CVD, the role of ceramides in ...
Takhar Kasumov +9 more
doaj +1 more source
Use of a Bacteriophage Lysin to Control Axillary Malodor
JEADV Clinical Practice, EarlyView.ABSTRACT Background Axillary malodor is primarily caused by bacteria, particularly Staphylococcus hominis, which metabolize apocrine secretions into volatile compounds. Traditional deodorants contain antiseptics that can disrupt the skin microbiome and cause irritation. Alternative methods of odor control are being sought but so far without success. We
Maurice A. M. van Steensel +3 more
wiley +1 more source
Visualizing bioactive ceramides
Chemistry and Physics of Lipids, 2018 In the last 30 years, ceramides have been found to mediate a myriad of biological processes. Ceramides have been recognized as bioactive molecules and their metabolizing enzymes are attractive targets in cancer therapy and other diseases. The molecular mechanism of action of cellular ceramides are still not fully established, with insights into roles ...
Daniel Canals +2 more
openaire +3 more sources
Synthesis of ceramides with deuterated sphingosine
, 2013 Ceramides are a complex group of lipids belonging to sphingolipids. They are the most important component of stratum corneum (SC) and thus participate in a barrier function of the skin.
Havlíčková, Kateřina
core
JEADV Clinical Practice, EarlyView.ABSTRACT Emollients and cleansers are essential components in managing atopic dermatitis (AD). While international evidence‐based guidelines recommend using gentle cleansers and emollients daily as a foundational therapy for AD, implementation in practice remains suboptimal.
Mette Deleuran +12 more
wiley +1 more source