Results 111 to 120 of about 41,371 (294)

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

The decline in muscle strength and muscle quality in relation to metabolic derangements in adult women with obesity [PDF]

, 2019
Background & aims: The metabolic and functional characteristics related to sarcopenic obesity have not been thoroughly explored in the earlier stages of the aging process.
Catalano, Carlo, Di Martino, Michele, Donini, Lorenzo Maria, Gnessi, Lucio, Lenzi, Andrea, Lubrano, Carla, Mariani, Stefania, Poggiogalle, Eleonora   +7 more
core   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Synthesis of ceramides using N-hydroxysuccinimide esters

Journal of Lipid Research, 1972
Fatty acyl esters of N-hYdroxYSuccinimide have been used to directly N-acylate sphingenine or sphinganine, forming the corresponding ceramides. The reaction proceeds in excellent yield (84–96%) from small amounts of starting material (10–20 mg).
David E. Ong, Robert N. Brady
doaj   +1 more source

Intracellular trafficking of ceramide by ceramide transfer protein

Proceedings of the Japan Academy, Series B, 2010
The transport and sorting of lipids are fundamental to membrane biogenesis. In the synthesis of sphingolipids in mammalian cells, ceramide is newly produced at the endoplasmic reticulum (ER), and transported from the ER to the trans Golgi regions, where it is converted to sphingomyelin.
openaire   +3 more sources

Gas-liquid chromatography-mass spectrometry of synthetic ceramides containing phytosphingosine

Journal of Lipid Research, 1970
Ceramides containing phytosphingosine as base and one of the fatty acids 16:0, 18:0, 20:0, 22:0, 23:0, and 24:0, were prepared by direct coupling in the presence of a mixed carbodiimide. The ceramides were analyzed as the 1,3,4-tri-O-trimethylsilyl ether
Sven Hammarström
doaj   +1 more source

Selective Knockdown of Ceramide Synthases Reveals Opposite Roles of Different Ceramide Species in Cardiac Homeostasis

Metabolites
Background/Objectives: Sphingolipids are a class of lipids that play important structural and functional roles in the cell. Specific ceramide species are distinguishable through the fatty acid that is acylated to the sphingosine backbone, leading to ...
Alexandra M. Wiley, Melissa A. Krueger, Jessica O. Becker, Matthew Karasu, Nona Sotoodehnia, Jason G. Umans, Andrew N. Hoofnagle, Sina A. Gharib, Rheem A. Totah, Rozenn N. Lemaitre   +9 more
doaj   +1 more source

A convenient procedure for the synthesis of ceramides

Journal of Lipid Research, 1971
A procedure for the preparation of ceramides by direct coupling of long-chain bases and fatty acids in the presence of a mixed carbodiimide is described.
Sven Hammarström
doaj   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Functionally complementary bacterial inoculant coordinates arbuscular mycorrhizal fungi to improve Angelica sinensis root yield and quality

iMetaOmics, EarlyView.
Comprehensive understanding of how diverse PGPR strains enhance the rhizosphere microenvironment remains a considerable challenge. Here, we provide experimental evidence that a functionally synergistic composite microbial formulation can markedly enhance growth performance and improve the quality attributes in Angelica sinensis.
Zongyu Zhang, Yun Wang, Jiecai Zhao, Gaofeng Chen, Andéole Niyongabo Turatsinze, Liang Yue, Yuan Tian, Xiaofan Xie, Ailing Ye, Meilan Zhang, Lingling Wu, Zengxiang Guo, Yubao Zhang, Ruoyu Wang   +13 more
wiley   +1 more source