Results 21 to 30 of about 244,453 (253)
Skin-associated adipocytes in skin barrier immunity: A mini-review
Frontiers in Immunology, 2023 The skin contributes critically to health via its role as a barrier tissue against a multitude of external pathogens. The barrier function of the skin largely depends on the uppermost epidermal layer which is reinforced by skin barrier immunity.
Jingyan Guan +3 more
doaj +1 more source
Skin Barrier and Calcium [PDF]
Annals of Dermatology, 2018 Epidermal barrier formation and the maintenance of barrier homeostasis are essential to protect us from the external environments and organisms. Moreover, impaired keratinocytes differentiation and dysfunctional skin barrier can be the primary causes or aggravating factors for many inflammatory skin diseases including atopic dermatitis and psoriasis ...
Sang Eun Lee, Seung Hun Lee
openaire +3 more sources
Gentiana lutea Extract Modulates Ceramide Synthesis in Primary and Psoriasis-Like Keratinocytes
Molecules, 2020 Gentiana lutea is a bitter herb that is traditionally used to improve gastric disorders. Recently, we have shown that Gentiana lutea extract (GE) also modulates the lipid metabolism of human keratinocytes in vitro and in vivo.
Fabian Gendrisch +6 more
doaj +1 more source
Skin barrier immunity and ageing [PDF]
Immunology, 2019 SummaryThe skin is the outermost layer of the body with an extensive surface area of approximately 1·8 m2, and is the first line of defence against a multitude of external pathogens and environmental insults. The skin also has important homeostatic functions such as reducing water loss and contributing to thermoregulation of the body.
Emma S. Chambers +1 more
openaire +4 more sources
Scientific Reports, 2017 Ceramide (Cer) release from glucosylceramides (GlcCer) is critical for the formation of the skin permeability barrier. Changes in β-glucocerebrosidase (GlcCer’ase) activity lead to diminished Cer, GlcCer accumulation and structural defects in SC lipid ...
Michaela Sochorová +5 more
doaj +1 more source
Skin barrier in the neonate [PDF]
Pediatric Dermatology, 2018 AbstractThe purpose of this review is to focus on determinants of skin barrier function in neonates at molecular and cellular levels. The skin barrier is critical in terms of water and gas exchanges during fetal life and undergoes rapid changes at birth, followed by a progressive maturation.
openaire +2 more sources
Skin Microbiota and the Skin Barrier
International Journal of Dermatology and Venereology, 2023 The skin constitutes the primary barrier between the human body and the external environment. The skin microbiome plays an important role in the microecosystem on the skin surface and mediates multiple facets of the skin barrier function, including physical, chemical, microbial, and immune barriers.
Ming-Yang Wu, Xu Yao
openaire +1 more source
European Pharmaceutical Journal, 2017 The skin barrier, which is essential for human survival on dry land, is located in the uppermost skin layer, the stratum corneum. The stratum corneum consists of corneocytes surrounded by multilamellar lipid membranes that prevent excessive water loss ...
Vávrová K., Kováčik A., Opálka L.
doaj +1 more source
Long and very long lamellar phases in model stratum corneum lipid membranes
Journal of Lipid Research, 2019 Membrane models of the stratum corneum (SC) lipid barrier, either healthy or affected by recessive X-linked ichthyosis, constructed from ceramide [Cer; nonhydroxyacyl sphingosine N-tetracosanoyl-d-erythro-sphingosine (CerNS24) alone or with omega-O ...
Petra Pullmannová +7 more
doaj +1 more source
Current Allergy and Asthma Reports, 2008 Like other inflammatory dermatoses, the pathogenesis of atopic dermatitis (AD) has been largely attributed to abnormalities in adaptive immunity. T helper (Th) cell types 1 and 2 cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling are thought to account for the chronic, pruritic, and inflammatory dermatosis that ...
openaire +2 more sources