Results 1 to 10 of about 7,455 (218)

Edible Bird’s Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte [PDF]

Frontiers in Pharmacology, 2021
Edible bird’s nest (EBN) has been consumed as a Chinese delicacy for hundreds of years; the functions of which have been proposed to prevent lung disease, strengthen immune response, and restore skin youthfulness. To support the skin function of EBN, the
Queenie Wing Sze Lai, Queenie Wing Sze Lai, Maggie Sui Sui Guo, Maggie Sui Sui Guo, Kevin Qiyun Wu, Kevin Qiyun Wu, Zhitao Liao, Dongshi Guan, Tina Tingxia Dong, Tina Tingxia Dong, Penger Tong, Karl Wah Keung Tsim, Karl Wah Keung Tsim   +12 more
doaj   +6 more sources

Remodeling of the cell membrane-associated protein pool affects adhesive membrane properties in filaggrin insufficient keratinocytes and impacts distinct cellular and organellar functions [PDF]

BMC Biology
Background Atopic dermatitis (AD) is a highly prevalent inflammatory skin disease, affecting up to 30% of children at some point in their life and frequently persisting into adulthood.
Adrian Kobiela, Mikołaj Klimczuk, Paweł Kamil Serafin, Kamila Kitowska, Anna Biernacka, Reza Abouali, Jorge Bernardino de la Serna, Xinwen Wang, Felicja Gajdowska, Aniela Kosobucka, Aleksandra Małgorzata Siedlar, Amandine Hauer, Lilit Hovhannisyan, Aleksandra Bogucka, Jos P. H. Smits, Ellen H. van den Bogaard, Rafał Sądej, Graham S. Ogg, Danuta Gutowska-Owsiak   +18 more
doaj   +2 more sources

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response [PDF]

Brazilian Journal of Medical and Biological Research, 2014
The objective of this study was to investigate whether a single defect in skin barrier function simulated by filaggrin silencing could induce Th2-predominant inflammation.
N.N. Dang, S.G. Pang, H.Y. Song, L.G. An, X.L. Ma   +4 more
doaj   +5 more sources

Modulation of Moisturizing and Barrier Related Molecular Markers by Extracellular Vesicles Derived from Leuconostoc mesenteroides DB-21 Isolated from Camellia japonica Flower [PDF]

Current Issues in Molecular Biology
Among the microorganisms present in the microbiome of Camellia japonica flowers, extracellular vesicles (EVs) derived from Leuconostoc mesenteroides were isolated to investigate their modulatory effects on moisturizing and barrier-related molecular ...
Junseok Baek, Seongguk Cho, Gibok Lee, Hosam Ki, Su Young Kim, Gyu-min Choi, Jae Hong Kim, Ji-Woong Kim, Chang-Min Park, Seung-Young Kim, Byeong-Min Choi, Yang Gyu Choi   +11 more
doaj   +2 more sources

Cannabidiol Mitigates Pollution-Induced Inflammatory, Oxidative, and Barrier Damage in Ex Vivo Human Skin [PDF]

Biomolecules
Airborne particulate matter (PM) is a major environmental pollutant that accelerates skin aging, inflammation, and barrier impairment. Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has shown anti-inflammatory and ...
Wannita Klinngam, Orathai Loruthai, Sornkanok Vimolmangkang   +2 more
doaj   +2 more sources

Filaggrin and Atopic Dermatitis: Clinical and Pathogenetic Parallels and Therapeutic Possibilities

Вопросы современной педиатрии, 2021
Atopic dermatitis (AtD) is multifactorial inflammatory skin disease, one of the aspects of its pathogenesis is epidermal barrier dysfunction. Early development of AtD is associated with filaggrin dysfunction.
Nikolay N. Murashkin, Roman A. Ivanov, Eduard T. Ambarchian, Roman V. Epishev, Alexander I. Materikin, Leonid A. Opryatin, Alena A. Savelova   +6 more
doaj   +1 more source

Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2021
We examined whether it is possible to directly detect citrullinated antigens in the serum of rheumatoid arthritis (RA) patients using a monoclonal antibody (mAb) designed to be specific for citrullinated peptides. In order to confirm the potential of the
Pureun Won, Pureun Won, Youngkyun Kim, Youngkyun Kim, Youngkyun Kim, Hyerin Jung, Hyerin Jung, Yeri Alice Rim, Yeri Alice Rim, Dong Hyun Sohn, Dong Hyun Sohn, Dong Hyun Sohn, William H. Robinson, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju   +17 more
doaj   +1 more source

Modern View on the Role of Epidermal Barrier in Atopic Phenotype Development in Children

Вопросы современной педиатрии, 2020
Epidermal barrier is one is one of the most important structures of the skin, it performs protective function, ensure internal environment constancy by selective ions and molecules transport and by transepidermal water loss regulation.
Nikolay N. Murashkin, Alena A. Savelova, Roman A. Ivanov, Dmitri V. Fedorov, Leonid A. Opryatin, Wasel Ahmad   +5 more
doaj   +1 more source

Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.

PLoS ONE, 2020
Skin aspartic acid protease (SASPase) is believed to be a key enzyme involved in filaggrin processing during epidermal terminal differentiation. Since little is known about the regulation of SASPase function, the aim of this study was to identify ...
Mark Donovan, Mélanie Salamito, Agnès Thomas-Collignon, Lucie Simonetti, Stephanie Desbouis, Jean-Christophe Rain, Etienne Formstecher, Dominique Bernard   +7 more
doaj   +1 more source

Expression of keratins, epidermal proteins and inflammatory cells in superficial pemphigus dogs [PDF]

Bulgarian Journal of Veterinary Medicine, 2018
Superficial pemphigus in dogs is an autoimmune skin disorder. The disease is characterised by the binding of auto-antibodies to desmosomal molecules including desmocollin-1, a major auto-antigen in dogs.
S. Theerawatanasirikul, A. Rungsipipat, W. Banlunara , P. Pongket   +3 more
doaj   +1 more source