Results 41 to 50 of about 7,455 (218)

Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes [PDF]

, 2011
Summary Background The identification of filaggrin mutations has contributed towards our understanding of hereditary factors associated with epidermal dysfunction observed in individuals with atopic eczema (AE).
Ogg, GS, Gutowska-Owsiak, D, Salimi, M, A.L. Schaupp, D. Gutowska-Owsiak, Taylor, Stephen, M. Salimi, Schaupp, AL, S. Taylor, G.S. Ogg   +9 more
core   +1 more source

Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased transcriptional-translational activity, keratinocyte-immune crosstalk and disordered axon guidance [version 1; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2019
Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads
Martina S. Elias, Sheila C. Wright, William V. Nicholson, Kimberley D. Morrison, Alan R. Prescott, Sara Ten Have, Phillip D. Whitfield, Angus I. Lamond, Sara J. Brown   +8 more
doaj   +1 more source

Evolutionary diversification of epidermal barrier genes in amphibians

Scientific Reports, 2022
The epidermal differentiation complex (EDC) is a cluster of genes encoding components of the skin barrier in terrestrial vertebrates. EDC genes can be categorized as S100 fused-type protein (SFTP) genes such as filaggrin, which contain two coding exons ...
Attila Placido Sachslehner, Leopold Eckhart   +1 more
doaj   +1 more source

Epidermal Immunity and Function: Origin in Neonatal Skin

Frontiers in Molecular Biosciences, 2022
The fascinating story of epidermal immunity begins in utero where the epidermal barrier derives from the ectoderm and evolves through carefully orchestrated biological processes, including periderm formation, keratinocyte differentiation, proliferation ...
Marty O. Visscher, Andrew N. Carr, Vivek Narendran   +2 more
doaj   +1 more source

DS_10.1369_0022155418798807 – Supplemental material for Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin [PDF]

, 2018
Supplemental material, DS_10.1369_0022155418798807 for Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin by Didier Pin, Valérie Pendaries, Sokhna Keita Alassane, Carine ...
Nicolas Amalric (5736962), Emilie Vidémont (5736965), Valérie Pendaries (5736959), Sokhna Keita Alassane (4268356), Marek Haftek (3140574), Carine Froment (848571), Michel Simon (270124), Marie-Christine Cadiergues (3607328), Guy Serre (48155), Didier Pin (5736956)   +9 more
core   +1 more source

RETRACTED ARTICLE: Topical bismuth oxide-manganese composite nanospheres alleviate atopic dermatitis-like inflammation

Journal of Nanobiotechnology, 2023
Atopic dermatitis (AD) is a common skin disease involving important immune mechanisms. There is an unmet need for a treatment for this condition. Herein, we focused on elucidating the role of Bi2-xMnxO3 nanospheres (BM) in alleviating skin inflammation ...
Mengjie Li, Benjin Chen, Lingling Xu, Yu Wang, Zhu Chen, Bingyan Ma, Shichun Qin, Yechun Jiang, Cheng Gu, Haisheng Qian, Fengli Xiao   +10 more
doaj   +1 more source

Filaggrin loss-of-function mutations and association with allergic diseases. [PDF]

, 2008
Human skin constitutes a highly organized barrier against environmental agents. Its unrestricted function depends on a complex interplay between multiple proteins and lipids expressed in the terminally differentiating epithelium.
Weidinger, S., Illig, T., Rodriguez, E.
core   +1 more source

Skin barrier in atopic dermatitis: beyond filaggrin [PDF]

Anais Brasileiros de Dermatologia, 2016
: Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors.
Mariana Colombini Zaniboni, Luciana Paula Samorano, Raquel Leão Orfali, Valéria Aoki   +3 more
doaj   +1 more source

Identification of Filaggrin in Cultured Mouse Keratinocytes and Its Regulation by Calcium [PDF]

, 1983
Filaggrin is a histidine-rich cationic protein present in cells of the stratum corneum in vivo and derived from a precursor in keratohyalin granules. Biochemical and immunologic methods were used to determine the presence of filaggrin in keratinocytes ...
Stanley, John R., Hennings, Henry, Beverly A. Dale, Stuart H. Yuspa, John R. Stanley, Haugen Scofield, Julie A., Henry Hennings, Yuspa, Stuart H., Julie A. Haugen Scofield, Dale, Beverly A.   +9 more
core   +1 more source

Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells

Scientific Reports, 2020
Active ingredients derived from natural sources are widely utilized in many industries. Cosmetic active ingredients are largely derived from various plants.
Kyung-Ha Lee, Jeong Pyo Lee, Wanil Kim
doaj   +1 more source