The Role of MicroRNAs in Epidermal Barrier [PDF]
International Journal of Molecular Sciences, 2020 MicroRNAs (miRNAs), which mostly cause target gene silencing via transcriptional repression and degradation of target mRNAs, regulate a plethora of cellular activities, such as cell growth, differentiation, development, and apoptosis. In the case of skin
Ai-Young Lee
exaly +6 more sources
Five Functional Aspects of the Epidermal Barrier. [PDF]
Int J Mol Sci, 2021 The epidermis is a living, multilayered barrier with five functional levels, including a physical, a chemical, a microbial, a neuronal, and an immune level.
Lefèvre-Utile A +3 more
europepmc +7 more sources
Epidermal Barrier Integrity is Associated with Both Skin Microbiome Diversity and Composition in Patients with Acne Vulgaris [PDF]
Clinical, Cosmetic and Investigational Dermatology, 2022 Lin Zhou,1 Xueping Liu,1 Xulin Li,1 Xiangyan He,1 Xia Xiong,1,* Jingdong Lai2,* 1Department of Dermatology & STD, The Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Department of Dermatology & STD ...
Zhou L +5 more
doaj +3 more sources
Molecular Mechanism of Epidermal Barrier Dysfunction as Primary Abnormalities [PDF]
International Journal of Molecular Sciences, 2020 Epidermal barrier integrity could be influenced by various factors involved in epidermal cell differentiation and proliferation, cell–cell adhesion, and skin lipids. Dysfunction of this barrier can cause skin disorders, including eczema.
Ai-Young Lee
exaly +3 more sources
The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update. [PDF]
Front Mol Biosci, 2023 Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disease with various clinical presentations and combinations of symptoms. The pathophysiology of AD is complex and multifactorial.
Çetinarslan T +2 more
europepmc +2 more sources
Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]
Cells, 2020 Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung +19 more
core +2 more sources
Epidermal Barrier Function and Skin Homeostasis in Atopic Dermatitis: The Impact of Age. [PDF]
Life (Basel), 2022 Skin is damaged in atopic dermatitis (AD) patients. Age is also believed to have a negative effect on epidermal barrier function. The aim of this study was to investigate skin barrier function changes with age in AD patients.
Montero-Vilchez T +7 more
europepmc +2 more sources
The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier. [PDF]
Front Immunol, 2021 The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked.
Macleod T +5 more
europepmc +2 more sources
The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis-An Update. [PDF]
Int J Mol Sci, 2021 Atopic dermatitis (AD) is a common inflammatory dermatosis affecting up to 30% of children and 10% of adults worldwide. AD is primarily driven by an epidermal barrier defect which triggers immune dysregulation within the skin.
Blicharz L +6 more
europepmc +2 more sources
Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier. [PDF]
Int J Mol Sci, 2021 The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress ...
Danis J, Mellett M.
europepmc +2 more sources