The Role of MicroRNAs in Epidermal Barrier [PDF]
International Journal of Molecular Sciences, 2020 MicroRNAs (miRNAs), which mostly cause target gene silencing via transcriptional repression and degradation of target mRNAs, regulate a plethora of cellular activities, such as cell growth, differentiation, development, and apoptosis. In the case of skin keratinocytes, the role of miRNA in epidermal barrier integrity has been identified.
Ai-Young Lee
exaly +5 more sources
Comparison of Epidermal Barrier Integrity in Adults with Classic Atopic Dermatitis, Atopic Prurigo and Non-Atopic Prurigo Nodularis [PDF]
Biology, 2021 A deficient epidermal barrier is a key feature of atopic dermatitis (AD) and comprises altered lipid and protein content and composition of the stratum corneum resulting in disturbed water balance.
Regina Fölster-Holst +9 more
doaj +2 more sources
Five Functional Aspects of the Epidermal Barrier. [PDF]
Int J Mol Sci, 2021 The epidermis is a living, multilayered barrier with five functional levels, including a physical, a chemical, a microbial, a neuronal, and an immune level. Altogether, this complex organ contributes to protect the host from external aggression and to preserve its integrity. In this review, we focused on the different functional aspects.
Lefèvre-Utile A +3 more
europepmc +6 more sources
Umbelliferone preserves skin epidermal barrier integrity in diabetes-induced keratinocytes by regulating actin dynamics and suppressing ROS-mediated apoptosis [PDF]
Nutrition & DiabetesBackground The skin serves as a fundamental protective barrier against environmental insults, with the epidermis, particularly the stratum corneum and tight junctions (TJs) connecting keratinocytes, playing a crucial role.
Dong Yeon Kim +2 more
doaj +2 more sources
The 4E-BP1 deletion modestly mitigates mTORC1-deficient epidermal barrier defects [PDF]
JID InnovationsmTOR signaling is essential for epidermal development, yet the downstream mechanisms mediating its effects remain unclear. The 4E-BP1 (eukaryotic initiation factor 4E-binding protein 1), a major mTORC1 target that inhibits cap-dependent translation, has ...
Huihao Tang +7 more
doaj +2 more sources
Pharmacological Targeting of the Epidermal Barrier [PDF]
Current Pharmaceutical Design, 2016 The most important function of the skin is to form a barrier between the body and the external environment. The epidermal barrier prevents transepidermal water loss from the skin, but also serves as a barrier to the entry of harmful environmental allergic, toxic or infectious substances.
Eros Gabor +2 more
exaly +4 more sources
β-endorphin suppresses ultraviolet B irradiation-induced epidermal barrier damage by regulating inflammation-dependent mTORC1 signaling [PDF]
Scientific Reports, 2023 Solar ultraviolet B (UVB) radiation triggers excessive inflammation, disrupting the epidermal barrier, and can eventually cause skin cancer. A previous study reported that under UVB irradiation, epidermal keratinocytes synthesize the proopiomelanocortin ...
Hyung-Su Kim +4 more
doaj +2 more sources
Bioconversion of BIOGF1K, a compound-K-rich fraction from ginseng root and its effect on epidermal barrier function [PDF]
Heliyon, 2023 BIOGF1K, the ginseng root-based and hydrolyzed ginsenoside-rich fraction, is known to improve skin damage, but there are rare studies on the kinetic of ginsenosides in the epidermis and their effects on epidermal barrier function.
Woo-Hyun Kim +7 more
doaj +2 more sources
Epidermal Barrier Integrity is Associated with Both Skin Microbiome Diversity and Composition in Patients with Acne Vulgaris [PDF]
Clinical, Cosmetic and Investigational Dermatology, 2022 Lin Zhou,1 Xueping Liu,1 Xulin Li,1 Xiangyan He,1 Xia Xiong,1,* Jingdong Lai2,* 1Department of Dermatology & STD, The Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Department of Dermatology & STD ...
Zhou L +5 more
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Light repair effect of polysaccharides component from white Ganoderma lucidum and Laminaria japonica fermentation broth attenuates epidermal barrier dysfunction via TRPV4-Keap-1/Nrf2 pathway [PDF]
Bioresources and BioprocessingEpidermal photoinflammation has emerged as an atypical pathological response that poses a growing global threat to human health and well-being. In this study, a polysaccharide component (named LJGp) was isolated from Laminaria japonica and white ...
Xinrui Jiang +8 more
doaj +2 more sources