Results 41 to 50 of about 2,098,761 (326)

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation [PDF]

, 2012
ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously expressed and cleaves membrane proteins, such as epidermal growth factor receptor (EGFR) ligands, l-selectin, and TNF, from the cell surface, thus regulating responses to tissue injury and ...
Blobel, C.P., Bruckner-Tuderman, L., Cobzaru, C., Franzke, C.W., Horiuchi, K., Kurz, T., Loffek, S., Rooijen, N. van, Threadgill, D.W., Triantafyllopoulou, A.   +9 more
core   +1 more source

Beneficial autoimmunity at body surfaces – immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer [PDF]

, 2014
Epithelial cells line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental ...
Agrawal, Aguado, Al-Shami, Allakhverdi, Angkasekwinai, Arwert, Balkwill, Bas, Björkström, Blais, Boyden, Briot, Bryson, Burnet, Burnet, Cella, Cerwenka, Champsaur, Chan, Chao, Chavanas, Chen, Chen, Cheroutre, Conticello, Coussens, Culig, Dalton, Dearman, Deleuran, Demehri, DePinho, Devey, Di Piazza, Dighe, Dunham, Dunn, Dvorak, Ehrlich, Eisenbarth, Ellyard, Engkilde, Eyerich, Farhadi, Felices, Fort, Fritz, Fujisawa, Fukuyama, Furmanski, Fux, Gause, Gebhardt, Giangreco, Girardi, Girardi, Girardi, Golumbek, Gregory, Groh, Gutierrez, Hallett, Hammad, Hams, Harris, Hayday, Heneghan, Hock, Hueber, Humphreys, Imai, Indra, Jackson, Jameson, Jameson, Jensen-Jarolim, Jerde, Jiang, Jiang, Josephs, Jotwani, Jovanovic, Jovanovic, Jung, Kaplan, Karagiannis, Kim, Komai-Koma, Kool, Kool, Kouzaki, Kuroda, Lebel-Binay, Lee, Lindelof, Lodoen, Ma, Magalhaes, Magalhaes, Marichal, Marichal, Matsuda, Matzinger, McCoy, McWhorter, Meehan, Metz, Mishra, Moghaddam, Monticelli, Nestle, Nigro, Obiri, Oh, Okumura, Olver, Ortiz-Urda, Owyang, Palm, Palm, Park, Pastorelli, Pearce, Pedroza-Gonzalez, Pericle, Profet, Qi, Ramsbottom, Raulet, Reali, Renard, Rittmeyer, Rodolfo, Rosenberg, Rölle, Saenz, Sagiv, Salgame, Salimi, Schmidt, Schmitz, Schneider, Schonthaler, Senovilla, Shankaran, Sharp, Sherman, Shi, Shibuya, Simson, Skinnider, Smyth, Soriani, South, Strid, Strid, Strid, Suárez-Alvarez, Swamy, Takahashi, Takai, Tan, Tang, Thomas, Traidl-Hoffmann, Turchinovich, Ullrich, Van Belle, Van Hemelrijck, Vantourout, Verdino, Vernersson, Vesely, Villarreal, Walley, Walter, Wang, Wen, Wen, Wilson, Witherden, Witherden, Wood, Yanaba, Yin, Yoo, Zaiss, Zaph, Zaph, Ziegler, Zitvogel   +190 more
core   +6 more sources

Effect of cutaneous permeability barrier disruption on HMG-CoA reductase, LDL receptor, and apolipoprotein E mRNA levels in the epidermis of hairless mice.

Journal of Lipid Research, 1992
Disruption of the permeability barrier results in an increase in cholesterol synthesis in the epidermis. Inhibition of cholesterol synthesis impairs the repair and maintenance of barrier function.
S M Jackson, L C Wood, S Lauer, J M Taylor, A D Cooper, P M Elias, K R Feingold   +6 more
doaj   +1 more source

Impact of Age and Body Site on Adult Female Skin Surface pH [PDF]

, 2012
Background: pH is known as an important parameter in epidermal barrier function and homeostasis. Aim: The impact of age and body site on skin surface pH (pH(SS)) of women was evaluated in vivo.
Barbara Behm, Barland CO, Behne MJ, Behne MJ, Braun-Falco O, Choi EH, Dikstein S, Elias PM, Fluhr JW, Fluhr JW, Ghadially R, Ghadially R, Giusti F, Hachem JP, Hans Christian Korting, Hoeger PH, Kim EJ, Kocinkova AS, Korting HC, Korting HC, Kürner JM, Lambers H, Liebsch G, Mauro T, Michael Landthaler, Philipp Babilas, Posch HE, Robert Johannes Meier, Schmid-Wendtner MH, Schmuth M, Schreml S, Schreml S, Seyfarth F, Stephan Schreml, Takagi Y, Veronika Zeller, Wilhelm KP, Ye J, Yosipovitch G, Yosipovitch G, Zlotogorski A   +40 more
core   +2 more sources

Bricks and mortar of the epidermal barrier [PDF]

Experimental & Molecular Medicine, 1999
A specialized tissue type, the keratinizing epithelium, protects terrestrial mammals from water loss and noxious physical, chemical and mechanical insults. This barrier between the body and the environment is constantly maintained by reproduction of inner living epidermal keratinocytes which undergo a process of terminal differentiation and then ...
Z, Nemes, P M, Steinert
openaire   +2 more sources

Epidermal Barrier Dysfunction in Atopic Dermatitis

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2021
Impaired skin barrier is one of the hallmarks of atopic dermatitis (AD), with abnormalities in the cornified envelope, lipid lamellae, tight junctions and cutaneous microbiome.
Tiago Fernandes Gomes, Rebeca Calado, Margarida Gonçalo   +2 more
doaj   +1 more source

Evolutionary origin and diversification of epidermal barrier proteins in amniotes. [PDF]

, 2014
The evolution of amniotes has involved major molecular innovations in the epidermis. In particular, distinct structural proteins that undergo covalent cross-linking during cornification of keratinocytes facilitate the formation of mechanically resilient ...
Alibardi, Lorenzo, Eckhart, Leopold, Eigenheer, Richard A, Hermann, Marcela, Mlitz, Veronika, Rice, Robert H, Strasser, Bettina, Tschachler, Erwin   +7 more
core   +1 more source

Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently

Scientific Reports, 2020
The transmembrane protein claudin-1 is a major component of epidermal tight junctions (TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 downregulation has been linked to atopic dermatitis (AD) pathogenesis but variable levels
Sophia Bergmann, Barbara von Buenau, S. Vidal-y-Sy, M. Haftek, E. Wladykowski, P. Houdek, S. Lezius, H. Duplan, K. Bäsler, S. Dähnhardt-Pfeiffer, C. Gorzelanny, S. Schneider, E. Rodriguez, D. Stölzl, S. Weidinger, J. Brandner   +15 more
semanticscholar   +1 more source

The Epidermal Barrier

Journal of Investigative Dermatology, 1961
The barrier to epidermal absorption and to water loss has been given much attention in recent years (1, 3, 5, 7, 8, 10). The purpose of this paper is not to consider the location of the barrier or the mechanism of penetration but rather to report the differences between the functional barrier of scrotal skin and that of abdominal skin and mucous ...
Smith Jr., J. Graham, Fischer, Robert W., Blank, Harvey   +2 more
openaire   +1 more source

Permeability barrier requirements regulate epidermal beta-glucocerebrosidase.

Journal of Lipid Research, 1994
The intercellular spaces of the outermost layers of the epidermis (stratum corneum, SC) of terrestrial mammals contain a mixture of lipids, enriched in ceramides that are critical for the epidermal permeability barrier. Whereas glucosylceramides (GlcCer)
W M Holleran, Y Takagi, G K Menon, S M Jackson, J M Lee, K R Feingold, P M Elias   +6 more
doaj   +1 more source