Results 61 to 70 of about 92,135 (253)

Thematic review series: Skin Lipids. Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism

Journal of Lipid Research, 2008
Many of the ichthyoses are associated with inherited disorders of lipid metabolism. These disorders have provided unique models to dissect physiologic processes in normal epidermis and the pathophysiology of more common scaling conditions.
Peter M. Elias, Mary L. Williams, Walter M. Holleran, Yan J. Jiang, Matthias Schmuth   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Keratinocytes in Atopic Dermatitis — Their Pathogenic Involvement

Journal of Pharmacological Sciences, 2009
.: Atopic dermatitis frequently accompanies bronchial asthma, allergic rhinitis, and allergic conjunctivitis, the pathogenesis of which has frequently focused on the immunological aspects; however, skin eruption in atopic dermatitis occurs mainly in the ...
Mayumi Komine
doaj   +1 more source

Transdermal Drug Delivery in the Pig Skin

Pharmaceutics, 2021
Transdermal delivery can be accomplished through various mechanisms including formulation optimization, epidermal stratum corneum barrier disruption, or directly by removing the stratum corneum layer. Microneedling, electroporation, a combination of both
Ignacio Ordiz, José A. Vega, Raquel Martín-Sanz, Olivia García-Suárez, Miguel E. del Valle, Jorge Feito   +5 more
doaj   +1 more source

Crossing the Barrier: STRA6 in Epidermal Differentiation [PDF]

Journal of Investigative Dermatology, 2014
In this issue, Skazik et al. demonstrate that the STRA6 retinol transporter protein regulates the proliferation and differentiation of epidermal keratinocytes. In human organotypic three-dimensional skin and skin reconstitution models, depletion of STRA6 induced hyperproliferation-associated differentiation, resulting in epidermal expansion.
Laursen, Kristian B., Gudas, Lorraine J.
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Epidermal Skin Barrier

Asian Journal of Beauty and Cosmetology, 2016
표피의 각질형성세포가 세포분열과 분화를 거쳐 형성하는 각질층은 피부장벽의 핵심적인 조직이며 이러한 각질층의 형성과정에서 발생하는 불균형과 이상현상은 피부장벽의 기능 이상을 초래한다. 각질층의 기능을 조절하는 인자의 보다 상세한 이해를 위해, 본 논문은 피부장벽을 구성하는 각 요소를 자세히 서술해보았다. “Brick & Mortar” 모델에 따르면, 층판소체, 각질세포막, 지질, 칼슘, 사이토카인, 보습인자 등과 같은 피부장벽의 주된 요소가 자세히 묘사되어 있다. 각질층의 구조와 기능을 설명하는 가장 대표적인 모델은 “Brick & Mortar”로 설명되는 양분 모델이다.
Hyun Hee Jang, Sung Nae Lee
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Signaling roles of ceramide and its metabolites in cutaneous antimicrobial defense

Dermatologica Sinica, 2015
The skin epidermis is a multipurpose barrier (i.e., against epidermal permeability disruption and oxidative/UV irradiation) as well as a mechanical barrier and antimicrobial barrier, to protect cells/tissues from external perturbants.
Yoshikazu Uchida, Young il Kim, Kyungho Park   +2 more
doaj   +1 more source

Transcriptional Regulation of Epidermal Barrier Formation [PDF]

, 2011
The mammalian epidermis is a self-renewing stratified squamous epithelium. Its basal cell layer contains proliferating keratinocytes that exit the cell cycle when they move into the suprabasal compartment. These cells activate a gene differentiation program aimed at building a protective epidermal barrier as they move toward the surface, successively ...
Ambica, Bhandari, Michael L, Salmans, William, Gordon, Bogi, Andersen   +3 more
openaire   +2 more sources