Results 51 to 60 of about 2,098,761 (326)
The epidthelial sodium channel ENaC and its regulators in the epidermal permeability barrier function [PDF]
, 2010 The highly amiloride-sensitive epithelial sodium channel ENaC is well known to be involved in controlling whole body sodium homeostasis and lung liquid clearance. ENaC expression has also been detected in the skin of amphibians and mammals.
Charles, R-P. +2 more
core +1 more source
Active regulation of the epidermal calcium profile [PDF]
, 2012 A distinct calcium profile is strongly implicated in regulating the multi-layered structure of the epidermis. However, the mechanisms that govern the regulation of this calcium profile are currently unclear.
Adams, Matthew +2 more
core +2 more sources
The “Caveolae Brake Hypothesis” and the Epidermal Barrier [PDF]
Journal of Investigative Dermatology, 2009 Epidermal permeability barrier formation depends upon lamellar body (LB) secretion/fusion with the apical plasma membrane (APM) of outermost stratum granulosum (SG) cell, creating cholesterol/glycosphingolipid-enriched lipid rafts-like domains. We found that the dimensions of these domains are comparable to lipid raft in other cell types; and that ...
Roelandt, Truus +12 more
openaire +4 more sources
Psoriasis as a barrier disease
Dermatologica Sinica, 2015 Skin is equipped with a barrier function, in particular, to prevent invasion of pathogens. Skin barrier is composed of a mechanical barrier, a permeability barrier, and innate and adaptive immunity barriers.
Shigetoshi Sano
doaj +1 more source
Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]
, 2016 1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D +4 more
core +2 more sources
Xerosis: a Dysfunction of the Epidermal Barrier
Actas Dermo-Sifiliográficas (English Edition), 2008 Xerosis or dry skin is a common skin disorder among the general population. It is characterized clinically by rough, scaly, and often itchy skin. This disorder is present in the course of some dermatoses such as atopic dermatitis, although it can also occur in healthy individuals if a combination of certain etiologic factors is present.
D, Barco, A, Giménez-Arnau
openaire +2 more sources
Relationship of epidermal lipogenesis to cutaneous barrier function.
Journal of Lipid Research, 1987 Although the lipids of mammalian stratum corneum are known to be important for the cutaneous permeability barrier, the factors that regulate epidermal lipid biosynthesis are poorly understood.
G Grubauer, K R Feingold, P M Elias
doaj +1 more source
De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements.
Journal of Lipid Research, 1985 Recent studies suggest: that the epidermis and pilosebaceous epithelium are important sites of de novo sterol synthesis, and that the rate of cutaneous cholesterol synthesis does not change with alterations in circulating sterol levels.
G K Menon +4 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 Human β-defensin-3 (hBD-3) exhibits antimicrobial and immunomodulatory activities; however, its contribution to autophagy regulation remains unclear, and the role of autophagy in the regulation of the epidermal barrier in atopic dermatitis (AD) is poorly
Ge Peng +18 more
doaj +1 more source
Cytokine regulation of the epidermal barrier
Clinical & Experimental Allergy, 2013 Summary Studies published in recent years have highlighted the role of epidermal barrier defects in both atopic skin disease and the development of broader allergic manifestations. While genetic determinants of barrier function are important, it is clear that local acquired effects are also involved in disease pathogenesis.
Gutowska-Owsiak, D, Ogg, G
openaire +3 more sources