Results 21 to 30 of about 2,098,761 (326)

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Journal of the European Academy of Dermatology and Venereology, 2023
The stratum corneum (SC)—the outermost layer of the epidermis—is the principal permeability and protective barrier of the skin. Different components of the SC, including corneocytes, natural moisturizing factor, a variety of enzymes and their inhibitors,
J. W. Fluhr, D. Moore, Majella E Lane, Nadége Lachmann, A. V. Rawlings   +4 more
semanticscholar   +1 more source

SNPing at the Epidermal Barrier [PDF]

Journal of Investigative Dermatology, 2011
Filaggrin variants are well-established risk factors for atopic eczema (AE). Recent studies suggest additional epidermal differentiation complex (EDC) gene associations with AE. In this issue, Marenholz and colleagues confirm this prediction and show that a small proline-rich protein 3 (SPRR3) variant confers susceptibility to AE. This finding suggests
Kelsell, David P., Byrne, Carolyn
openaire   +2 more sources

Keratin 17 Is Required for Lipid Metabolism in Keratinocytes and Benefits Epidermal Permeability Barrier Homeostasis

Frontiers in Cell and Developmental Biology, 2022
The epidermal barrier refers to the stratum corneum, the uppermost layer of the skin, and constitutes the first line of defense against invasion by potentially harmful pathogens, diminishes trans-epidermal water loss, and plays a crucial role in the ...
Bingyu Pang, Zhenlai Zhu, Chunying Xiao, Yixin Luo, Hui Fang, Yaxing Bai, Zhongbin Sun, Jingyi Ma, Erle Dang, Gang Wang   +9 more
doaj   +1 more source

sPLA2 and the epidermal barrier [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
The mammalian epidermis provides both an interface and a protective barrier between the organism and its environment. Lipid, processed into water-impermeable bilayers between the outermost layers of the epidermal cells, forms the major barrier that prevents water from exiting the organism, and also prevents toxins and infectious agents from entering ...
Ilic, Dusko, Bollinger, James M, Gelb, Michael, Mauro, Theodora M   +3 more
openaire   +5 more sources

The Effect of Intense Pulsed Light on the Skin Microbiota and Epidermal Barrier in Patients with Mild to Moderate Acne Vulgaris

Lasers in Surgery and Medicine, 2021
The skin microbiota partly determined by epidermal barrier plays an important role in acne vulgaris and intense pulsed light (IPL) has been verified as a safe and effective therapeutic option for this disease.
Jiexiong Liu, Lu Liu, Lin Zhou, Lingna Chen, Xia Chen, X. Xiong, Yongqiong Deng   +6 more
semanticscholar   +1 more source

Deimination in epidermal barrier and hair formation. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Peptidylarginine deiminases (PADs) transform a protein arginine residue into the non-standard amino acid citrulline. This calcium-dependent post-translational modification of proteins is called citrullination or deimination. As described in this special issue, PADs play a role in various physiological processes, and PAD deregulations are ...
Méchin MC, Simon M.
europepmc   +3 more sources

Commensal Cutibacterium acnes induce epidermal lipid synthesis important for skin barrier function

Science Advances, 2023
Lipid synthesis is necessary for formation of epithelial barriers and homeostasis with external microbes. An analysis of the response of human keratinocytes to several different commensal bacteria on the skin revealed that Cutibacterium acnes induced a ...
Samia Almoughrabie, L. Cau, Kellen J. Cavagnero, A. O’Neill, Fengwu Li, Andrea Roso-Mares, C. Mainzer, B. Closs, Matthew J. Kolar, Kevin J. Williams, S. Bensinger, R. Gallo   +11 more
semanticscholar   +1 more source

The Epidermal Barrier Structure and Function of Re-Harvested Skin from Non-Scalp Donor Sites

Journal of Investigative Surgery, 2023
Aim The aim of this study was to explore the epidermal barrier structure and function of re-harvested skin from non-scalp donor sites. Methods Six patients with large-area deep burns who met the inclusion and exclusion criteria were subjected to split ...
Bohan Zhang, Peng Luo, Jiachen Sun, Dawei Li, Zhaoxing Liu, Xinzhu Liu, Hongqing Zhao, Zhisheng Li, Xiaoye Xie, Jianqiu Yang, Chuan’an Shen   +10 more
doaj   +1 more source

Staphylococcus aureus causes aberrant epidermal lipid composition and skin barrier dysfunction

Allergy. European Journal of Allergy and Clinical Immunology, 2023
Staphylococcus (S) aureus colonization is known to cause skin barrier disruption in atopic dermatitis (AD) patients. However, it has not been studied how S. aureus induces aberrant epidermal lipid composition and skin barrier dysfunction.
Jihyun Kim, B. Kim, E. Berdyshev, Irina A. Bronova, L. Bin, Jaewoong Bae, Seokjin Kim, Hye-Young Kim, U. Lee, M. Kim, Hyunmi Kim, Jinyoung Lee, C. Hall, Jessica W Hui-Beckman, Yunhee Chang, A. Bronoff, Dasom Hwang, Hae-Young Lee, E. Goleva, K. Ahn, D. Leung   +20 more
semanticscholar   +1 more source

Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes [PDF]

, 2020
Fibroblast growth factors (FGFs) are key regulators of tissue development, homeostasis and repair, and abnormal FGF signalling is associated with various human diseases.
Ben-Yehuda Greenwald, Maya, Chen, Lin, Iizuka, Haruka, Jukic, Marko, Kubo, Fumimasa, Meyer, Michael, Ornitz, David M, Rauschendorfer, Theresa, Sänger, Catharina, Werner, Sabine   +9 more
core   +2 more sources