Results 11 to 20 of about 92,135 (253)

SNPing at the Epidermal Barrier [PDF]

open access: yesJournal of Investigative Dermatology, 2011
Filaggrin variants are well-established risk factors for atopic eczema (AE). Recent studies suggest additional epidermal differentiation complex (EDC) gene associations with AE. In this issue, Marenholz and colleagues confirm this prediction and show that a small proline-rich protein 3 (SPRR3) variant confers susceptibility to AE. This finding suggests
Kelsell, David P., Byrne, Carolyn
openaire   +2 more sources

Keratin 17 Is Required for Lipid Metabolism in Keratinocytes and Benefits Epidermal Permeability Barrier Homeostasis

open access: yesFrontiers in Cell and Developmental Biology, 2022
The epidermal barrier refers to the stratum corneum, the uppermost layer of the skin, and constitutes the first line of defense against invasion by potentially harmful pathogens, diminishes trans-epidermal water loss, and plays a crucial role in the ...
Bingyu Pang   +9 more
doaj   +1 more source

sPLA2 and the epidermal barrier [PDF]

open access: yesBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
The mammalian epidermis provides both an interface and a protective barrier between the organism and its environment. Lipid, processed into water-impermeable bilayers between the outermost layers of the epidermal cells, forms the major barrier that prevents water from exiting the organism, and also prevents toxins and infectious agents from entering ...
Ilic, Dusko   +3 more
openaire   +5 more sources

Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices. [PDF]

open access: yesPLoS ONE, 2017
Full thickness human skin models (FTMs) contain an epidermal and a dermal equivalent. The latter is composed of a collagen dermal matrix which harbours fibroblasts.
Arnout Mieremet   +5 more
doaj   +1 more source

The Epidermal Barrier Structure and Function of Re-Harvested Skin from Non-Scalp Donor Sites

open access: yesJournal of Investigative Surgery, 2023
Aim The aim of this study was to explore the epidermal barrier structure and function of re-harvested skin from non-scalp donor sites. Methods Six patients with large-area deep burns who met the inclusion and exclusion criteria were subjected to split ...
Bohan Zhang   +10 more
doaj   +1 more source

Herbal medicines that benefit epidermal permeability barrier function

open access: yesDermatologica Sinica, 2015
Epidermal permeability barrier function plays a critical role in regulating cutaneous functions. Hence, researchers have been searching for effective and affordable regimens to enhance epidermal permeability barrier function.
Lizhi Hu   +3 more
doaj   +1 more source

Role of mTOR Signaling Cascade in Epidermal Morphogenesis and Skin Barrier Formation

open access: yesBiology, 2022
The skin epidermis, with its capacity for lifelong self-renewal and rapid repairing response upon injury, must maintain an active status in metabolism.
Juan Wang, Sabine A. Eming, Xiaolei Ding
doaj   +1 more source

Epidermal Barriers [PDF]

open access: yesCold Spring Harbor Perspectives in Medicine, 2014
The epidermis functions as a physical barrier to the external environment and works to prevent loss of water from the skin. Numerous factors have been implicated in the formation of epidermal barriers, such as cornified envelopes, corneocytes, lipids, junctional proteins, proteases, protease inhibitors, antimicrobial peptides, and transcription factors.
openaire   +2 more sources

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