Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices. [PDF]
PLoS ONE, 2017 Full thickness human skin models (FTMs) contain an epidermal and a dermal equivalent. The latter is composed of a collagen dermal matrix which harbours fibroblasts.
Arnout Mieremet +5 more
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Comparison of Epidermal Barrier Integrity in Adults with Classic Atopic Dermatitis, Atopic Prurigo and Non-Atopic Prurigo Nodularis [PDF]
Biology, 2021 A deficient epidermal barrier is a key feature of atopic dermatitis (AD) and comprises altered lipid and protein content and composition of the stratum corneum resulting in disturbed water balance.
Regina Fölster-Holst +9 more
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Umbelliferone preserves skin epidermal barrier integrity in diabetes-induced keratinocytes by regulating actin dynamics and suppressing ROS-mediated apoptosis [PDF]
Nutrition & DiabetesBackground The skin serves as a fundamental protective barrier against environmental insults, with the epidermis, particularly the stratum corneum and tight junctions (TJs) connecting keratinocytes, playing a crucial role.
Dong Yeon Kim +2 more
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The 4E-BP1 deletion modestly mitigates mTORC1-deficient epidermal barrier defects [PDF]
JID InnovationsmTOR signaling is essential for epidermal development, yet the downstream mechanisms mediating its effects remain unclear. The 4E-BP1 (eukaryotic initiation factor 4E-binding protein 1), a major mTORC1 target that inhibits cap-dependent translation, has ...
Huihao Tang +7 more
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β-endorphin suppresses ultraviolet B irradiation-induced epidermal barrier damage by regulating inflammation-dependent mTORC1 signaling [PDF]
Scientific Reports, 2023 Solar ultraviolet B (UVB) radiation triggers excessive inflammation, disrupting the epidermal barrier, and can eventually cause skin cancer. A previous study reported that under UVB irradiation, epidermal keratinocytes synthesize the proopiomelanocortin ...
Hyung-Su Kim +4 more
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Bioconversion of BIOGF1K, a compound-K-rich fraction from ginseng root and its effect on epidermal barrier function [PDF]
Heliyon, 2023 BIOGF1K, the ginseng root-based and hydrolyzed ginsenoside-rich fraction, is known to improve skin damage, but there are rare studies on the kinetic of ginsenosides in the epidermis and their effects on epidermal barrier function.
Woo-Hyun Kim +7 more
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Epidermal Hyaluronan in Barrier Alteration-Related Disease
Cells, 2021 In skin, although the extracellular matrix (ECM) is highly developed in dermis and hypodermis, discrete intercellular spaces between cells of the living epidermal layers are also filled with ECM components.
Céline Evrard +2 more
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Marine Drugs, 2019 The epidermal barrier acts as a line of defense against external agents as well as helps to maintain body homeostasis. The calcium concentration gradient across the epidermal barrier is closely related to the proliferation and differentiation of ...
Wengang Zhao, Nuo Xu, Zhenlin Hu
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Light repair effect of polysaccharides component from white Ganoderma lucidum and Laminaria japonica fermentation broth attenuates epidermal barrier dysfunction via TRPV4-Keap-1/Nrf2 pathway [PDF]
Bioresources and BioprocessingEpidermal photoinflammation has emerged as an atypical pathological response that poses a growing global threat to human health and well-being. In this study, a polysaccharide component (named LJGp) was isolated from Laminaria japonica and white ...
Xinrui Jiang +8 more
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Epidermal Barrier Development via Corneoptosis: A Unique Form of Cell Death in Stratum Granulosum Cells [PDF]
Journal of Developmental Biology, 2023 Takeshi Matsui
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