Results 1 to 10 of about 9,136 (192)

Filaggrin – revisited [PDF]

International Journal of Cosmetic Science, 2013
SynopsisProfilaggrin (proFLG) and its processing products are critical to the health and appearance of skin. The recent identification of loss‐of‐function filaggrin (FLG) mutations as a predisposing factor in ichthyosis vulgaris and atopic dermatitis has lead to a resurgent interest in this enigmatic protein.
C R, Harding, S, Aho, C A, Bosko
exaly   +3 more sources

Remodeling of the cell membrane-associated protein pool affects adhesive membrane properties in filaggrin insufficient keratinocytes and impacts distinct cellular and organellar functions [PDF]

BMC Biology
Background Atopic dermatitis (AD) is a highly prevalent inflammatory skin disease, affecting up to 30% of children at some point in their life and frequently persisting into adulthood.
Adrian Kobiela, Mikołaj Klimczuk, Paweł Kamil Serafin, Kamila Kitowska, Anna Biernacka, Reza Abouali, Jorge Bernardino de la Serna, Xinwen Wang, Felicja Gajdowska, Aniela Kosobucka, Aleksandra Małgorzata Siedlar, Amandine Hauer, Lilit Hovhannisyan, Aleksandra Bogucka, Jos P. H. Smits, Ellen H. van den Bogaard, Rafał Sądej, Graham S. Ogg, Danuta Gutowska-Owsiak   +18 more
doaj   +2 more sources

Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis [PDF]

Experimental and Molecular Medicine, 2005
Filaggrin is expressed in the cornified layer of epidermis and known to be one of the antigenic targets in rheumatoid arthritis. Although the citrulline residue in filaggrin is thought to be an antigenic determinant recognized by autoantibodies, the diagnostic sensitivity of synthetic citrullinated peptide is variable. To investigate the implication of
Chai-Wan Kim, Ju-Hong Jeon, In Gyu Kim
exaly   +3 more sources

FilaggrinHigh melanomas exhibit active FGFR and allergic signatures with impaired GNA14 and Th1 signatures [PDF]

Frontiers in Genetics
Filaggrin gene (FLG/FLG2) product deregulations are associated with various allergic skin diseases, including but not limited to atopic dermatitis, alopecia areata, and ichthyosis vulgaris.
Goodwin G. Jinesh, Goodwin G. Jinesh, Isha Godwin   +2 more
doaj   +2 more sources

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response [PDF]

Brazilian Journal of Medical and Biological Research, 2014
The objective of this study was to investigate whether a single defect in skin barrier function simulated by filaggrin silencing could induce Th2-predominant inflammation.
N.N. Dang, S.G. Pang, H.Y. Song, L.G. An, X.L. Ma   +4 more
doaj   +3 more sources

The Discovery and Function of Filaggrin [PDF]

International Journal of Molecular Sciences, 2022
Keratohyalin granules were discovered in the mid-19th century in cells that terminally differentiate to form the outer, cornified layer of the epidermis. The first indications of the composition of these structures emerged in the 1960s from a histochemical stain for histidine, followed by radioautographic evidence of a high incidence of histidine ...
J. Kenneth Hoober, Laura L. Eggink
openaire   +2 more sources

Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2‐dependent fashion

Journal of Extracellular Vesicles, 2023
Filaggrin (FLG) protein is indispensable for multiple aspects of the epidermal barrier function but its accumulation in a monomeric filaggrin form may initiate premature keratinocytes death; it is unclear how filaggrin levels are controlled before the ...
Adrian Kobiela, Lilit Hovhannisyan, Paulina Jurkowska, Jorge Bernardino dela Serna, Aleksandra Bogucka, Milena Deptuła, Argho Aninda Paul, Kinga Panek, Ewa Czechowska, Michał Rychłowski, Aleksandra Królicka, Jacek Zieliński, Susanne Gabrielsson, Michał Pikuła, Magdalena Trzeciak, Graham S Ogg, Danuta Gutowska‐Owsiak   +16 more
doaj   +1 more source

The Pathogenesis of Eosinophilic Asthma: A Positive Feedback Mechanism That Promotes Th2 Immune Response via Filaggrin Deficiency

Frontiers in Immunology, 2021
Eosinophilic asthma (EA) is a common subtype of asthma and often progresses to severe disease. In order to understand its pathogenesis, targeted next-generation gene sequencing was performed on 77 Chinese EA patients and 431 Chinese healthy controls to ...
Wei Gao, Jiuyu Gong, Mi Mu, Yujin Zhu, Yujin Zhu, Wenjuan Wang, Wen Chen, Guojing Han, Hong Hu, Pengtao Bao   +9 more
doaj   +1 more source

Analysis of filaggrin 2 gene polymorphisms in patients with atopic dermatitis, [PDF]

Anais Brasileiros de Dermatologia, 2020
Background: Polymorphisms of the filaggrin 2 gene (rs 12568784 and rs 16899374) are associated with persistent atopic dermatitis in African American patients. Filaggrin 2 is a protein with a function similar to filaggrin and also encoded in the epidermal
Amanda Hertz, Luna Azulay-Abulafia, Adriana Paulino do Nascimento, Cintya Yumi Ohara, Fabio Chigres Kuschnir, Luís Cristovão Porto   +5 more
doaj   +1 more source

Update on canine filaggrin: a review [PDF]

Veterinary Quarterly, 2020
Human filaggrin (FLG) plays a key role in epidermal barrier function, and loss-of-function mutations of its gene are primarily responsible for the development of human atopic dermatitis (AD). FLG expression is also reduced in the epidermis of atopic patients, due to the transcriptional effect of Th2 type cytokines.
Combarros, Daniel, Cadiergues, Marie-Christine, Simon, Michel   +2 more
openaire   +3 more sources