Results 21 to 30 of about 17,224 (237)

Increased Production of IL-17A-Producing γδ T Cells in the Thymus of Filaggrin-Deficient Mice

Frontiers in Immunology, 2018
Mutations in the filaggrin gene (Flg) are associated with increased systemic levels of Th17 cells and increased IL-17A production following antigen exposure in both humans and mice. In addition to Th17 cells, γδ T cells can produce IL-17A.
Mia Hamilton Jee, Mia Hamilton Jee, Jeanne Duus Johansen, Terkild Brink Buus, Trine Hilkjær Petersen, Anne-Sofie Østergaard Gadsbøll, Anders Woetmann, Niels Ødum, Jacob Pontoppidan Thyssen, Andrea Jane White, Graham Anderson, Carsten Geisler, Charlotte Menné Bonefeld   +12 more
doaj   +1 more source

Recombinant Filaggrin Is Internalized and Processed to Correct Filaggrin Deficiency [PDF]

Journal of Investigative Dermatology, 2014
This study was designed to engineer a functional filaggrin (FLG) monomer linked to a cell-penetrating peptide (RMR) and to test the ability of this peptide to penetrate epidermal tissue as a therapeutic strategy for genetically determined atopic dermatitis (AD). A single repeat of the murine filaggrin gene (Flg) was covalently linked to a RMR motif and
Stout, Thomas E., McFarland, Trevor, Mitchell, John C., Appukuttan, Binoy, Timothy Stout, J.   +4 more
openaire   +2 more sources

Filaggrin and cytokines in respiratory samples of preterm infants at risk for respiratory viral infection

Scientific Reports, 2022
Respiratory viral infections (RVIs) are frequent in preterm infants possibly inducing long-term impact on respiratory morbidity. Immune response and respiratory barriers are key defense elements against viral insults in premature infants admitted to ...
José M. Rodrigo-Muñoz, Beatriz Sastre, Laura Sánchez-García, María Luz García-García, Ersilia Gonzalez-Carrasco, Celia Fabra, Marta Gil-Martínez, Clara Lorente-Sorolla, Raquel García-Latorre, Sonia Alcolea, Inmaculada Casas, Cristina Calvo, Victoria del Pozo   +12 more
doaj   +1 more source

Filaggrin Defect at Atopic Dermatitis: Modern Treatment Options

Вопросы современной педиатрии, 2022
Atopic dermatitis is a common chronic skin disease, its pathogenesis is associated with congenital or acquired deficiency of filaggrin protein. In recent years, extensive evidence on the causes of filaggrin deficiency has been obtained. The structure and
Nikolay N. Murashkin, Leonid A. Opryatin, Roman V. Epishev, Alexander I. Materikin, Eduard T. Ambarchian, Roman A. Ivanov, Alena A. Savelova, Roza Y. Nezhvedilova, Lyudmila L. Rusakova   +8 more
doaj   +1 more source

The Pathogenesis of Atopic Dermatitis: The Role of Filaggrin

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2017
Background: Atopic dermatitis (AD) is a multifactorial skin disease with waxing and waning inflammatory process. In recent years, genetic mutations namely the null mutations of the filaggrin gene (FLG) has been the focus in AD risk factors investigations.
Tamarachiara Kuntjoro, Erna Harijati
doaj   +1 more source

The time-dependent expression of keratins 5 and 13 during the reepithelialization of human skin wounds [PDF]

, 1993
The time-dependent reepithelialization of 55 human surgical skin wounds with a wound age between 8h and more than 2 months was investigated by the immunohistochemical localization of cytokeratins 5 and 13.
A. Nerlich, D Cooper, D Cooper, D Mischke, EJ O'Keefe, G Gabbiani, GD Winter, GNP Muijen van, J-P Ortonne, J. Tübel, JL Cordell, JN Mansbridge, LJ Ordman, M Guo, P Betz, P. Betz, R Moll, R Moll, R. Penning, RAF Clark, SC Pang, SM Hsu, SV Pollack, TT Sun, W Oehlert, W. Eisenmenger   +25 more
core   +1 more source

Edible bird’s nest, an Asian health food supplement, possesses anti-inflammatory responses in restoring the symptoms of atopic dermatitis: An analysis of signaling cascades

Frontiers in Pharmacology, 2022
Edible bird’s nest (EBN) is a Chinese delicacy possessing skin rejuvenating functions. To verify skin anti-inflammatory function of EBN, water extract and enzymatic digest of EBN, as well as the major sialic acid, N-acetyl neuraminic acid (NANA), were ...
Queenie Wing Sze Lai, Queenie Wing Sze Lai, Qunyan Fan, Brody Zhongyu Zheng, Brody Zhongyu Zheng, Yanxian Chen, Yanxian Chen, Tina Tingxia Dong, Tina Tingxia Dong, Karl Wah Keung Tsim, Karl Wah Keung Tsim   +10 more
doaj   +1 more source

Orchestrated control of filaggrin-actin scaffolds underpins cornification. [PDF]

, 2018
Epidermal stratification critically depends on keratinocyte differentiation and programmed death by cornification, leading to formation of a protective skin barrier.
Bernardino de la Serna, Jorge, Colin-York, Huw, Eggeling, Christian, Fritzsche, Marco, Gutowska-Owsiak, Danuta, Leeming, Michael, Naeem, Aishath, Ogg, Graham, O’Shaughnessy, Ryan, Podobas, Ewa Izabela   +9 more
core   +6 more sources

Evolutionary origin and diversification of epidermal barrier proteins in amniotes. [PDF]

, 2014
The evolution of amniotes has involved major molecular innovations in the epidermis. In particular, distinct structural proteins that undergo covalent cross-linking during cornification of keratinocytes facilitate the formation of mechanically resilient ...
Alibardi, Lorenzo, Eckhart, Leopold, Eigenheer, Richard A, Hermann, Marcela, Mlitz, Veronika, Rice, Robert H, Strasser, Bettina, Tschachler, Erwin   +7 more
core   +1 more source

Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families [PDF]

, 2008
Recent studies have identified 2 loss-of-function variants, R501X and 2282del4, in the filaggrin gene as predisposing factors in the development of eczema.
Bradley, Maria, D'Amato, Mauro, Ekelund, Elisabeth, Kockum, Ingrid, Lee, Simon P., Lieden, Agne, Link, Jenny, Palmer, Colin N. A.   +7 more
core   +3 more sources