Results 21 to 30 of about 9,136 (192)

One Remarkable Molecule: Filaggrin [PDF]

Journal of Investigative Dermatology, 2012
The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the cause of ichthyosis vulgaris-the most common disorder of keratinization-and also a strong genetic risk factor for atopic eczema, marked a significant breakthrough in the understanding of eczema pathogenesis.
Brown, Sara J., McLean, W. H. Irwin
openaire   +3 more sources

Edible bird’s nest, an Asian health food supplement, possesses anti-inflammatory responses in restoring the symptoms of atopic dermatitis: An analysis of signaling cascades

Frontiers in Pharmacology, 2022
Edible bird’s nest (EBN) is a Chinese delicacy possessing skin rejuvenating functions. To verify skin anti-inflammatory function of EBN, water extract and enzymatic digest of EBN, as well as the major sialic acid, N-acetyl neuraminic acid (NANA), were ...
Queenie Wing Sze Lai, Queenie Wing Sze Lai, Qunyan Fan, Brody Zhongyu Zheng, Brody Zhongyu Zheng, Yanxian Chen, Yanxian Chen, Tina Tingxia Dong, Tina Tingxia Dong, Karl Wah Keung Tsim, Karl Wah Keung Tsim   +10 more
doaj   +1 more source

New Functions of Low-Molecular-Weight Hyaluronic Acid on Epidermis Filaggrin Production and Degradation

Cosmetics, 2021
Hyaluronic acid (HA) is a high-molecular-weight polysaccharide with high moisturizing power. It is composed of repeating disaccharides of N-acetyl-D-glucosamine and D-glucuronic acid.
Moe Hashimoto, Kazuhisa Maeda
doaj   +1 more source

A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study

BMJ Open, 2011
Background Filaggrin proteins are located in the skin and prevent epidermal water loss and impede the entry of micro-organisms, allergens and chemicals.
Allan Linneberg, Torben Hansen, Jacob P Thyssen, Steen Stender, Oluf Pedersen, Berit C Carlsen, Jeanne D Johansen, Kåre Engkilde, Flemming Pociot, Michael Meldgaard, Pal B Szecsi, Torkil Menné   +11 more
doaj   +1 more source

Studies Using Antibodies against Filaggrin and Filaggrin 2 in Canine Normal and Atopic Skin Biopsies

Animals
Filaggrin is important for the skin barrier and atopic dermatitis. Another filaggrin-like protein, filaggrin 2, has been described. We evaluated antibodies against both filaggrins in normal and atopic skin biopsies from dogs before and after allergen ...
Rosanna Marsella, Kim Ahrens, Rachel Wilkes   +2 more
doaj   +1 more source

Role of Filaggrin in Pediatric Allergology

Zdorovʹe Rebenka, 2013
There had been found strong evidence that a violation of the epidermal barrier is a necessary condition for the development of sensitivity to allergens.
A.P. Volosovets, S.P. Krivopustov, Ye.V. Pavlik   +2 more
doaj   +1 more source

In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers

Frontiers in Molecular Biosciences, 2023
Background: Loss of function mutation in FLG is the major genetic risk factor for atopic dermatitis (AD) and other allergic manifestations. Presently, little is known about the cellular turnover and stability of profilaggrin, the protein encoded by FLG ...
Argho Aninda Paul, Natalia A. Szulc, Adrian Kobiela, Sara J. Brown, Wojciech Pokrzywa, Danuta Gutowska-Owsiak   +5 more
doaj   +1 more source

Functional Significance of Single-Nucleotide Polymorphism (rs11204981) in Filaggrin (flg) Gene for the Treatment of Bronchial Asthma in Children with Atopic Dermatitis

Zdorovʹe Rebenka, 2015
Objective. The objective of this study was to determine the correlation between single-nucleotide polymorphism in filaggrin gene and expression of filaggrin mRNA in buccal epithelium and the phenotype of bronchial asthma with atopic dermatitis in medical
O.P. Volosovets, V.Ye. Dosenko, S.P. Kryvopustov, O.V. Pavlyk, O.V. Yemets, D.O. Stroi   +5 more
doaj   +1 more source

The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update

Frontiers in Molecular Biosciences, 2023
Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disease with various clinical presentations and combinations of symptoms. The pathophysiology of AD is complex and multifactorial.
Tubanur Çetinarslan, Lisa Kümper, Regina Fölster-Holst   +2 more
doaj   +1 more source

Real-time PCR quantification of the canine filaggrin orthologue in the skin of atopic and non-atopic dogs: a pilot study

BMC Research Notes, 2011
Background Canine atopic dermatitis (AD) is a common inflammatory skin disease associated with defects in the epidermal barrier, particularly in West Highland white terriers (WHWTs).
Roque Joana, O'Leary Caroline A, Kyaw-Tanner Myat, Duffy David L, Shipstone Michael   +4 more
doaj   +1 more source