Results 11 to 20 of about 17,224 (237)

Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.

PLoS ONE, 2020
Skin aspartic acid protease (SASPase) is believed to be a key enzyme involved in filaggrin processing during epidermal terminal differentiation. Since little is known about the regulation of SASPase function, the aim of this study was to identify ...
Mark Donovan, Mélanie Salamito, Agnès Thomas-Collignon, Lucie Simonetti, Stephanie Desbouis, Jean-Christophe Rain, Etienne Formstecher, Dominique Bernard   +7 more
doaj   +4 more sources

Filaggrin – revisited [PDF]

International Journal of Cosmetic Science, 2013
SynopsisProfilaggrin (proFLG) and its processing products are critical to the health and appearance of skin. The recent identification of loss‐of‐function filaggrin (FLG) mutations as a predisposing factor in ichthyosis vulgaris and atopic dermatitis has lead to a resurgent interest in this enigmatic protein.
C R, Harding, S, Aho, C A, Bosko
openaire   +2 more sources

Update on canine filaggrin: a review [PDF]

Veterinary Quarterly, 2020
Human filaggrin (FLG) plays a key role in epidermal barrier function, and loss-of-function mutations of its gene are primarily responsible for the development of human atopic dermatitis (AD). FLG expression is also reduced in the epidermis of atopic patients, due to the transcriptional effect of Th2 type cytokines.
Combarros, Daniel, Cadiergues, Marie-Christine, Simon, Michel   +2 more
openaire   +3 more sources

One Remarkable Molecule: Filaggrin [PDF]

Journal of Investigative Dermatology, 2012
The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the cause of ichthyosis vulgaris-the most common disorder of keratinization-and also a strong genetic risk factor for atopic eczema, marked a significant breakthrough in the understanding of eczema pathogenesis.
Brown, Sara J., McLean, W. H. Irwin
openaire   +3 more sources

Cutaneous Deficiency of Filaggrin and STAT3 Exacerbates Vaccinia Disease In Vivo. [PDF]

PLoS ONE, 2017
Defects in filaggrin and STAT3 are associated with atopic dermatitis (AD) and susceptibility to severe skin infection.We evaluated skin infection with the current smallpox vaccine, ACAM-2000, in immunosuppressed mice with combined cutaneous deficiency in
Yong He, Ishrat Sultana, Kazuyo Takeda, Jennifer L Reed   +3 more
doaj   +1 more source

Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: A pivotal interplay in the pathogenesis of Atopic Dermatitis [PDF]

, 2018
Individuals with Atopic dermatitis (AD) are highly susceptible to Staphylococcus aureus colonization. However, the mechanisms driving this process as well as the impact of S. aureus in AD pathogenesis are still incompletely understood.
A Matlow, A Oliveira de, A Sandilands, A Sonesson, AC Krakowski, AD Irvine, AM Bowcock, B Cabanillas, B Han, BC Friedman, C Fux, C Pascolini, CI Ewing, CL Jinnestal, D Ellinghaus, D Lebeaux, DY Koller, DYM Leung, DYM Leung, E Clark, E Weinberg, EC Clark, EG Domenico Di, EG Domenico Di, FJ Bath-Hextall, FR Menegotto, G Stinco, GF Gad, GL Hazelbauer, GM O’Regan, GM O’Regan, GU Meduri, H Akiyama, HB Allen, HH Kong, I Marenholz, I Nomura, J Oh, J Schmitt, JH Lee, JM Hanifin, JQ Gong, K Becker, K Breuer, K Krause, KL Hon, L Chronopoulou, L Paternoster, LA O’Neill, LP Girard, M Bhattacharya, M Denis, M Mehrotra, M Niebuhr, MD Howell, ML Schuttelaar, MS Haque, P Castaneda, P Chavant, PH Hoeger, R Lever, R Saginur, RA McLaughlin, RL Gallo, RM Klevens, RP Howlin, S Eriksson, S Kanangat, S Kezic, S Kezic, S Stutte, S Weidinger, SE Hill, SE Satorres, SE Satorres, SH Cho, SH Hung, SJ Gilani, SX Xu, T Bieber, T Biedermann, T Kobayashi, T Nakatsuji, T Werfel, TX Nhan, UG Meduri, V Dossow von, W Abramovits, Z Ikezawa   +88 more
core   +1 more source

Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract

Veterinary Sciences, 2022
Filaggrin is an epidermal protein involved in skin barrier formation and hydration, whose expression is altered in canine atopic dermatitis (CAD). CAD patients also present an abnormal immune response with an altered expression of antimicrobial peptides (
Sergi Segarra, Tanesha Naiken, Julien Garnier, Valérie Hamon, Nathalie Coussay, François-Xavier Bernard   +5 more
doaj   +1 more source

Citrullination – small change with a great consequence [PDF]

, 2013
Citrullination is one of the possible post-translational modifications of proteins. It is based on a conversion of L-arginine residue (L-Arg) to L-citrulline residue (L-Cit). The reaction is catalyzed by peptidylarginine deiminases (PAD). The change of L-
Gogól Mariusz
core   +2 more sources

Fos co-operation with PTEN loss elicits keratoacanthoma not carcinoma due to p53/p21^WAF-induced differentiation triggered by GSK3b inactivation and reduced AKT activity [PDF]

, 2008
To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate PTEN function [K14.cre/D5PTENflx] in mouse epidermis expressing activated v-fos [HK1.fos].
Alexander, C.L., Chan, W-C., Greenhalgh, D.A., Quinn, J., Wu, H., Yao, D.   +5 more
core   +1 more source

Filaggrin and atopic march [PDF]

Biochemia medica, 2019
There is an increasing number of experimental, genetic and clinical evidence of atopic dermatitis expression as a pre-condition for later development of other atopic diseases such as asthma, food allergy and allergic rhinitis. Atopic dermatitis is a heterogeneous, recurrent childhood disease, also present in the adult age. It is increasingly attributed
Čepelak, Ivana, Dodig, Slavica, Pavić, Ivan   +2 more
openaire   +5 more sources