Results 41 to 50 of about 17,224 (237)

Role of genetic aspect in pathogenesis of atopic dermatitis [PDF]

, 2013
The pathogenesis of atopic dermatitis (AD) is a very complicated process that involves an intricate array of molecules. Nowadays it is generally accepted that cytokines play an important role in the progression of the clinical presentation of atopic ...
Wesserling Martyna
core   +2 more sources

The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update

Frontiers in Molecular Biosciences, 2023
Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disease with various clinical presentations and combinations of symptoms. The pathophysiology of AD is complex and multifactorial.
Tubanur Çetinarslan, Lisa Kümper, Regina Fölster-Holst   +2 more
doaj   +1 more source

Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. [PDF]

, 2012
Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), NAD(+)-dependent enzymes, link cellular energy status with responses to environmental stresses.
Benavente, Claudia A, Jacobson, Elaine L, Schnell, Stephanie A   +2 more
core   +3 more sources

Functional Significance of Single-Nucleotide Polymorphism (rs11204981) in Filaggrin (flg) Gene for the Treatment of Bronchial Asthma in Children with Atopic Dermatitis

Zdorovʹe Rebenka, 2015
Objective. The objective of this study was to determine the correlation between single-nucleotide polymorphism in filaggrin gene and expression of filaggrin mRNA in buccal epithelium and the phenotype of bronchial asthma with atopic dermatitis in medical
O.P. Volosovets, V.Ye. Dosenko, S.P. Kryvopustov, O.V. Pavlyk, O.V. Yemets, D.O. Stroi   +5 more
doaj   +1 more source

Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences

Frontiers in Molecular Biosciences, 2022
Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel.
Ewa Izabela Podobas, Ewa Izabela Podobas, Ewa Izabela Podobas, Danuta Gutowska-Owsiak, Danuta Gutowska-Owsiak, Sébastien Moretti, Jarosław Poznański, Mariusz Kulińczak, Marcin Grynberg, Aleksandra Gruca, Arkadiusz Bonna, Dawid Płonka, Tomasz Frączyk, Graham Ogg, Wojciech Bal   +14 more
doaj   +1 more source

Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity:Implications for atopic dermatitis [PDF]

, 2018
Background: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products [natural moisturizing factors (NMFs ...
Barrett, Bartnikas, Breternitz, Brough, Brown, Carson, Chittock, Clements, Dapic, DeLapp, Fallon, Fluhr, Gibbs, Halkjaer, Hoath, Horimukai, Hsu, Irvine, Kamata, Kamata, Kashibuchi, Kelleher, Kennedy, Kuroda, Ludriksone, McAleer, Mohammed, Mohammed, Raj, Raj, Rawlings, Sandilands, Sandilands, Schwartz, Scott, Simpson, Stamatas, Stamatas, Strid, Strid, Tagami, Takahashi, Takeda, Takeda, Visscher, Voegeli, Voegeli, Weidinger, Yamamoto, Yamazaki   +49 more
core   +3 more sources

Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis [PDF]

Experimental & Molecular Medicine, 2005
Filaggrin is expressed in the cornified layer of epidermis and known to be one of the antigenic targets in rheumatoid arthritis. Although the citrulline residue in filaggrin is thought to be an antigenic determinant recognized by autoantibodies, the diagnostic sensitivity of synthetic citrullinated peptide is variable. To investigate the implication of
Kyung Ho, Choi, Eun Bong, Lee, Chang Dal, Yoo, Han Joo, Baek, Seong Wook, Kang, Ki Chul, Shin, Yun Jong, Lee, Hyun Ah, Kim, Ju Hong, Jeon, Chai Wan, Kim, Dong Myung, Shin, In Gyu, Kim, Yeong Wook, Son   +12 more
openaire   +2 more sources

Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort.

PLoS ONE, 2009
BackgroundFilaggrin is a major protein in the epidermis. Several mutations in the filaggrin gene (FLG) have been associated with a number of conditions.
Santiago Rodriguez, Amanda J Hall, Raquel Granell, W H Irwin McLean, Alan D Irvine, Colin N A Palmer, George Davey Smith, John Henderson, Ian N M Day   +8 more
doaj   +1 more source

The Suppressive Effect of Leucine-Rich Glioma Inactivated 3 (LGI3) Peptide on Impaired Skin Barrier Function in a Murine Model Atopic Dermatitis

Pharmaceutics, 2020
This study aimed to restore the skin barrier function from atopic dermatitis (AD) via treatment with leucine-rich glioma inactivated 3 (LGI3) peptide. Male NC/Nga mice (7 weeks, 20 g) were randomly allocated into three groups (control, AD, and LGI3 group)
Ui Seok Kim, Jin Woo Park, Eon Sub Park, Joon Seok Bang, Tae Woo Jung, Dong-Seok Kim, A. M. Abd El-Aty, Jong Hyuk Lee, Ji Hoon Jeong   +8 more
doaj   +1 more source

Dupilumab Significantly Reduces Symptoms of Prurigo Nodularis and Depression: A Case Series

Acta Dermato-Venereologica, 2022
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Louise Lönndahl, Maria Lundqvist, Maria Bradley, Emma K. Johansson   +3 more
doaj   +1 more source