Results 51 to 60 of about 9,136 (192)

3D-Organotypic Cultures to Unravel Molecular and Cellular Abnormalities in Atopic Dermatitis and Ichthyosis Vulgaris

Cells, 2019
Atopic dermatitis (AD) is characterized by dry and itchy skin evolving into disseminated skin lesions. AD is believed to result from a primary acquired or a genetically-induced epidermal barrier defect leading to immune hyper-responsiveness.
Géraldine Leman, Verena Moosbrugger-Martinz, Stefan Blunder, Petra Pavel, Sandrine Dubrac   +4 more
doaj   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

A de novo variant in the ASPRV1 gene in a dog with ichthyosis. [PDF]

PLoS Genetics, 2017
Ichthyoses are a heterogeneous group of inherited cornification disorders characterized by generalized dry skin, scaling and/or hyperkeratosis. Ichthyosis vulgaris is the most common form of ichthyosis in humans and caused by genetic variants in the FLG ...
Anina Bauer, Dominik P Waluk, Arnaud Galichet, Katrin Timm, Vidhya Jagannathan, Beyza S Sayar, Dominique J Wiener, Elisabeth Dietschi, Eliane J Müller, Petra Roosje, Monika M Welle, Tosso Leeb   +11 more
doaj   +1 more source

Filaggrin Null Alleles Are Not Associated with Psoriasis [PDF]

Journal of Investigative Dermatology, 2007
Psoriasis is a common skin disease with an etiology consistent with a multifactorial trait. Several psoriasis susceptibility loci are known, a number of which are also implicated in a predisposition to atopic dermatitis (AD), including the epidermal differentiation complex on chromosome 1q21. It has recently been shown in several replicate studies that
Zhao, Y, Terron-Kwiatkowski, A, Liao, H, Lee, SP, Allen, MH, Hull, PR, Campbell, LE, Trembath, RC, Capon, F, Griffiths, CEM, Burden, D, McManus, R, Hughes, R, Kirby, B, Rogers, SF, Fitzgerald, O, Kane, D, Barker, JNWN, Palmer, CNA, Irvine, AD, McLean, WHI   +20 more
openaire   +4 more sources

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Expression of Filaggrin and its Degradation Products in Human Skin Following Erythemal Doses of Ultraviolet B Irradiation

Acta Dermato-Venereologica, 2017
Epidermal filaggrin level is affected by ultraviolet B irradiation in animal and experimental models. This study examined the effect of ultraviolet B irradiation on epidermal filaggrin and natural moisturizing factors in vivo in healthy adults (n = 22 ...
Stine Simonsen, Jacob P. Thyssen, Steffen Heegaard, Sanja Kezic, Lone Skov   +4 more
doaj   +1 more source

Filaggrin sequencing and bioinformatics tools

Archives of Dermatological Research, 2019
Atopic dermatitis (AD) is a common illness that most commonly originates in childhood, but can be seen in all ages. Filaggrin (FLG) loss of function variants have been associated with the onset and severity of atopic dermatitis and are the most common genetic association with AD. Previous studies have shown variability in the frequency of FLG variants.
David J. Margolis, Nandita Mitra, Bradley Wubbenhorst, Katherine L. Nathanson   +3 more
openaire   +3 more sources

Shotgun Metagenomics Reveals Skin Microbiome Composition and Function in Infant Atopic Disease

Allergy, EarlyView.
Deep shotgun metagenomics profiled > 1000 infant skin swabs in the VITALITY cohort. Distinct skin microbiome signatures separated AD alone from AD with allergic co‐occurrence. Early Staphylococcus enrichment preceded later AD with allergic co‐occurrence. FLG mutations and strain‐level analyses revealed host and microbial features linked to AD.
Zeyang Shen, Jana K. Eckert, Richard Saffery, Katrina J. Allen, Audrey Walsh, VITALITY team, Kirsten Perrett, Katrina J. Allen, Justin Brown, Natalie Carvalho, Nigel Curtis, Kim Daziel, Shyamali Dharmage, Ronda Greaves, Lyle Gurrin, Li Huang, Jennifer Koplin, Katherine Lee, Georgia Paxton, Rachel Peters, Anne‐Louise Ponsonby, Peter Sayre, Mimi Tang, Peter Vuillermin, Melissa Wake, Angela Young, Deborah Anderson, Christine Axelrad, Anna Bourke, Kirsty Bowes, Tim Brettig, Natasha Burgess, Beatriz Camesella‐Perez, Xueyuan Che, Daniela Ciciulla, Jac Cushnahan, Helen Czech, Thanh Dang, Kathryn Dawes, Jana Eckert, Hannah Elborough, Michael Field, Charlie Fink, Sarah Fowler, Grace Gell, Rebecca Gray, Emi Habgood, Richard Hall, Phoebe Harris, Erin Hill, Kensuke Hoashi, Hannah Ilhan, Narelle Jenkins, Andrew Knox, Clare Morrison, Melanie Neeland, Jenn Ness, Wendy Norton, Sasha Odoi, Mary Panjari, Kayla Parker, Ahelee Rahman, Ashleigh Rak, Maisie Ralphsmith, Natalie Schreurs, Carrie Service, Victoria Soriano, Judith Spotswood, Mark Taranto, Leone Thiele, Kate Wall, Audrey Walsh, Angela Walsh, Anita Wise, Andrew Davidson, Arul Earnest, Lara Ford, Andrew Kemp, Sam Mehr, Tibor Schuster, Dean Tey, Diana Zannino, Donna Legge, Jason Bell, Joanne Cheah, Kay Hynes, Kee Lim, Emily Porrello, Annette Powell, Pedro Ramos, Anushka Karunanayake, Izabelle Mezzetti, Kayla Parker, Ronita Singh, Harriet Edmund, Bridie Byrne, Tom Keeble, Cuby Martis, Belle Ngien, Penny Glenn, Andrew Kaynes, Clay Deming, Qiong Chen, Karen Laky, Jenny Min Li, Lindsay Chatman, NISC Comparative Sequencing Program, Beatrice B. Barnabas, Sean Black, Gerard G. Bouffard, Shelise Y. Brooks, Juyun Crawford, Holly Marfani, Lyudmila Dekhtyar, Joel Han, Shi‐Ling Ho, Richelle Legaspi, Quino L. Maduro, Catherine A. Masiello, Jennifer C. McDowell, Casandra Montemayor, James C. Mullikin, Morgan Park, Nancy L. Riebow, Karen Schandler, Brian Schmidt, Christina Sison, Sirintorn Stantripop, James W. Thomas, Pamela J. Thomas, Meghana Vemulapalli, Alice C. Young, Heidi H. Kong, Kirsten P. Perrett, Julia A. Segre, Pamela A. Frischmeyer‐Guerrerio   +135 more
wiley   +1 more source

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents

Scientific Reports, 2017
Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to its pathophysiology.
Leonie Wallmeyer, Kristina Dietert, Michaela Sochorová, Achim D. Gruber, Burkhard Kleuser, Kateřina Vávrová, Sarah Hedtrich   +6 more
doaj   +1 more source

Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study. [PDF]

PLoS ONE, 2012
BackgroundFilaggrin null mutations result in impaired skin barrier functions, increase the risk of early onset atopic dermatitis and lead to a more severe and chronic disease.
Charlotte Giwercman Carson, Morten Arendt Rasmussen, Jacob P Thyssen, Torkil Menné, Hans Bisgaard   +4 more
doaj   +1 more source